2020
Complement Membrane Attack Complex New Roles, Mechanisms of Action, and Therapeutic Targets
Xie CB, Jane-Wit D, Pober JS. Complement Membrane Attack Complex New Roles, Mechanisms of Action, and Therapeutic Targets. American Journal Of Pathology 2020, 190: 1138-1150. PMID: 32194049, PMCID: PMC7280757, DOI: 10.1016/j.ajpath.2020.02.006.Peer-Reviewed Original ResearchConceptsMembrane attack complexMAC assemblyExpression of inhibitorMechanism of actionFacilitate secretionDependent transcriptionPlasma membraneIntracellular signalingComplement membrane attack complexAbsence of lysisSignalingRecent insightsBiophysical propertiesComplement-mediated diseasesAttack complexTherapeutic targetCell activationDisease pathogenesisAdaptive immunityNew roleIL-18IL-1βCytolytic effectorsProinflammatory effectsProinflammatory proteins
2016
Complement C5 Inhibition Reduces T Cell–Mediated Allograft Vasculopathy Caused by Both Alloantibody and Ischemia Reperfusion Injury in Humanized Mice
Qin L, Li G, Kirkiles‐Smith N, Clark P, Fang C, Wang Y, Yu Z, Devore D, Tellides G, Pober J, Jane‐Wit D. Complement C5 Inhibition Reduces T Cell–Mediated Allograft Vasculopathy Caused by Both Alloantibody and Ischemia Reperfusion Injury in Humanized Mice. American Journal Of Transplantation 2016, 16: 2865-2876. PMID: 27104811, PMCID: PMC5075274, DOI: 10.1111/ajt.13834.Peer-Reviewed Original ResearchConceptsIschemia-reperfusion injuryAllograft vasculopathyEndothelial cell activationReperfusion injuryCell activationComplement C5 inhibitionNuclear factor kappa BSolid organ transplantsT cell infiltrationTerminal complement activationVCAM-1 expressionComplement C5 activationFactor kappa BNeutrophil infiltrationHumanized miceDiffuse stenosisIntraluminal thrombosisArterial graftsC5 inhibitionCell infiltrationHumanized modelNeointimal hyperplasiaOrgan transplantsAlloantibodiesNF-kB
2001
Endothelial cell activation by tumor necrosis factor elicits human antiporcine cell-mediated rejection responses
Kirkiles-Smith NC, Tereb DA, Kim RW, McNiff JM, Schechner JS, Lorber MI, Pober JS, Tellides G. Endothelial cell activation by tumor necrosis factor elicits human antiporcine cell-mediated rejection responses. Transplantation Proceedings 2001, 33: 412-413. PMID: 11266888, DOI: 10.1016/s0041-1345(00)02072-8.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsCytokinesEndothelium, VascularGraft RejectionHistocompatibility Antigens Class IHistocompatibility Antigens Class IIHumansLymphocyte ActivationMiceMice, SCIDModels, AnimalSkin TransplantationSpecies SpecificitySwineT-LymphocytesTransplantation ChimeraTransplantation ToleranceTransplantation, HeterologousTumor Necrosis Factor-alphaConceptsTumor necrosis factorEndothelial cell activationNecrosis factorCell activationRejection response
1995
Disparate localization of 55-kd and 75-kd tumor necrosis factor receptors in human endothelial cells.
Bradley JR, Thiru S, Pober JS. Disparate localization of 55-kd and 75-kd tumor necrosis factor receptors in human endothelial cells. American Journal Of Pathology 1995, 146: 27-32. PMID: 7856733, PMCID: PMC1870772.Peer-Reviewed Original ResearchConceptsTumor necrosis factor receptorNecrosis factor receptorCell surfaceFactor receptorConfocal immunofluorescence microscopyDisparate localizationUndergoes endocytosisCultured human umbilical vein endothelial cellsHuman umbilical vein endothelial cellsEndothelial cellsUmbilical vein endothelial cellsReceptor clusteringGolgi apparatusHuman endothelial cellsCoated vesiclesVein endothelial cellsImmunofluorescence microscopyCellular distributionTNF receptorEndothelial cell activationCell activationReceptorsCytoplasmic vacuolesCellsEndocytosis
1993
Costimulation of peripheral blood T cell activation by human endothelial cells. Enhanced IL-2 transcription correlates with increased c-fos synthesis and increased Fos content of AP-1.
