2024
Test and treat approach for tuberculosis infection amongst household contacts of drug-susceptible pulmonary tuberculosis, Mumbai, India
Shah D, Bhide S, Deshmukh R, Smith J, Kaiplyawar S, Puri V, Yeldandi V, Date A, Nyendak M, Ho C, Moonan P. Test and treat approach for tuberculosis infection amongst household contacts of drug-susceptible pulmonary tuberculosis, Mumbai, India. Frontiers In Tuberculosis 2024, 2: 1454277. PMID: 39421397, PMCID: PMC11485165, DOI: 10.3389/ftubr.2024.1454277.Peer-Reviewed Original ResearchInterferon-gamma release assayTB preventive treatmentTB infectionHousehold contactsDrug-susceptible pulmonary tuberculosisTB diseaseTreat approachProgression to active TB diseaseDrug-susceptible pulmonary TBRate of TB infectionPrevalence of TB infectionActive TB diseaseAge 5 yearsSecondary TB casesCross-sectional studyAntituberculosis treatmentIGRA testPulmonary TBPulmonary tuberculosisTuberculosis infectionInterferon-gammaRelease assayClinical evaluationEarly diagnosisTreat strategyExhaled breath analysis: A promising triage test for tuberculosis in young children
Bijker E, Smith J, Mchembere W, McCarthy K, Oord H, Gerritsen J, Click E, Cain K, Song R. Exhaled breath analysis: A promising triage test for tuberculosis in young children. Tuberculosis 2024, 149: 102566. PMID: 39332067, DOI: 10.1016/j.tube.2024.102566.Peer-Reviewed Original ResearchTriage testPaediatric pulmonary tuberculosisRespiratory tract infectionsSymptoms of tuberculosisDiagnose respiratory tract infectionsCross-sectional studyExpectorated sputumTract infectionsPulmonary tuberculosisPaediatric tuberculosisDiagnostic accuracyBreath testYoung childrenYoung infantsTuberculosisExhaled breath analysisBreathingBreath analysisChildrenTriageExhaled breathSputumInfantsFeasibility and utility of a combined nasogastric-tube-and-string-test device for bacteriologic confirmation of pulmonary tuberculosis in young children
Khambati N, Song R, Smith J, Bijker E, McCarthy K, Click E, Mchembere W, Okumu A, Musau S, Okeyo E, Perez-Velez C, Cain K. Feasibility and utility of a combined nasogastric-tube-and-string-test device for bacteriologic confirmation of pulmonary tuberculosis in young children. Diagnostic Microbiology And Infectious Disease 2024, 109: 116302. PMID: 38657352, PMCID: PMC11128341, DOI: 10.1016/j.diagmicrobio.2024.116302.Peer-Reviewed Original ResearchTuberculosis Preventive Treatment Update — U.S. President’s Emergency Plan for AIDS Relief, 36 Countries, 2016–2023
Ajiboye A, O’Connor S, Smith J, Ahmedov S, Coggin W, Charles M, Ghosh S, Pierre P, Shah N, Teran R, Moonan P, Date A. Tuberculosis Preventive Treatment Update — U.S. President’s Emergency Plan for AIDS Relief, 36 Countries, 2016–2023. MMWR Morbidity And Mortality Weekly Report 2024, 73: 233-238. PMID: 38512767, PMCID: PMC10967683, DOI: 10.15585/mmwr.mm7311a1.Peer-Reviewed Original ResearchConceptsU.S. President's Emergency PlanPresident's Emergency Plan for AIDS ReliefTB preventive treatmentAIDS ReliefAntiretroviral treatmentU.S. President's Emergency Plan for AIDS ReliefElectronic medical record systemPresident's Emergency PlanPatient-centered approachFiscal yearNational HIV programTB-attributed deathsMedical record systemTB-related deathsOverall completion rateHIV programsCompletion ratesRecording systemTB diseaseStandard of careHIVHigh riskPersonsEmergency planningShorter regimensLong-term follow-up of persons diagnosed with multidrug-resistant TB in Chennai, India, 2013–2020
