2021
Characteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19
Feldstein LR, Tenforde MW, Friedman KG, Newhams M, Rose EB, Dapul H, Soma VL, Maddux AB, Mourani PM, Bowens C, Maamari M, Hall MW, Riggs BJ, Giuliano JS, Singh AR, Li S, Kong M, Schuster JE, McLaughlin GE, Schwartz SP, Walker TC, Loftis LL, Hobbs CV, Halasa NB, Doymaz S, Babbitt CJ, Hume JR, Gertz SJ, Irby K, Clouser KN, Cvijanovich NZ, Bradford TT, Smith LS, Heidemann SM, Zackai SP, Wellnitz K, Nofziger RA, Horwitz SM, Carroll RW, Rowan CM, Tarquinio KM, Mack EH, Fitzgerald JC, Coates BM, Jackson AM, Young CC, Son MBF, Patel MM, Newburger JW, Randolph AG. Characteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19. JAMA 2021, 325: 1074-1087. PMID: 33625505, PMCID: PMC7905703, DOI: 10.1001/jama.2021.2091.Peer-Reviewed Original ResearchConceptsMultisystem inflammatory syndromeOrgan system involvementInflammatory syndromeCase seriesSystem involvementCardiorespiratory involvementCOVID-19Positive severe acute respiratory syndrome coronavirus 2Higher C-reactive protein levelsPositive RT-PCR test resultsSevere acute respiratory syndrome coronavirus 2Severe acute COVID-19Acute respiratory syndrome coronavirus 2C-reactive protein levelsSevere coronavirus disease 2019Left ventricular systolic functionRT-PCR test resultsRespiratory syndrome coronavirus 2Organ system complicationsAcute COVID-19Coronary artery aneurysmsVentricular systolic functionLow platelet countAntibody test resultsIntensive care unit
2019
Angiopoietin Level Trajectories in Toddlers With Severe Sepsis and Septic Shock and Their Effect on Capillary Endothelium
Pierce RW, Shabanova V, Canarie M, Pinto M, da Silva YS, Bhandari V, Giuliano JS. Angiopoietin Level Trajectories in Toddlers With Severe Sepsis and Septic Shock and Their Effect on Capillary Endothelium. Shock 2019, 51: 298-305. PMID: 30286031, PMCID: PMC6375782, DOI: 10.1097/shk.0000000000001172.Peer-Reviewed Original ResearchConceptsSevere sepsis/septic shockSepsis/septic shockTumor necrosis factorHuman dermal microvascular endothelial cellsCultured human dermal microvascular endothelial cellsSIRS/sepsisSeptic shockAngpt-1Severe sepsisAngpt-2Diagnostic biomarkersSevere sepsis/shockTertiary care pediatric hospitalEndothelial cellsAngpt-2 levelsOlder childrenSepsis/shockInflammatory response syndromeProspective observational studyTransendothelial electrical resistance measurementsDermal microvascular endothelial cellsAppropriate diagnostic biomarkersMicrovascular endothelial cellsYoung childrenEnzyme-linked immunoassay
2014
Angiopoietin-1, Angiopoietin-2 and Bicarbonate as Diagnostic Biomarkers in Children with Severe Sepsis
Wang K, Bhandari V, Giuliano JS, O′Hern C, Shattuck MD, Kirby M. Angiopoietin-1, Angiopoietin-2 and Bicarbonate as Diagnostic Biomarkers in Children with Severe Sepsis. PLOS ONE 2014, 9: e108461. PMID: 25255212, PMCID: PMC4178003, DOI: 10.1371/journal.pone.0108461.Peer-Reviewed Original ResearchConceptsPediatric intensive care unitSepsis severityAngiopoietin-2Angiopoietin-1Severe pediatric sepsisSeverity of sepsisIntensive care unitTime of admissionHigh mortality rateSevere sepsisPediatric sepsisCare unitAng-2Ill childrenClinical dataAng-1Mortality rateSepsisSingle biomarkerDiagnostic biomarkersBiomarkersSeverityPlasma samplesMultiple biomarkersChildren