2017
Zika Virus Targeting in the Developing Brain
van den Pol AN, Mao G, Yang Y, Ornaghi S, Davis JN. Zika Virus Targeting in the Developing Brain. Journal Of Neuroscience 2017, 37: 2161-2175. PMID: 28123079, PMCID: PMC5338758, DOI: 10.1523/jneurosci.3124-16.2017.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAntiviral AgentsBrainCell Line, TransformedCells, CulturedDisease Models, AnimalGene Expression Regulation, ViralHumansImmunocompromised HostInterferonsMental DisordersMiceMice, TransgenicNervous System DiseasesNeurogliaNeuronsReceptors, InterferonZika VirusZika Virus InfectionConceptsZika virusPeripheral inoculationZIKV infectionSomatosensory cortexType 1 interferon responseContralateral somatosensory cortexSecond trimester human fetusesEarly neonatal stageDay of birthNormal mouse brainSerious neurological problemsMidline brain regionsDevelopmental mouse modelAstrocyte infectionRNA flavivirusInfected astrocytesCortical thinningOptic tractImmunocompetent miceLateral geniculateRetinal neuronsGlial cellsMouse modelNeurological problemsNewborn mice
2016
Mood stabilizers inhibit cytomegalovirus infection
Ornaghi S, Davis JN, Gorres KL, Miller G, Paidas MJ, van den Pol AN. Mood stabilizers inhibit cytomegalovirus infection. Virology 2016, 499: 121-135. PMID: 27657833, PMCID: PMC5102808, DOI: 10.1016/j.virol.2016.09.012.Peer-Reviewed Original ResearchConceptsCytomegalovirus infectionAvailable anti-CMV drugsAnti-CMV drugsCommon infectious causeCongenital birth defectsInfected newbornsFetal exposureInfectious causesInfected fetusesMood stabilizersMouse CMVMood disordersImmunocompromised individualsPsychiatric disordersBody weightViral resistanceHuman CMVDevelopmental maturationBirth defectsSpecific inhibitionCMVInfectionValnoctamideDisordersDrugs