Surie D, Sathyanarayanan M, Lavanya J, Smith J, Shanmugam S, Tamilzhalagan S, Selvaraj A, Ramesh G, Tripathy S, Khaparde S, Ho C, Hall-Eidson P, Ranganathan U, Selvaraju S, Moonan P. Long-term follow-up of persons diagnosed with multidrug-resistant TB in Chennai, India, 2013–2020. The International Journal Of Tuberculosis And Lung Disease 2024, 28: 54-56. PMID: 38178300, PMCID: PMC10859871, DOI: 10.5588/ijtld.23.0272.Peer-Reviewed Original Research
2023
Machine learning to predict bacteriologic confirmation of Mycobacterium tuberculosis in infants and very young children
Smith J, Milligan K, McCarthy K, Mchembere W, Okeyo E, Musau S, Okumu A, Song R, Click E, Cain K. Machine learning to predict bacteriologic confirmation of Mycobacterium tuberculosis in infants and very young children. PLOS Digital Health 2023, 2: e0000249. PMID: 37195976, PMCID: PMC10191346, DOI: 10.1371/journal.pdig.0000249.Peer-Reviewed Original ResearchMicrobial confirmationTB diseaseYoung childrenNoninvasive procedureLarge prospective cohortCases of tuberculosisChest X-rayDiagnosis of tuberculosisClinical decision makingBacteriologic confirmationHousehold contactsTB infectionProspective cohortRadiologic factorsPaucibacillary natureClinical similaritiesDiagnostic cohortClinical diseaseChildhood diseasesInvasive proceduresNovel biomarkersTuberculosisClinical researchM. tuberculosisDiseaseRetaining Patients with Drug-Resistant Tuberculosis on Treatment During the COVID-19 Pandemic — Dharavi, Mumbai, India, 2020–2022
Gomare M, Bhide S, Deshmukh R, Kaipilyawar S, Puri V, Moonan P, Khetade D, Nyendak M, Yeldandi V, Smith J, Tobias J, Date A, Joshi R, Kumar R, Ho C. Retaining Patients with Drug-Resistant Tuberculosis on Treatment During the COVID-19 Pandemic — Dharavi, Mumbai, India, 2020–2022. MMWR Morbidity And Mortality Weekly Report 2023, 72: 304-308. PMID: 36952291, PMCID: PMC10042620, DOI: 10.15585/mmwr.mm7212a2.Peer-Reviewed Original ResearchIsolation and Quarantine for Coronavirus Disease 2019 in the United States, 2020–2022
Oeltmann J, Vohra D, Matulewicz H, DeLuca N, Smith J, Couzens C, Lash R, Harvey B, Boyette M, Edwards A, Talboy P, Dubose O, Regan P, Loosier P, Caruso E, Katz D, Taylor M, Moonan P. Isolation and Quarantine for Coronavirus Disease 2019 in the United States, 2020–2022. Clinical Infectious Diseases 2023, 77: 212-219. PMID: 36947142, PMCID: PMC11094624, DOI: 10.1093/cid/ciad163.Peer-Reviewed Original ResearchConceptsCoronavirus disease 2019Case patientsDisease 2019Positive severe acute respiratory syndrome coronavirus 2 test resultAdult case patientsCase investigationCOVID-19Public health programsPublic health workforceHealth programsHealth workforceContact tracingPatientsHealth officialsMost adultsAdultsDaysImpact of contactRepresentative sampleTotalMore adultsPanel SurveyQuarantineDevelopment of treatment-decision algorithms for children evaluated for pulmonary tuberculosis: an individual participant data meta-analysis