Hughes CC, Pober JS. Costimulation of peripheral blood T cell activation by human endothelial cells. Enhanced IL-2 transcription correlates with increased c-fos synthesis and increased Fos content of AP-1. The Journal Of Immunology 1993, 150: 3148-60. PMID: 8468462, DOI: 10.4049/jimmunol.150.8.3148.Peer-Reviewed Original ResearchConceptsC-fos mRNAIL-2 transcriptionNuclear factorT cellsTranscription factor AP-1PHA activationPeripheral blood T cell activationAP-1Blood T cell activationFactor AP-1C-fosC-JunIL-2 productionHuman umbilical vein ECT cell activationIL-2 mRNAC-Fos proteinEC costimulationEndothelial cells (EC) actAllograft rejectionHuman endothelial cellsIL-2 regulationCostimulatory signalsCell activationKey molecular mechanisms
1991
Immunologic Interactions of T Lymphocytes with Vascular Endothelium
Pober J, Cotran R. Immunologic Interactions of T Lymphocytes with Vascular Endothelium. Advances In Immunology 1991, 50: 261-302. PMID: 1950797, DOI: 10.1016/s0065-2776(08)60827-5.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMemory T cellsT cellsVascular endotheliumPrimary antigen-presenting cellsAntigen-presenting functionAntigen-presenting cellsNaive T cellsContext of transplantationEffective T cell activationCultured human endothelial cellsT cell activationVivo immune systemLymph nodesHuman endothelial cellsHypersensitivity reactionsImmunologic interactionsIL-8Preferential homingT lymphocytesInflammatory sitesAntigen specificityImmune systemRejection reactionCell activationMemory responses
1989
ENDOTHELIAL CELL ACTIVATION AND HIGH INTERLEUKIN-1 SECRETION IN THE PATHOGENESIS OF ACUTE KAWASAKI DISEASE
Leung D, Kurt-Jones E, Newburger J, Cotran R, Burns J, Pober J. ENDOTHELIAL CELL ACTIVATION AND HIGH INTERLEUKIN-1 SECRETION IN THE PATHOGENESIS OF ACUTE KAWASAKI DISEASE. The Lancet 1989, 334: 1298-1302. PMID: 2480498, DOI: 10.1016/s0140-6736(89)91910-7.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, SurfaceCell AdhesionCell Adhesion MoleculesChild, PreschoolEndothelium, VascularE-SelectinFemaleGamma-GlobulinsHLA-DQ AntigensHumansImmunization, PassiveIntercellular Adhesion Molecule-1Interleukin-1MaleMembrane GlycoproteinsMucocutaneous Lymph Node SyndromeReceptors, ImmunologicSkinConceptsEndothelial cell activationCoronary artery abnormalitiesCell activationInterleukin-1Gammaglobulin treatmentArtery abnormalitiesKawasaki diseaseAcute Kawasaki disease patientsPeripheral blood mononuclear cellsEndothelial cellsCytotoxic antibody activityIntravenous gammaglobulin treatmentKawasaki disease patientsAcute Kawasaki diseaseEndothelial cell antigensBlood mononuclear cellsInterleukin-1 secretionTumor necrosis factorIL-1 secretionEndothelial cell expressionSkin biopsy samplesMeans of immunoperoxidaseMucocutaneous symptomsPersistent feverClinical symptoms
1988
Warner-Lambert/Parke-Davis award lecture. Cytokine-mediated activation of vascular endothelium. Physiology and pathology.
Pober JS. Warner-Lambert/Parke-Davis award lecture. Cytokine-mediated activation of vascular endothelium. Physiology and pathology. American Journal Of Pathology 1988, 133: 426-33. PMID: 2462353, PMCID: PMC1880803.Peer-Reviewed Original ResearchConceptsEndothelial cell activationCell activationMolecular biologic techniquesEndothelial cell functionClinical studiesMorphologic definitionVascular endotheliumBiologic techniquesPatient-based clinical researchClinical researchBiologic definitionVivo studiesHarmful sequencesCell functionDysfunctionInjuryActivationRecent studiesEndothelial activation during interleukin 2 immunotherapy. A possible mechanism for the vascular leak syndrome.
Cotran RS, Pober JS, Gimbrone MA, Springer TA, Wiebke EA, Gaspari AA, Rosenberg SA, Lotze MT. Endothelial activation during interleukin 2 immunotherapy. A possible mechanism for the vascular leak syndrome. The Journal Of Immunology 1988, 140: 1883-8. PMID: 3279124, DOI: 10.4049/jimmunol.140.6.1883.Peer-Reviewed Original ResearchConceptsIntercellular adhesion molecule-1Adhesion molecule-1Endothelial cell activationVascular leak syndromeEndothelial leukocyte adhesion molecule-1Leak syndromeMolecule-1IL-2Cell activationCultured endothelial cellsEndothelial expressionImmune responseEndothelial leukocyte adhesion molecule-1 expressionLeu-10Cell-mediated immune responsesAdhesion molecule-1 expressionEndothelial cellsDifferent activation antigensInterleukin-2 immunotherapyPost-treatment skinIL-2 therapyPostcapillary venular endotheliumMolecule-1 expressionIL-2 actsDays of treatment