2001
Tumor Necrosis Factor Alpha Increases Human Cerebral Endothelial Cell Gb3 and Sensitivity to Shiga Toxin
Eisenhauer P, Chaturvedi P, Fine R, Ritchie A, Pober J, Cleary T, Newburg D. Tumor Necrosis Factor Alpha Increases Human Cerebral Endothelial Cell Gb3 and Sensitivity to Shiga Toxin. Infection And Immunity 2001, 69: 1889-1894. PMID: 11179369, PMCID: PMC98098, DOI: 10.1128/iai.69.3.1889-1894.2001.Peer-Reviewed Original ResearchConceptsHemolytic uremic syndromeShiga toxinMicrovascular brain endothelial cellsCentral nervous system pathologyTumor necrosis factor alphaEndothelial cellsShiga toxin toxicityNervous system pathologyBrain endothelial cellsNecrosis factor alphaTNF-alpha treatmentUmbilical vein endothelial cellsCNS involvementVein endothelial cellsUremic syndromeIntestinal infectionsShiga Toxin BindingFactor alphaEnterohemorrhagic Escherichia coliSystem pathologyFunctional receptorsNormal fatty acidsToxin bindingFatty acidsToxin
1997
Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: Implications for CD40–CD40 ligand signaling in atherosclerosis
Mach F, Schönbeck U, Sukhova G, Bourcier T, Bonnefoy J, Pober J, Libby P. Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: Implications for CD40–CD40 ligand signaling in atherosclerosis. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 1931-1936. PMID: 9050882, PMCID: PMC20020, DOI: 10.1073/pnas.94.5.1931.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, Differentiation, T-LymphocyteArteriosclerosisBlotting, WesternB-LymphocytesCD40 AntigensCD40 LigandCells, CulturedEndothelium, VascularFlow CytometryGene Expression RegulationHumansImmunohistochemistryInterferon-gammaInterleukin-1MacrophagesMembrane GlycoproteinsMuscle, Smooth, VascularRNA, MessengerSignal TransductionTumor Necrosis Factor-alphaConceptsHuman vascular endothelial cellsSmooth muscle cellsVascular endothelial cellsHuman atherosclerotic lesionsHuman macrophagesCell typesEndothelial cellsMuscle cellsHuman vascular smooth muscle cellsVascular smooth muscle cellsDe novo synthesisCD40 ligandBroad functionsAtherosclerotic lesionsCD40 SignalingTumor necrosis factor alphaFunctional CD40 ligandInvolvement of inflammationCultured human vascular endothelial cellsCD40-CD40 ligandNovo synthesisNecrosis factor alphaParacrine activationNormal arterial tissueNovel source