Gunasekera K, Marcy O, Muñoz J, Lopez-Varela E, Sekadde M, Franke M, Bonnet M, Ahmed S, Amanullah F, Anwar A, Augusto O, Aurilio R, Banu S, Batool I, Brands A, Cain K, Carratalá-Castro L, Caws M, Click E, Cranmer L, García-Basteiro A, Hesseling A, Huynh J, Kabir S, Lecca L, Mandalakas A, Mavhunga F, Myint A, Myo K, Nampijja D, Nicol M, Orikiriza P, Palmer M, Sant'Anna C, Siddiqui S, Smith J, Song R, Thuong Thuong N, Ung V, van der Zalm M, Verkuijl S, Viney K, Walters E, Warren J, Zar H, Marais B, Graham S, Debray T, Cohen T, Seddon J. Development of treatment-decision algorithms for children evaluated for pulmonary tuberculosis: an individual participant data meta-analysis. The Lancet Child & Adolescent Health 2023, 7: 336-346. PMID: 36924781, PMCID: PMC10127218, DOI: 10.1016/s2352-4642(23)00004-4.Peer-Reviewed Original ResearchConceptsTreatment decision algorithmsPrimary health care settingsIndividual participant dataHigh tuberculosis incidencePulmonary tuberculosisManagement of tuberculosisHealth care centersComposite reference standardHealth care settingsClinical featuresTuberculosis incidenceClinical evaluationParticipant dataTreatment decisionsChest X-ray featuresPrimary health care centersFuture prospective evaluationTuberculosis-related mortalityEvidence-based algorithmChest X-rayVariable diagnostic performanceMultivariable prediction modelReference standardEvidence-based approachTuberculosis experts
2022
HIGH-RESOLUTION CHARACTERIZATION OF NOSOCOMIAL MYCOBACTERIUM TUBERCULOSIS TRANSMISSION EVENTS IN BOTSWANA
Smith J, Modongo C, Oeltmann J, Dima M, Matsiri O, Fane O, Molefi T, Shin S, Barilar I, Niemann S, Zetola N, Moonan P. HIGH-RESOLUTION CHARACTERIZATION OF NOSOCOMIAL MYCOBACTERIUM TUBERCULOSIS TRANSMISSION EVENTS IN BOTSWANA. American Journal Of Epidemiology 2022, 192: 503-506. PMID: 36549903, PMCID: PMC10372855, DOI: 10.1093/aje/kwac214.Peer-Reviewed Original ResearchClinical and Radiologic Factors Associated With Detection of Mycobacterium tuberculosis in Children Under 5 Years old Using Invasive and Noninvasive Sample Collection Techniques—Kenya
Smith J, Song R, McCarthy K, Mchembere W, Click E, Cain K. Clinical and Radiologic Factors Associated With Detection of Mycobacterium tuberculosis in Children Under 5 Years old Using Invasive and Noninvasive Sample Collection Techniques—Kenya. Open Forum Infectious Diseases 2022, 9: ofac560. PMID: 36386048, PMCID: PMC9664973, DOI: 10.1093/ofid/ofac560.Peer-Reviewed Original ResearchSpecimen collection techniquesRadiologic factorsYoung childrenProspective cohort studyFine-needle aspirationHistory of exposurePublic health concernCritical public health concernBacteriologic confirmationAirway compressionCervical lymphadenopathyRadiological factorsCohort studyPediatric tuberculosisTB casesPresumptive tuberculosisClinical managementImmunologic evidenceNeedle aspirationPositive specimenDiagnostic testingTuberculosisLogistic regressionHealth concernMycobacterium tuberculosisQuantifying Mycobacterium tuberculosis Transmission Dynamics Across Global Settings: A Systematic Analysis
Smith J, Cohen T, Dowdy D, Shrestha S, Gandhi NR, Hill AN. Quantifying Mycobacterium tuberculosis Transmission Dynamics Across Global Settings: A Systematic Analysis. American Journal Of Epidemiology 2022, 192: 133-145. PMID: 36227246, PMCID: PMC10144641, DOI: 10.1093/aje/kwac181.Peer-Reviewed Original ResearchConceptsTB transmissionOngoing TB transmissionMinority of casesTuberculosis transmission dynamicsTB controlTuberculosis transmissionSecondary casesSources of heterogeneityInclusion criteriaSurveillance studyTransmission clustersInitial searchTransmission dynamicsWhole-genome sequencingPopulation levelSettingYes, it matters who is spreading monkeypox
