1989
ENDOTHELIAL CELL ACTIVATION AND HIGH INTERLEUKIN-1 SECRETION IN THE PATHOGENESIS OF ACUTE KAWASAKI DISEASE
Leung D, Kurt-Jones E, Newburger J, Cotran R, Burns J, Pober J. ENDOTHELIAL CELL ACTIVATION AND HIGH INTERLEUKIN-1 SECRETION IN THE PATHOGENESIS OF ACUTE KAWASAKI DISEASE. The Lancet 1989, 334: 1298-1302. PMID: 2480498, DOI: 10.1016/s0140-6736(89)91910-7.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, SurfaceCell AdhesionCell Adhesion MoleculesChild, PreschoolEndothelium, VascularE-SelectinFemaleGamma-GlobulinsHLA-DQ AntigensHumansImmunization, PassiveIntercellular Adhesion Molecule-1Interleukin-1MaleMembrane GlycoproteinsMucocutaneous Lymph Node SyndromeReceptors, ImmunologicSkinConceptsEndothelial cell activationCoronary artery abnormalitiesCell activationInterleukin-1Gammaglobulin treatmentArtery abnormalitiesKawasaki diseaseAcute Kawasaki disease patientsPeripheral blood mononuclear cellsEndothelial cellsCytotoxic antibody activityIntravenous gammaglobulin treatmentKawasaki disease patientsAcute Kawasaki diseaseEndothelial cell antigensBlood mononuclear cellsInterleukin-1 secretionTumor necrosis factorIL-1 secretionEndothelial cell expressionSkin biopsy samplesMeans of immunoperoxidaseMucocutaneous symptomsPersistent feverClinical symptoms
1988
Endothelial activation during interleukin 2 immunotherapy. A possible mechanism for the vascular leak syndrome.
Cotran RS, Pober JS, Gimbrone MA, Springer TA, Wiebke EA, Gaspari AA, Rosenberg SA, Lotze MT. Endothelial activation during interleukin 2 immunotherapy. A possible mechanism for the vascular leak syndrome. The Journal Of Immunology 1988, 140: 1883-8. PMID: 3279124, DOI: 10.4049/jimmunol.140.6.1883.Peer-Reviewed Original ResearchConceptsIntercellular adhesion molecule-1Adhesion molecule-1Endothelial cell activationVascular leak syndromeEndothelial leukocyte adhesion molecule-1Leak syndromeMolecule-1IL-2Cell activationCultured endothelial cellsEndothelial expressionImmune responseEndothelial leukocyte adhesion molecule-1 expressionLeu-10Cell-mediated immune responsesAdhesion molecule-1 expressionEndothelial cellsDifferent activation antigensInterleukin-2 immunotherapyPost-treatment skinIL-2 therapyPostcapillary venular endotheliumMolecule-1 expressionIL-2 actsDays of treatmentEffects of recombinant gamma-interferon on HLA-DR and DQ expression by skin cells in short-term organ culture.
Messadi DV, Pober JS, Murphy GF. Effects of recombinant gamma-interferon on HLA-DR and DQ expression by skin cells in short-term organ culture. Laboratory Investigation 1988, 58: 61-7. PMID: 3121914.Peer-Reviewed Original ResearchConceptsShort-term organ cultureHLA-DRLangerhans cellsOrgan cultureT6-positive Langerhans cellsClass II major histocompatibility antigensImmune interferonClass II major histocompatibility moleculesEpidermal dendritic cellsCutaneous immune responsesDendritic cell populationsHLA-DR expressionSkin microvascular endothelial cellsMajor histocompatibility antigensMicrovascular endothelial cellsSkin cellsNewborn human foreskinMajor histocompatibility moleculesDendritic cellsInflammatory mediatorsDQ expressionHLA-DQOrgan culture systemHistocompatibility antigensImmune response
1984
Immune interferon activates multiple class II major histocompatibility complex genes and the associated invariant chain gene in human endothelial cells and dermal fibroblasts.
Collins T, Korman AJ, Wake CT, Boss JM, Kappes DJ, Fiers W, Ault KA, Gimbrone MA, Strominger JL, Pober JS. Immune interferon activates multiple class II major histocompatibility complex genes and the associated invariant chain gene in human endothelial cells and dermal fibroblasts. Proceedings Of The National Academy Of Sciences Of The United States Of America 1984, 81: 4917-4921. PMID: 6431411, PMCID: PMC391603, DOI: 10.1073/pnas.81.15.4917.Peer-Reviewed Original ResearchConceptsAntigen expressionIFN-gammaSurface expressionClass II major histocompatibility complex antigensClass II antigen expressionImmune interferonClass II MHC antigensEndothelial cellsMajor histocompatibility complex antigensImmune accessory functionHLA-DR antigensClass II antigensHistocompatibility complex antigensVascular endothelial cellsHLA-DCDermal fibroblastsHuman endothelial cellsHLA-DRMHC antigensII antigensComplex antigensB antigensDe novo appearanceClass IIStromal cells