2022
Costimulators expressed on human endothelial cells modulate antigen-dependent recruitment of circulating T lymphocytes
Manes TD, Wang V, Pober JS. Costimulators expressed on human endothelial cells modulate antigen-dependent recruitment of circulating T lymphocytes. Frontiers In Immunology 2022, 13: 1016361. PMID: 36275645, PMCID: PMC9582530, DOI: 10.3389/fimmu.2022.1016361.Peer-Reviewed Original ResearchConceptsT effector cellsT cellsTransendothelial migrationEndothelial cellsCheckpoint inhibitorsEffector cellsCytokine productionCytokine synthesisPeripheral blood T cell subpopulationsEffector memory T cellsEngagement of OX40Presentation of superantigensRegulatory T cellsMemory T cellsT cell subpopulationsT-cell typeT cell CD28Antigen-independent signalT cell activationT cell receptorHuman dermal microvascularCD8 effectorsT-regsHuman endothelial cellsActivated CD4
2003
Combining altered levels of effector transcripts in circulating T cells with a marker of endothelial injury is specific for active graft-versus-host disease
Biedermann BC, Tsakiris DA, Gregor M, Pober JS, Gratwohl A. Combining altered levels of effector transcripts in circulating T cells with a marker of endothelial injury is specific for active graft-versus-host disease. Bone Marrow Transplantation 2003, 32: 1077-1084. PMID: 14625579, DOI: 10.1038/sj.bmt.1704258.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkersCase-Control StudiesEndothelium, VascularFas Ligand ProteinGraft vs Host DiseaseHematopoietic Stem Cell TransplantationInterferon-gammaLymphocyte ActivationMembrane GlycoproteinsMolecular Diagnostic TechniquesRNA, MessengerSensitivity and SpecificitySurvivorsT-Lymphocytes, CytotoxicTransplantation, HomologousVon Willebrand FactorConceptsCytotoxic T lymphocytesEndothelial injuryT cell activationT cellsT lymphocytesHost diseaseSCT recipientsAllogeneic stem cell transplantationAllospecific cytotoxic T lymphocytesIFN-γ transcript levelsActive chronic GVHDEndothelial injury resultsCD8 T lymphocytesCD8 T cellsCD4 T cellsLong-term survivorsStem cell transplantationImportant effector cellsVon Willebrand factor plasma levelsAge-matched controlsVascular endothelial cellsChronic GVHDActive graftEffector cellsCell transplantation
1999
Immunobiology of human vascular endothelium
Pober J. Immunobiology of human vascular endothelium. Immunologic Research 1999, 19: 225-232. PMID: 10493176, DOI: 10.1007/bf02786490.Peer-Reviewed Original ResearchConceptsVascular endothelial cellsEndothelial cellsImmune reactionsCell-mediated immune reactionsPeptide-major histocompatibility complex complexesImmune effector mechanismsMemory T cellsSecondary immune reactionT cell signalsConsequences of infectionHuman vascular endotheliumHuman T lymphocytesHuman tissue specimensAllograft rejectionIntravascular coagulationAllogeneic transplantationEffector cellsNew effector functionsEffector mechanismsLeukocyte recruitmentImmune surveillanceT cellsT lymphocytesPeripheral tissuesEffector functions
1986
Physiologic Regulation of Class II Major Histocompatibility Complex Gene Expression
Collins T, Pober J, Strominger J. Physiologic Regulation of Class II Major Histocompatibility Complex Gene Expression. 1986, 14-31. DOI: 10.1007/978-3-642-70367-6_2.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsClass II determinantsNominal antigenMajor histocompatibility complexSpecific effector cellsClass II major histocompatibility complexT helper cellsAntigen-presenting cellsClass II antigensCase of transplantationMajor histocompatibility complex gene expressionT-inducer cellsClass II major histocompatibility complex gene expressionT cell antigen receptorAccessory capacityEffector cellsAllogeneic responseHelper cellsInducer cellsII antigensImmune responsivenessImmune systemCell antigen receptorAntigenAntigen receptorHistocompatibility complex