Smith J. Yes, it matters who is spreading monkeypox. The Lancet Infectious Diseases 2022, 22: 1416-1417. PMID: 36152654, PMCID: PMC9533935, DOI: 10.1016/s1473-3099(22)00579-5.Peer-Reviewed Original ResearchPerformance of Xpert MTB/RIF and Mycobacterial Culture on Multiple Specimen Types for Diagnosis of Tuberculosis Disease in Young Children and Clinical Characterization According to Standardized Research Case Definitions
Click ES, Song R, Smith JP, Mchembere W, Fajans M, Hariri P, Okeyo E, McCarthy KD, Gethi D, Odeny L, Musau S, Okumu A, Orwa J, Perez-Velez CM, Wright CA, Andres M, Marais BJ, Schaaf HS, Graham SM, Cruz AT, Cain KP. Performance of Xpert MTB/RIF and Mycobacterial Culture on Multiple Specimen Types for Diagnosis of Tuberculosis Disease in Young Children and Clinical Characterization According to Standardized Research Case Definitions. The Pediatric Infectious Disease Journal 2022, 41: 671-677. PMID: 35703284, PMCID: PMC9288526, DOI: 10.1097/inf.0000000000003582.Peer-Reviewed Original ResearchConceptsXpert MTB/RIFResearch case definitionClinical case definitionMTB/RIFCase definitionIntrathoracic tuberculosisClinical characterizationMycobacterial cultureYoung childrenProspective cohort studyDifferent specimen typesDetailed clinical characterizationMultiple specimen typesSpecimen typesClinical diagnostic approachTB diseaseCohort studyMycobacterium tuberculosis complexParenchymal abnormalitiesConsecutive seriesOutpatient settingTuberculosis diseaseLeading causeXpert testChest radiographsEpidemiology beyond its limits
McCullough LE, Maliniak ML, Amin AB, Baker JM, Baliashvili D, Barberio J, Barrera CM, Brown CA, Collin LJ, Freedman AA, Gibbs DC, Haddad MB, Hall EW, Hamid S, Harrington KRV, Holleman AM, Kaufman JA, Khan MA, Labgold K, Lee VC, Malik AA, Mann LM, Marks KJ, Nelson KN, Quader ZS, Ross-Driscoll K, Sarkar S, Shah MP, Shao IY, Smith JP, Stanhope KK, Valenzuela-Lara M, Van Dyke ME, Vyas KJ, Lash TL. Epidemiology beyond its limits. Science Advances 2022, 8: eabn3328. PMID: 35675391, PMCID: PMC9176748, DOI: 10.1126/sciadv.abn3328.Peer-Reviewed Original ResearchCharacterizing tuberculosis transmission dynamics in high-burden urban and rural settings
Smith JP, Oeltmann JE, Hill AN, Tobias JL, Boyd R, Click ES, Finlay A, Mondongo C, Zetola NM, Moonan PK. Characterizing tuberculosis transmission dynamics in high-burden urban and rural settings. Scientific Reports 2022, 12: 6780. PMID: 35474076, PMCID: PMC9042872, DOI: 10.1038/s41598-022-10488-2.Peer-Reviewed Original ResearchConceptsTuberculosis transmission dynamicsHigh TB burden countriesPopulation-based molecular epidemiology studiesLocal TB epidemiologyHigh-burden settingsTB burden countriesRural settingsTransmission dynamicsRural populationMolecular epidemiology studiesBurden countriesEffective reproductive numberIncident casesTB epidemiologyTB transmissionMedian numberSecondary casesInfectious casesEpidemiology studiesFirst outbreakReproductive numberSecondary transmissionPopulationCritical roleSettingZambia Assessment of Tuberculosis (TB) and HIV in the Mines (ZATHIM): implications for programs and policies
