2005
The B1-subunit of the H+ ATPase is required for maximal urinary acidification
Finberg KE, Wagner CA, Bailey MA, Păunescu T, Breton S, Brown D, Giebisch G, Geibel JP, Lifton RP. The B1-subunit of the H+ ATPase is required for maximal urinary acidification. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 13616-13621. PMID: 16174750, PMCID: PMC1224669, DOI: 10.1073/pnas.0506769102.Peer-Reviewed Original ResearchConceptsMaximal urinary acidificationNormal urinary acidificationMetabolic acidosisUrinary acidificationDistal renal tubular acidosisAcid challengeRenal tubular acidosisAcute intracellular acidificationB1 subunitLumen-negative potentialFurosemide infusionTubular acidosisAlkaline urineDistal nephronGreater severityAcidosisMiceLoss of B1Intracellular acidificationApical expressionUrineDuctFurther decreaseIsoformsPlasma membrane
2004
Renal Vacuolar H+-ATPase
Wagner CA, Finberg KE, Breton S, Marshansky V, Brown D, Geibel JP. Renal Vacuolar H+-ATPase. Physiological Reviews 2004, 84: 1263-1314. PMID: 15383652, DOI: 10.1152/physrev.00045.2003.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsProximal tubular bicarbonate reabsorptionDistal renal tubular acidosisTubular bicarbonate reabsorptionRenal tubular acidosisFinal urinary acidificationTubular acidosisElectrolyte statusBicarbonate reabsorptionMonogenic defectsProximal tubulesUrinary acidificationKidneyATP-dependent transportVariety of factorsHigher numberPatientsIntracellular organellesAcidosisRegulatory proteinsLocalization patterns
2003
Localization and Regulation of the ATP6V0A4 (a4) Vacuolar H+-ATPase Subunit Defective in an Inherited Form of Distal Renal Tubular Acidosis
Stehberger PA, Schulz N, Finberg KE, Karet FE, Giebisch G, Lifton RP, Geibel JP, Wagner CA. Localization and Regulation of the ATP6V0A4 (a4) Vacuolar H+-ATPase Subunit Defective in an Inherited Form of Distal Renal Tubular Acidosis. Journal Of The American Society Of Nephrology 2003, 14: 3027-3038. PMID: 14638902, DOI: 10.1097/01.asn.0000099375.74789.ab.Peer-Reviewed Original ResearchConceptsDistal renal tubular acidosisRenal tubular acidosisLoop of HenleProximal tubulesTubular acidosisMouse kidneyA4 expressionDistal tubulesDistal convoluted tubuleProtein expression levelsElectrolyte intakeA4 proteinConvoluted tubulesMouse nephron segmentsNephron segmentsApical stainingWestern blottingAcidosisProtein expressionKidneyATPase activityDistal portionHenleExpression levelsTubules
2002
Acid-base transport in the collecting duct.
Wagner CA, Geibel JP. Acid-base transport in the collecting duct. Journal Of Nephrology 2002, 15 Suppl 5: s112-27. PMID: 12027210.Peer-Reviewed Original ResearchConceptsDistal renal tubular acidosisRisk of nephrocalcinosisAcid-base transportRenal tubular acidosisAngiotensin IIMetabolic acidosisTubular acidosisBicarbonate handlingElectrolyte statusRenal electrolyteMetabolic statusAcidosisFinal secretionDuctTranscellular movementProtein mutationsGenetic diseasesStatusBicarbonateAldosteroneCellsNephrocalcinosisEndothelinLithiasisSyndrome