2020
Mucin-Like Domain of Ebola Virus Glycoprotein Enhances Selective Oncolytic Actions against Brain Tumors
Zhang X, Zhang T, Davis JN, Marzi A, Marchese AM, Robek MD, van den Pol AN. Mucin-Like Domain of Ebola Virus Glycoprotein Enhances Selective Oncolytic Actions against Brain Tumors. Journal Of Virology 2020, 94: 10.1128/jvi.01967-19. PMID: 32051271, PMCID: PMC7108827, DOI: 10.1128/jvi.01967-19.Peer-Reviewed Original ResearchConceptsChimeric vesicular stomatitis virusVSV-EBOVNormal brain cellsBrain tumorsVesicular stomatitis virusEBOV glycoproteinEbola virus glycoproteinEbola virusBrain cellsNormal immunocompetent miceBrain tumor-bearing miceImmunodeficient SCID miceTumor-bearing miceHuman brain tumorsSCID mouse brainStomatitis virusTranscription-quantitative PCRMost tumor cellsVirus glycoproteinOncolytic actionImmune system evasionImmunocompetent miceWild-type vesicular stomatitis virusSCID miceVirus infection
2017
Zika Virus Targeting in the Developing Brain
van den Pol AN, Mao G, Yang Y, Ornaghi S, Davis JN. Zika Virus Targeting in the Developing Brain. Journal Of Neuroscience 2017, 37: 2161-2175. PMID: 28123079, PMCID: PMC5338758, DOI: 10.1523/jneurosci.3124-16.2017.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAntiviral AgentsBrainCell Line, TransformedCells, CulturedDisease Models, AnimalGene Expression Regulation, ViralHumansImmunocompromised HostInterferonsMental DisordersMiceMice, TransgenicNervous System DiseasesNeurogliaNeuronsReceptors, InterferonZika VirusZika Virus InfectionConceptsZika virusPeripheral inoculationZIKV infectionSomatosensory cortexType 1 interferon responseContralateral somatosensory cortexSecond trimester human fetusesEarly neonatal stageDay of birthNormal mouse brainSerious neurological problemsMidline brain regionsDevelopmental mouse modelAstrocyte infectionRNA flavivirusInfected astrocytesCortical thinningOptic tractImmunocompetent miceLateral geniculateRetinal neuronsGlial cellsMouse modelNeurological problemsNewborn mice
2016
Mood stabilizers inhibit cytomegalovirus infection
Ornaghi S, Davis JN, Gorres KL, Miller G, Paidas MJ, van den Pol AN. Mood stabilizers inhibit cytomegalovirus infection. Virology 2016, 499: 121-135. PMID: 27657833, PMCID: PMC5102808, DOI: 10.1016/j.virol.2016.09.012.Peer-Reviewed Original ResearchConceptsCytomegalovirus infectionAvailable anti-CMV drugsAnti-CMV drugsCommon infectious causeCongenital birth defectsInfected newbornsFetal exposureInfectious causesInfected fetusesMood stabilizersMouse CMVMood disordersImmunocompromised individualsPsychiatric disordersBody weightViral resistanceHuman CMVDevelopmental maturationBirth defectsSpecific inhibitionCMVInfectionValnoctamideDisordersDrugs
2015
Lassa-Vesicular Stomatitis Chimeric Virus Safely Destroys Brain Tumors
Wollmann G, Drokhlyansky E, Davis JN, Cepko C, van den Pol AN. Lassa-Vesicular Stomatitis Chimeric Virus Safely Destroys Brain Tumors. Journal Of Virology 2015, 89: 6711-6724. PMID: 25878115, PMCID: PMC4468483, DOI: 10.1128/jvi.00709-15.Peer-Reviewed Original ResearchConceptsLymphocytic choriomeningitis virusBrain tumorsVesicular stomatitis virusChimeric virusesBrain cancerLassa virusEbola virusMarburg virusRabies virusAdverse neurologic consequencesExquisite tumor specificityHigh-grade tumorsPromising oncolytic virusLassa virus glycoprotein precursorAdverse side effectsTumor-bearing miceMetastatic cancer modelsStomatitis virusNovel chimeric virusHigh-grade glioblastomaEbola virus glycoproteinMultiple cancer typesNoninjected tumorNeurologic consequencesOncolytic potential