2015
Toward Illness Phase–Specific Pharmacotherapy for Schizophrenia
Krystal JH, Anticevic A. Toward Illness Phase–Specific Pharmacotherapy for Schizophrenia. Biological Psychiatry 2015, 78: 738-740. PMID: 26542740, DOI: 10.1016/j.biopsych.2015.08.017.Peer-Reviewed Original ResearchAntipsychotic AgentsBridged Bicyclo Compounds, HeterocyclicCyclic S-OxidesFemaleHumansMaleReceptors, Metabotropic GlutamateSchizophrenia
2014
Evaluation of the sensitivity of the novel α4β2* nicotinic acetylcholine receptor PET radioligand 18F‐(‐)‐NCFHEB to increases in synaptic acetylcholine levels in rhesus monkeys
Gallezot J, Esterlis I, Bois F, Zheng M, Lin S, Kloczynski T, Krystal JH, Huang Y, Sabri O, Carson RE, Cosgrove KP. Evaluation of the sensitivity of the novel α4β2* nicotinic acetylcholine receptor PET radioligand 18F‐(‐)‐NCFHEB to increases in synaptic acetylcholine levels in rhesus monkeys. Synapse 2014, 68: 556-564. PMID: 25043426, PMCID: PMC4224280, DOI: 10.1002/syn.21767.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAnimalsBenzamidesBrainBridged Bicyclo Compounds, HeterocyclicMacaca mulattaMalePositron-Emission TomographyProtein BindingRadiopharmaceuticalsReceptors, NicotinicSensitivity and SpecificitySynapsesTissue DistributionConceptsSynaptic acetylcholine concentrationPositron emission tomographyAcetylcholine concentrationRhesus monkeysInfusion of physostigmineSynaptic acetylcholine levelsDose-dependent reductionNicotinic acetylcholine receptorsAcetylcholine levelsBolus injectionAcetylcholine receptorsAcetylcholine dynamicsNew radioligandEmission tomographyArterial input functionAcetylcholinesterase inhibitorsRadioligandThalamusPhysostigmineDonepezilΑ4β2Promising tracerBaselineMonkeysShort scan duration