2022
Wanted: An endothelial cell targeting atlas for nanotherapeutic delivery in allograft organs
Liburd ST, Shi AA, Pober JS, Tietjen GT. Wanted: An endothelial cell targeting atlas for nanotherapeutic delivery in allograft organs. American Journal Of Transplantation 2022, 22: 1754-1759. PMID: 35373446, PMCID: PMC9651180, DOI: 10.1111/ajt.17050.Peer-Reviewed Original ResearchConceptsNormothermic machine perfusionEndothelial cellsGraft vasculaturePoor outcomePreservation injuryMachine perfusionProfound shortageOrgan assessmentTransplant therapeuticsDonor comorbiditiesAllograft organClinical useOrgansAttractive targetNanotherapeutic deliveryTherapeutic vehiclesCellsTherapeutic deliveryDeliveryComorbiditiesTransplantGraftInjuryPerfusionVasculature
2014
Eculizumab Therapy for Chronic Antibody-Mediated Injury in Kidney Transplantation: An Interim Assessment.
Kulkarni S, Nancy K, Formica R, Moeckel G, Pober J. Eculizumab Therapy for Chronic Antibody-Mediated Injury in Kidney Transplantation: An Interim Assessment. Transplantation 2014, 98: 79. DOI: 10.1097/00007890-201407151-00247.Peer-Reviewed Original Research
2008
Chapter 2 Physiology and Pathobiology of Microvascular Endothelium
Pober J. Chapter 2 Physiology and Pathobiology of Microvascular Endothelium. 2008, 37-55. DOI: 10.1016/b978-0-12-374530-9.00002-4.Peer-Reviewed Original ResearchMicrovascular ECsVascular ECsRegulation of inflammationType II activationEarly activation eventsPlastic cell typeCell typesEndothelial dysfunctionInflammatory processAdaptive immunityChapter 2 PhysiologyBlood flowMicrovascular endotheliumVascular endotheliumBlood fluidityInflammation processEpithelial-like cellsHost defenseInflammationEntire circulatory systemCirculatory systemDysfunctionInjuryEndotheliumBlood
2006
Endothelial Cell Dysfunction, Injury and Death
Pober JS, Min W. Endothelial Cell Dysfunction, Injury and Death. Handbook Of Experimental Pharmacology 2006, 176/II: 135-156. PMID: 16999227, DOI: 10.1007/3-540-36028-x_5.Peer-Reviewed Original ResearchConceptsTumor necrosis factorCytolytic T lymphocytesEC injuryEndothelial cellsReactive oxygen speciesEndothelial cell dysfunctionMacrophage-derived cytokinesVascular endothelial cellsEndothelial dysfunctionNecrosis factorCell dysfunctionT lymphocytesInjuryCommon mediatorInflammationDysfunctionDeathOxygen speciesCytokinesLymphocytesNeutrophilsDifferent agentsBiochemical pathways
2000
IL-11 Activates Human Endothelial Cells to Resist Immune-Mediated Injury
Mahboubi K, Biedermann B, Carroll J, Pober J. IL-11 Activates Human Endothelial Cells to Resist Immune-Mediated Injury. The Journal Of Immunology 2000, 164: 3837-3846. PMID: 10725745, DOI: 10.4049/jimmunol.164.7.3837.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, CDCells, CulturedComplement System ProteinsCytokine Receptor gp130Cytotoxicity, ImmunologicDNA-Binding ProteinsDose-Response Relationship, ImmunologicEndothelium, VascularEnzyme ActivationHumansImmunity, InnateInflammation MediatorsInterleukin-11Interleukin-11 Receptor alpha SubunitMembrane GlycoproteinsMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Mitogen-Activated Protein KinasesNF-kappa BPhosphorylationReceptors, InterleukinReceptors, Interleukin-11Signal TransductionSTAT1 Transcription FactorSTAT3 Transcription FactorT-Lymphocytes, CytotoxicTrans-ActivatorsTyrosineUmbilical VeinsConceptsIL-11Mitogen-activated protein kinaseP44 mitogen-activated protein kinaseImmune-Mediated InjuryCytolytic T lymphocytesNF-kappaB activationGp130-signaling cytokinesInflammatory injuryHuman endothelial cellsIL-11 receptorProinflammatory responseMolecule expressionT lymphocytesICAM-1Maximal responseE-selectinMHC AbsVivo modelNF-kappaBEndothelial cellsTyrosine phosphorylationPhospho-STAT3Cultured HUVECsInjuryKinase 1 inhibitor
1997
Blockade of CD2-LFA-3 interactions protects human skin allografts in immunodeficient mouse/human chimeras
