1996
Endothelial cells augment the expression of CD40 ligand on newly activated human CD4+ T cells through a CD2/LFA‐3 signaling pathway
Karmann K, Hughes C, Fanslow W, Pober J. Endothelial cells augment the expression of CD40 ligand on newly activated human CD4+ T cells through a CD2/LFA‐3 signaling pathway. European Journal Of Immunology 1996, 26: 610-617. PMID: 8605928, DOI: 10.1002/eji.1830260316.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntigens, Differentiation, T-LymphocyteB-LymphocytesCD2 AntigensCD40 LigandCD4-Positive T-LymphocytesCD58 AntigensCell AdhesionCell CommunicationCells, CulturedEndothelium, VascularHumansInterleukin-2LigandsLymphocyte ActivationMembrane GlycoproteinsPhytohemagglutininsSignal TransductionUp-RegulationConceptsCD40 ligand expressionExogenous IL-2T cellsIL-2Ligand expressionCD2/LFACD40 ligandHuman peripheral blood CD4Peripheral blood adherent cellsHelper T cell subsetsPeripheral blood T cellsPeripheral blood CD4T cell subsetsCo-stimulatory moleculesBlood T cellsHelper T cellsIL-2 receptorCo-stimulatory signalsIL-2 secretionInterleukin-2 secretionBlood CD4Endothelial effectsCell subsetsHuman CD4B cells
1990
The potential roles of vascular endothelium in immune reactions
Pober J, Doukas J, Hughes C, Savage C, Munro J, Cotran R. The potential roles of vascular endothelium in immune reactions. Human Immunology 1990, 28: 258-262. PMID: 2190954, DOI: 10.1016/0198-8859(90)90027-m.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCell-mediated immune reactionsT cellsImmune reactionsEndothelial cellsFunctional T cell activationClass II major histocompatibility complex moleculesImmune accessory functionAntigen-specific CD4Helper T cellsAntigen presenting cellsDevelopment of inflammationMajor histocompatibility complex moleculesBlood-derived leukocytesImmune accessory cellsCell typesT cell activationHistocompatibility complex moleculesVascular endothelial cellsSpecific CD4Inflammatory infiltrateVascular responsesPresenting cellsForeign antigensVascular endotheliumCostimulatory signals
1989
Functions of vascular wall cells related to development of transplantation-associated coronary arteriosclerosis.
Libby P, Salomon RN, Payne DD, Schoen FJ, Pober JS. Functions of vascular wall cells related to development of transplantation-associated coronary arteriosclerosis. Transplantation Proceedings 1989, 21: 3677-84. PMID: 2669279.Peer-Reviewed Original ResearchConceptsArterial diseaseT cellsVascular cellsChronic immune reactionsTransplantation-associated arteriosclerosisTypical acute rejectionDelayed-type hypersensitivityHelper T cellsWall cellsClass II HLACytolytic T cellsVascular wall cellsClass I HLAVessel wall cellsUnderstanding of atherogenesisAcute rejectionGraft arteryCoronary arteriosclerosisCoronary atherosclerosisBasic pathobiologyCellular immunityImmune activationSelective therapeutic strategiesCoronary circulationAccelerated disease
1987
Lymphocyte Interactions with Endothelial Cells
Pober J. Lymphocyte Interactions with Endothelial Cells. Gwumc Department Of Biochemistry And Molecular Biology Annual Spring Symposia 1987, 211-217. DOI: 10.1007/978-1-4684-5296-9_25.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPeripheral blood mononuclear cellsClass II moleculesHuman endothelial cellsPBMC proliferationSmooth muscle cellsT cellsEndothelial cellsInterleukin-1Cultures of PBMCHEC culturesAllogeneic peripheral blood mononuclear cellsResponse of PBMCClass II major histocompatibility complex antigensMuscle cellsCytolytic T lymphocyte clonesMajor histocompatibility complex antigensAllogeneic PBMC proliferationExogenous interleukin 1Allogeneic T cellsVascular smooth muscle cellsBlood mononuclear cellsDermal fibroblastsHelper T cellsHistocompatibility complex antigensT lymphocyte clones
1985
Human dermal fibroblasts present tetanus toxoid antigen to antigen-specific T cell clones.
Umetsu DT, Pober JS, Jabara HH, Fiers W, Yunis EJ, Burakoff SJ, Reiss CS, Geha RS. Human dermal fibroblasts present tetanus toxoid antigen to antigen-specific T cell clones. Journal Of Clinical Investigation 1985, 76: 254-260. PMID: 3160726, PMCID: PMC423759, DOI: 10.1172/jci111955.Peer-Reviewed Original ResearchConceptsAntigen-presenting cellsTetanus toxoidProliferative responseClassical antigen-presenting cellsAntigen-specific proliferative responsesAntigen-specific T cell clonesHLA-DR antigensHelper T cellsTetanus toxoid antigenT cell proliferationT cell clonesHuman dermal fibroblastsPresent tetanus toxoidMonoclonal antibody OKM1Cultured human dermal fibroblastsDermal fibroblastsLeu-M1DR expressionHLA-DRUbiquitous cell typeAntigen presentationT cellsToxoid antigenSephadex G10 columnImmune interferon