Characterizing tuberculosis transmission dynamics in high-burden urban and rural settings
Smith JP, Oeltmann JE, Hill AN, Tobias JL, Boyd R, Click ES, Finlay A, Mondongo C, Zetola NM, Moonan PK. Characterizing tuberculosis transmission dynamics in high-burden urban and rural settings. Scientific Reports 2022, 12: 6780. PMID: 35474076, PMCID: PMC9042872, DOI: 10.1038/s41598-022-10488-2.Peer-Reviewed Original ResearchConceptsTuberculosis transmission dynamicsHigh TB burden countriesPopulation-based molecular epidemiology studiesLocal TB epidemiologyHigh-burden settingsTB burden countriesRural settingsTransmission dynamicsRural populationMolecular epidemiology studiesBurden countriesEffective reproductive numberIncident casesTB epidemiologyTB transmissionMedian numberSecondary casesInfectious casesEpidemiology studiesFirst outbreakReproductive numberSecondary transmissionPopulationCritical roleSettingModel-based Analysis of Tuberculosis Genotype Clusters in the United States Reveals High Degree of Heterogeneity in Transmission and State-level Differences Across California, Florida, New York, and Texas
Shrestha S, Winglee K, Hill A, Shaw T, Smith J, Kammerer JS, Silk BJ, Marks S, Dowdy D. Model-based Analysis of Tuberculosis Genotype Clusters in the United States Reveals High Degree of Heterogeneity in Transmission and State-level Differences Across California, Florida, New York, and Texas. Clinical Infectious Diseases 2022, 75: 1433-1441. PMID: 35143641, PMCID: PMC9412192, DOI: 10.1093/cid/ciac121.Peer-Reviewed Original ResearchConceptsTB casesTB transmissionKey public health priorityPublic health priorityMechanistic transmission modelsTB incidenceTuberculosis transmissionSecondary casesHealth priorityInfectious casesTransmission clustersDisease controlMean numberR0 estimatesUnited StatesWhole-genome sequencingSame countyGenotype clustersState-level differencesSecondary transmissionCasesIncidence