2024
Feasibility and utility of a combined nasogastric-tube-and-string-test device for bacteriologic confirmation of pulmonary tuberculosis in young children
Khambati N, Song R, Smith J, Bijker E, McCarthy K, Click E, Mchembere W, Okumu A, Musau S, Okeyo E, Perez-Velez C, Cain K. Feasibility and utility of a combined nasogastric-tube-and-string-test device for bacteriologic confirmation of pulmonary tuberculosis in young children. Diagnostic Microbiology And Infectious Disease 2024, 109: 116302. PMID: 38657352, PMCID: PMC11128341, DOI: 10.1016/j.diagmicrobio.2024.116302.Peer-Reviewed Original Research
2022
Clinical and Radiologic Factors Associated With Detection of Mycobacterium tuberculosis in Children Under 5 Years old Using Invasive and Noninvasive Sample Collection Techniques—Kenya
Smith J, Song R, McCarthy K, Mchembere W, Click E, Cain K. Clinical and Radiologic Factors Associated With Detection of Mycobacterium tuberculosis in Children Under 5 Years old Using Invasive and Noninvasive Sample Collection Techniques—Kenya. Open Forum Infectious Diseases 2022, 9: ofac560. PMID: 36386048, PMCID: PMC9664973, DOI: 10.1093/ofid/ofac560.Peer-Reviewed Original ResearchSpecimen collection techniquesRadiologic factorsYoung childrenProspective cohort studyFine-needle aspirationHistory of exposurePublic health concernCritical public health concernBacteriologic confirmationAirway compressionCervical lymphadenopathyRadiological factorsCohort studyPediatric tuberculosisTB casesPresumptive tuberculosisClinical managementImmunologic evidenceNeedle aspirationPositive specimenDiagnostic testingTuberculosisLogistic regressionHealth concernMycobacterium tuberculosisPerformance of Xpert MTB/RIF and Mycobacterial Culture on Multiple Specimen Types for Diagnosis of Tuberculosis Disease in Young Children and Clinical Characterization According to Standardized Research Case Definitions
Click ES, Song R, Smith JP, Mchembere W, Fajans M, Hariri P, Okeyo E, McCarthy KD, Gethi D, Odeny L, Musau S, Okumu A, Orwa J, Perez-Velez CM, Wright CA, Andres M, Marais BJ, Schaaf HS, Graham SM, Cruz AT, Cain KP. Performance of Xpert MTB/RIF and Mycobacterial Culture on Multiple Specimen Types for Diagnosis of Tuberculosis Disease in Young Children and Clinical Characterization According to Standardized Research Case Definitions. The Pediatric Infectious Disease Journal 2022, 41: 671-677. PMID: 35703284, PMCID: PMC9288526, DOI: 10.1097/inf.0000000000003582.Peer-Reviewed Original ResearchConceptsXpert MTB/RIFResearch case definitionClinical case definitionMTB/RIFCase definitionIntrathoracic tuberculosisClinical characterizationMycobacterial cultureYoung childrenProspective cohort studyDifferent specimen typesDetailed clinical characterizationMultiple specimen typesSpecimen typesClinical diagnostic approachTB diseaseCohort studyMycobacterium tuberculosis complexParenchymal abnormalitiesConsecutive seriesOutpatient settingTuberculosis diseaseLeading causeXpert testChest radiographs
2019
Lung Injury on Antiretroviral Therapy in Adults With Human Immunodeficiency Virus/Tuberculosis
Ravimohan S, Auld SC, Maenetje P, Ratsela N, Mlotshwa M, Ncube I, Smith JP, Vangu MD, Sebe M, Kossenkov A, Weissman D, Wallis RS, Churchyard G, Kornfeld H, Bisson GP. Lung Injury on Antiretroviral Therapy in Adults With Human Immunodeficiency Virus/Tuberculosis. Clinical Infectious Diseases 2019, 70: 1845-1854. PMID: 31242296, PMCID: PMC7156779, DOI: 10.1093/cid/ciz560.Peer-Reviewed Original ResearchConceptsPositron emission tomography-computed tomographyHuman immunodeficiency virusTotal glycolytic activityAntiretroviral therapyART initiationLung functionPulmonary tuberculosisLung inflammationLung injuryPulmonary inflammationMycobacteria-specific CD4 T cellsFluorodeoxyglucose positron emission tomography-computed tomographyCD4 T-cell restorationCD4 T cell functionCD4 T cell responsesEmission tomography-computed tomographyHuman immunodeficiency virus/tuberculosisTB treatment completionT-cell restorationWorse lung functionProspective cohort studyHIV/tuberculosisCD4 T cellsFDG PET-CTT cell responses