Sultan P, Schechner J, McNiff J, Hochman P, Hughes C, Lorber M, Askenase P, Pober J. Blockade of CD2-LFA-3 interactions protects human skin allografts in immunodeficient mouse/human chimeras. Nature Biotechnology 1997, 15: 759-762. PMID: 9255790, DOI: 10.1038/nbt0897-759.Peer-Reviewed Original ResearchConceptsSkin graftsLFA-3Human T-cell infiltrationIsotype-matched control antibodyT cell infiltrationSkin graft rejectionHuman skin graftsHuman skin allograftsCD2-LFA-3 interactionHuman LFA-3Microvascular injuryGraft rejectionLeukocyte infiltrationSkin allograftsImmune modulatorsControl antibodyInjury modelImmunodeficient miceImmune reactionsMouse/human chimeraMurine mAbsCD2 interactionPrincipal ligandGraftInjury
1992
Recent Insights into the Mechanisms of Vascular Injury
Cotran R, Pober J. Recent Insights into the Mechanisms of Vascular Injury. 1992, 183-189. DOI: 10.1007/978-1-4899-0721-9_11.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsVascular injuryPathogenesis of vasculitisForms of vasculitisSubsequent complement activationCapillary basement membraneBlood vessel wallCytoplasmic antibodiesInflammatory vasculitisWegener's granulomatosisGoodpasture's syndromePathogenetic mechanismsImmune complexesSystemic necrotizingVasculitisComplement activationInjuryEndothelial cellsHeterogeneous groupVessel wallTransplantation reactionsGranulomatosisBasement membraneInflammationSyndromePossible role
1991
Immunologic Basis of Cardiovascular Disease: An overview
Pober J. Immunologic Basis of Cardiovascular Disease: An overview. Clinical Cardiology 1991, 14: 1-2. DOI: 10.1002/clc.4960140601.Peer-Reviewed Original Research
1990
Cytokine-endothelial interactions in inflammation, immunity, and vascular injury.
Cotran RS, Pober JS. Cytokine-endothelial interactions in inflammation, immunity, and vascular injury. Journal Of The American Society Of Nephrology 1990, 1: 225-35. PMID: 2104268, DOI: 10.1681/asn.v13225.Peer-Reviewed Original ResearchConceptsVascular injuryTumor necrosis factorEffects of cytokinesEndothelial adhesion moleculesLeukocyte-endothelial adhesionCytokine-induced activationSuch pathological processesSeptic shockNecrosis factorImmune responseInterleukin-1Shwartzman reactionAdhesion moleculesPathological processesCytokinesInjuryStructural alterationsBiological characteristicsPossible contributionVasculitisInflammationEndotheliumHypersensitivityImmunityImportant role
1989
Effects of cytokines on vascular endothelium: Their role in vascular and immune injury
Cotran R, Pober J. Effects of cytokines on vascular endothelium: Their role in vascular and immune injury. Kidney International 1989, 35: 969-975. PMID: 2651773, DOI: 10.1038/ki.1989.80.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsEffects of cytokinesEndothelial cellsCytokine-induced effectsRenal injuryEndothelial functionImmune injuryEndothelial activationVascular toneRenal endotheliumImmune functionCell injuryVascular endotheliumCritical homeostatic functionsEndothelium participatesClinical settingHomeostatic functionsTranscapillary permeabilityCytokinesInjurySpecific alterationsInflammationControl of proliferationHematopoietic cellsEndotheliumRecent studiesEndothelial Activation and Inflammation
Cotran R, Pober J. Endothelial Activation and Inflammation. 1989, 747-753. DOI: 10.1007/978-3-642-83755-5_101.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
1988
Warner-Lambert/Parke-Davis award lecture. Cytokine-mediated activation of vascular endothelium. Physiology and pathology.
Pober JS. Warner-Lambert/Parke-Davis award lecture. Cytokine-mediated activation of vascular endothelium. Physiology and pathology. American Journal Of Pathology 1988, 133: 426-33. PMID: 2462353, PMCID: PMC1880803.Peer-Reviewed Original ResearchConceptsEndothelial cell activationCell activationMolecular biologic techniquesEndothelial cell functionClinical studiesMorphologic definitionVascular endotheliumBiologic techniquesPatient-based clinical researchClinical researchBiologic definitionVivo studiesHarmful sequencesCell functionDysfunctionInjuryActivationRecent studies