2021
Mitochondrial fission in allograft endothelial cells: A novel actionable target
Mullan CW, Pober JS. Mitochondrial fission in allograft endothelial cells: A novel actionable target. American Journal Of Transplantation 2021, 22: 337-338. PMID: 34865296, DOI: 10.1111/ajt.16911.Commentaries, Editorials and Letters
2011
Vascular Endothelial Cells as Immunological Targets in Atheroscleroisis
Fogal B, Pober J. Vascular Endothelial Cells as Immunological Targets in Atheroscleroisis. 2011, 87-114. DOI: 10.1007/978-3-7091-0338-8_6.Peer-Reviewed Original ResearchSequelae of atherosclerosisProgression of atherosclerosisChronic inflammatory responseVessel wall toneProcess of atherogenesisImmune system cellsVascular endothelial cellsEndothelial dysfunctionAtherosclerotic processAltered endotheliumImmunological targetsInflammatory responseImpaired endotheliumWall toneImmune responseAdaptive immunityVascular permeabilityAtherosclerotic plaquesVascular endotheliumBlood fluidityImmune systemSystem cellsAtherosclerosisArterial wallEndothelial cells
2000
Large-Scale Culture and Selective Maturation of Human Langerhans Cells from Granulocyte Colony-Stimulating Factor-Mobilized CD34+ Progenitors
Gatti E, Velleca M, Biedermann B, Ma W, Unternaehrer J, Ebersold M, Medzhitov R, Pober J, Mellman I. Large-Scale Culture and Selective Maturation of Human Langerhans Cells from Granulocyte Colony-Stimulating Factor-Mobilized CD34+ Progenitors. The Journal Of Immunology 2000, 164: 3600-3607. PMID: 10725716, DOI: 10.4049/jimmunol.164.7.3600.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntigens, CD1Antigens, CD34Antigens, Differentiation, T-LymphocyteAntigens, NeoplasmCD40 LigandCell CountCell Culture TechniquesCell DifferentiationDendritic CellsGranulocyte Colony-Stimulating FactorHematopoietic Stem Cell TransplantationHumansImmunophenotypingLangerhans CellsLeukapheresisLigandsLipopolysaccharidesMembrane GlycoproteinsStem CellsTumor Necrosis Factor-alphaConceptsDendritic cellsLangerhans cellsT cell stimulationG-CSF-mobilized patientsManipulation of DCsImmature dendritic cellsIL-12 productionPrimary immune responseHuman Langerhans cellsCell stimulationDifferent proinflammatory stimuliToll family receptorsDC preparationsMaturation stimuliTNF-alphaCD40 ligandMHC productsImmune responseBirbeck granulesProinflammatory stimuliCytokine removalFamily receptorsAg processingDC typesHomogenous population
1998
Transplantation Models in Human/Mouse Chimeras
Tellides G, Kirkiles N, Tereb D, Schechner J, Wilson J, Lorber M, Pober J. Transplantation Models in Human/Mouse Chimeras. 1998, 615-626. DOI: 10.1007/978-3-642-72140-3_63.Peer-Reviewed Original ResearchPeripheral blood mononuclear cellsSevere combined immunodeficiencyHuman/mouse chimerasTransplantation modelImmune responseB lymphocytesNatural killer cell activityMouse chimerasHuman peripheral blood mononuclear cellsEndothelial cellsKiller cell activityHuman peripheral blood leukocytesCellular immune responsesBlood mononuclear cellsHuman immune responsePeripheral blood leukocytesHuman mononuclear leukocytesPig endothelial cellsHuman allogeneicPig graftsArtery graftAdoptive transferNK cellsMononuclear cellsHost mice
1990
Cytokine-endothelial interactions in inflammation, immunity, and vascular injury.
Cotran RS, Pober JS. Cytokine-endothelial interactions in inflammation, immunity, and vascular injury. Journal Of The American Society Of Nephrology 1990, 1: 225-35. PMID: 2104268, DOI: 10.1681/asn.v13225.Peer-Reviewed Original ResearchConceptsVascular injuryTumor necrosis factorEffects of cytokinesEndothelial adhesion moleculesLeukocyte-endothelial adhesionCytokine-induced activationSuch pathological processesSeptic shockNecrosis factorImmune responseInterleukin-1Shwartzman reactionAdhesion moleculesPathological processesCytokinesInjuryStructural alterationsBiological characteristicsPossible contributionVasculitisInflammationEndotheliumHypersensitivityImmunityImportant role
1988
Endothelial activation during interleukin 2 immunotherapy. A possible mechanism for the vascular leak syndrome.
Cotran RS, Pober JS, Gimbrone MA, Springer TA, Wiebke EA, Gaspari AA, Rosenberg SA, Lotze MT. Endothelial activation during interleukin 2 immunotherapy. A possible mechanism for the vascular leak syndrome. The Journal Of Immunology 1988, 140: 1883-8. PMID: 3279124, DOI: 10.4049/jimmunol.140.6.1883.Peer-Reviewed Original ResearchConceptsIntercellular adhesion molecule-1Adhesion molecule-1Endothelial cell activationVascular leak syndromeEndothelial leukocyte adhesion molecule-1Leak syndromeMolecule-1IL-2Cell activationCultured endothelial cellsEndothelial expressionImmune responseEndothelial leukocyte adhesion molecule-1 expressionLeu-10Cell-mediated immune responsesAdhesion molecule-1 expressionEndothelial cellsDifferent activation antigensInterleukin-2 immunotherapyPost-treatment skinIL-2 therapyPostcapillary venular endotheliumMolecule-1 expressionIL-2 actsDays of treatmentEffects of recombinant gamma-interferon on HLA-DR and DQ expression by skin cells in short-term organ culture.
Messadi DV, Pober JS, Murphy GF. Effects of recombinant gamma-interferon on HLA-DR and DQ expression by skin cells in short-term organ culture. Laboratory Investigation 1988, 58: 61-7. PMID: 3121914.Peer-Reviewed Original ResearchConceptsShort-term organ cultureHLA-DRLangerhans cellsOrgan cultureT6-positive Langerhans cellsClass II major histocompatibility antigensImmune interferonClass II major histocompatibility moleculesEpidermal dendritic cellsCutaneous immune responsesDendritic cell populationsHLA-DR expressionSkin microvascular endothelial cellsMajor histocompatibility antigensMicrovascular endothelial cellsSkin cellsNewborn human foreskinMajor histocompatibility moleculesDendritic cellsInflammatory mediatorsDQ expressionHLA-DQOrgan culture systemHistocompatibility antigensImmune response
1983
Ia expression by vascular endothelium is inducible by activated T cells and by human gamma interferon.
Pober JS, Gimbrone MA, Cotran RS, Reiss CS, Burakoff SJ, Fiers W, Ault KA. Ia expression by vascular endothelium is inducible by activated T cells and by human gamma interferon. Journal Of Experimental Medicine 1983, 157: 1339-1353. PMID: 6403654, PMCID: PMC2186979, DOI: 10.1084/jem.157.4.1339.Peer-Reviewed Original ResearchConceptsAllogeneic T cellsT cellsIa antigensEndothelial cellsPeripheral blood mononuclear cellsBlood mononuclear cellsCultured human umbilical vein endothelial cellsExpression of IaActivated T cellsHuman umbilical vein endothelial cellsUmbilical vein endothelial cellsAllograft rejectionVein endothelial cellsGamma interferon geneFluorescence flow cytometryHuman gamma interferonMononuclear cellsImmune responseGamma interferonVascular endotheliumIa expressionFlow cytometryImmune interferonMonoclonal antibodiesAntigen