Podewils LJ, Long EF, Fuller TJ, Mwakazanga D, Kapungu K, Tembo M, Mwanza S, Curran KG, Smith JP, Tobias JL, Kasongo W. Zambia Assessment of Tuberculosis (TB) and HIV in the Mines (ZATHIM): implications for programs and policies. BMC Public Health 2022, 22: 791. PMID: 35439984, PMCID: PMC9018205, DOI: 10.1186/s12889-022-13053-8.Peer-Reviewed Original ResearchConceptsHealthcare workersTB symptomsMore TB symptomsFocus group discussionsDiagnosis of tuberculosisTB diseaseTB careTB statusMixed-method evaluationAppropriate careKey populationsReporting 2TuberculosisKAP surveyAssess knowledgeHigh-quality healthcare servicesHealthcare servicesCareHealthy livingHIVHigh rateSymptomsDiagnosisMajor barrierCurrent evaluationTuberculosis attributed to transmission within healthcare facilities, Botswana—The Kopanyo Study
Smith JP, Modongo C, Moonan PK, Dima M, Matsiri O, Fane O, Click ES, Boyd R, Finlay A, Surie D, Tobias JL, Zetola NM, Oeltmann JE. Tuberculosis attributed to transmission within healthcare facilities, Botswana—The Kopanyo Study. Infection Control And Hospital Epidemiology 2022, 43: 1603-1609. PMID: 35382909, PMCID: PMC9535034, DOI: 10.1017/ice.2021.517.Peer-Reviewed Original ResearchConceptsElectronic medical recordsHealthcare facilitiesPopulation-based molecular epidemiologic studyMolecular epidemiologic studiesTB casesTB diagnosisTB transmissionTB epidemicMedical recordsTuberculosis diseaseBiologic plausibilityHealthcare workersIndividual patientsEpidemiologic studiesGeneral populationCommunity transmissionEtiologic agentTreatment dataClinical encountersPatientsEffective interventionsIndividual riskEMR dataTransmission eventsHigh-risk environmentsModel-based Analysis of Tuberculosis Genotype Clusters in the United States Reveals High Degree of Heterogeneity in Transmission and State-level Differences Across California, Florida, New York, and Texas
Shrestha S, Winglee K, Hill A, Shaw T, Smith J, Kammerer JS, Silk BJ, Marks S, Dowdy D. Model-based Analysis of Tuberculosis Genotype Clusters in the United States Reveals High Degree of Heterogeneity in Transmission and State-level Differences Across California, Florida, New York, and Texas. Clinical Infectious Diseases 2022, 75: 1433-1441. PMID: 35143641, PMCID: PMC9412192, DOI: 10.1093/cid/ciac121.Peer-Reviewed Original ResearchConceptsTB casesTB transmissionKey public health priorityPublic health priorityMechanistic transmission modelsTB incidenceTuberculosis transmissionSecondary casesHealth priorityInfectious casesTransmission clustersDisease controlMean numberR0 estimatesUnited StatesWhole-genome sequencingSame countyGenotype clustersState-level differencesSecondary transmissionCasesIncidence
2021
A Cluster-based Method to Quantify Individual Heterogeneity in Tuberculosis Transmission
Smith JP, Gandhi NR, Silk BJ, Cohen T, Lopman B, Raz K, Winglee K, Kammerer S, Benkeser D, Kramer MR, Hill AN. A Cluster-based Method to Quantify Individual Heterogeneity in Tuberculosis Transmission. Epidemiology 2021, 33: 217-227. PMID: 34907974, PMCID: PMC8886690, DOI: 10.1097/ede.0000000000001452.Peer-Reviewed Original Research