1986
Recombinant tumor necrosis factor and immune interferon act singly and in combination to reorganize human vascular endothelial cell monolayers.
Stolpen AH, Guinan EC, Fiers W, Pober JS. Recombinant tumor necrosis factor and immune interferon act singly and in combination to reorganize human vascular endothelial cell monolayers. American Journal Of Pathology 1986, 123: 16-24. PMID: 2421578, PMCID: PMC1888144.Peer-Reviewed Original ResearchConceptsRecombinant tumor necrosis factorHuman endothelial cellsTumor necrosis factorNecrosis factorMorphologic changesRecombinant immune interferonSimilar morphologic changesUnique morphologic changesVascular endothelial cell monolayersVascular responsesEndothelial cell monolayersPrimary human endothelial cellsEndothelial cell morphologyVascular liningConfluent primary culturesEpithelioid organizationImmune interferonEndothelial cellsSpinelike processesPrimary cultures
1982
Expression of Ia-like antigens by human vascular endothelial cells is inducible in vitro: demonstration by monoclonal antibody binding and immunoprecipitation.
Pober JS, Gimbrone MA. Expression of Ia-like antigens by human vascular endothelial cells is inducible in vitro: demonstration by monoclonal antibody binding and immunoprecipitation. Proceedings Of The National Academy Of Sciences Of The United States Of America 1982, 79: 6641-6645. PMID: 6815654, PMCID: PMC347184, DOI: 10.1073/pnas.79.21.6641.Peer-Reviewed Original ResearchConceptsHuman vascular endothelial cellsCell shape changesVascular endothelial cellsEndothelial cellsMembrane proteinsCell divisionRadioiodinated membrane proteinsHuman endothelial cellsStandard culture conditionsIntact cellsCultured human endothelial cellsBiochemical demonstrationImmunoprecipitationCulture conditionsConfluent culturesExpressionMonoclonal antibody bindingCellsPrimary culturesShape changesMonoclonal antibodiesLectin phytohemagglutininProteinRegulationImportant implications