1997
Pig but not human interferon-γ initiates human cell-mediated rejection of pig tissue in vivo
Sultan P, Murray A, McNiff J, Lorber M, Askenase P, Bothwell A, Pober J. Pig but not human interferon-γ initiates human cell-mediated rejection of pig tissue in vivo. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 8767-8772. PMID: 9238052, PMCID: PMC23121, DOI: 10.1073/pnas.94.16.8767.Peer-Reviewed Original ResearchConceptsHuman peripheral blood mononuclear cellsPeripheral blood mononuclear cellsPig skin graftsCell-mediated rejectionBlood mononuclear cellsIFN-gammaMononuclear cellsSkin graftsDermal microvesselsMajor histocompatibility complex (MHC) molecule expressionT cell-mediated rejectionPerivascular mononuclear cell infiltratesClass II major histocompatibility complex moleculesMononuclear cell infiltrateMajor histocompatibility complex moleculesTumor necrosis factorEvidence of injuryHistocompatibility complex moleculesPig endothelial cellsCell infiltrateIntradermal injectionMolecule expressionSparse infiltrateIntraperitoneal inoculationMouse microvessels
1991
Expression of endothelial-leukocyte adhesion molecule-1 in elicited late phase allergic reactions.
Leung DY, Pober JS, Cotran RS. Expression of endothelial-leukocyte adhesion molecule-1 in elicited late phase allergic reactions. Journal Of Clinical Investigation 1991, 87: 1805-1809. PMID: 1708785, PMCID: PMC295299, DOI: 10.1172/jci115201.Peer-Reviewed Original ResearchConceptsLate-phase reactionInflammatory cellsAllergic reactionsEC activationLate-phase allergic reactionsEndothelial leukocyte adhesion molecule-1Adhesion moleculesIntradermal allergen injectionSequential skin biopsiesInflammatory cell infiltrateNeutrophil adhesion moleculesEndothelial leukocyte adhesion moleculeAllergic skin reactionsELAM-1 expressionOrgan cultureAdhesion molecule-1Skin organ cultureAtopic patientsCell infiltrateEndothelial activationAllergen injectionRespiratory allergySkin reactionsTNF-alphaIntradermal injection