2001
Prenatal cocaine exposure increases mesoprefrontal dopamine neuron responsivity to mild stress
Elsworth J, Morrow B, Roth R. Prenatal cocaine exposure increases mesoprefrontal dopamine neuron responsivity to mild stress. Synapse 2001, 42: 80-83. PMID: 11574943, DOI: 10.1002/syn.1102.Peer-Reviewed Original ResearchConceptsPrenatal cocaine exposurePrefrontal cortexCocaine exposureShort-term memory deficitsVentromedial prefrontal cortexShort-term memoryMedial prefrontal cortexDopamine neuronsAdolescent ratsCognitive deficitsMemory deficitsMesoprefrontal dopamine systemPrenatal cocaineMild footshock stressDopamine systemDeficitsFootshock stressNeurobehavioral deficitsDopamine turnoverIntravenous modelRodent modelsBehavioral abnormalitiesFetal developmentMild stressCortexPrenatal exposure to cocaine reduces the number and enhances reactivity of A10 dopaminergic neurons to environmental stress
Morrow B, Elsworth J, Roth R. Prenatal exposure to cocaine reduces the number and enhances reactivity of A10 dopaminergic neurons to environmental stress. Synapse 2001, 41: 337-344. PMID: 11494404, DOI: 10.1002/syn.1090.Peer-Reviewed Original ResearchConceptsA10 dopamine neuronsDopamine neuronsDopaminergic neuronsPrenatal exposurePrenatal saline controlsTyrosine hydroxylase immunoreactiveA10 dopaminergic neuronsCocaine-induced reductionRat dopaminergic neuronsCocaine-exposed ratsPoor cognitive performanceYoung adult offspringUnderlying biochemical changesDopaminergic functionA9 regionSaline controlsIntravenous modelPerinatal lossAdult offspringIntermittent footshockImmediate early genesCognitive deficitsNeuronal systemsBehavioral effectsCell groups
2000
The predator odor, TMT, displays a unique, stress-like pattern of dopaminergic and endocrinological activation in the rat
Morrow B, Redmond A, Roth R, Elsworth J. The predator odor, TMT, displays a unique, stress-like pattern of dopaminergic and endocrinological activation in the rat. Brain Research 2000, 864: 146-151. PMID: 10793199, DOI: 10.1016/s0006-8993(00)02174-0.Peer-Reviewed Original ResearchConceptsDopamine metabolismSerum corticosteroneAcute exposureCentral dopamine metabolismNucleus accumbens coreMedial prefrontal cortexFear-inducing behaviorPredator odorCentral effectsAccumbens coreRatsStressful stimuliPrefrontal cortexConditioned fearAltered behaviorControl odorAversive stimuliCorticosteroneMetabolismOpen fieldBiochemical activationUnique patternExposureActivationTMTDivergent effects of putative anxiolytics on stress‐induced Fos expression in the mesoprefrontal system of the rat
Morrow B, Elsworth J, Lee E, Roth R. Divergent effects of putative anxiolytics on stress‐induced Fos expression in the mesoprefrontal system of the rat. Synapse 2000, 36: 143-154. PMID: 10767061, DOI: 10.1002/(sici)1098-2396(200005)36:2<143::aid-syn7>3.0.co;2-h.Peer-Reviewed Original ResearchConceptsVentral tegmental areaFos-LITegmental areaMedial prefrontal cortexPutative anxiolyticsBenzodiazepine agonistsStress-induced Fos-like immunoreactivityPartial agonistStress-induced Fos expressionGlycine/NMDA receptorPrefrontal cortexMesoprefrontal dopamine neuronsPutative anxiolytic agentsTH-LI cellsSaline-treated ratsFos-like immunoreactivityAnxiolytic-like actionFos-LI nucleiWeak partial agonistStress-induced increaseFear-inducing behaviorFootshock paradigmAlpha2 agonistsStress-induced activationDopaminergic neurons
1999
An Antisense Oligonucleotide Reverses the Footshock-Induced Expression of Fos in the Rat Medial Prefrontal Cortex and the Subsequent Expression of Conditioned Fear-Induced Immobility
Morrow B, Elsworth J, Inglis F, Roth R. An Antisense Oligonucleotide Reverses the Footshock-Induced Expression of Fos in the Rat Medial Prefrontal Cortex and the Subsequent Expression of Conditioned Fear-Induced Immobility. Journal Of Neuroscience 1999, 19: 5666-5673. PMID: 10377372, PMCID: PMC6782327, DOI: 10.1523/jneurosci.19-13-05666.1999.Peer-Reviewed Original ResearchThe role of mesoprefrontal dopamine neurons in the acquisition and expression of conditioned fear in the rat
Morrow B, Elsworth J, Rasmusson A, Roth R. The role of mesoprefrontal dopamine neurons in the acquisition and expression of conditioned fear in the rat. Neuroscience 1999, 92: 553-564. PMID: 10408604, DOI: 10.1016/s0306-4522(99)00014-7.Peer-Reviewed Original ResearchConceptsFear conditioningMesoprefrontal dopamine neuronsClassical fear conditioningMedial prefrontal cortexDopamine neuronsFear responsesConditioned fearPrefrontal cortexFearful behaviorNormal extinctionConditioned responsePsychological stressorsRate of extinctionStress-related changesSham-lesioned ratsConditioningFearAcquisition periodDopamine metabolismNucleus accumbensDopamine levelsAcquisitionRatsNeuronsLesionsBiochemical and behavioral anxiolytic-like effects of R(+)HA-966 at the level of the ventral tegmental area in rats
Morrow B, Elsworth J, Zito C, Roth R. Biochemical and behavioral anxiolytic-like effects of R(+)HA-966 at the level of the ventral tegmental area in rats. Psychopharmacology 1999, 143: 227-234. PMID: 10353424, DOI: 10.1007/s002130050941.Peer-Reviewed Original ResearchConceptsVentral tegmental areaHA-966Expression sessionsIntra-VTADopamine metabolismTegmental areaGlycine/NMDA receptor complexPrefrontal cortexMesoprefrontal dopamine neuronsAnxiolytic-like effectsAnxiolytic-like actionDopamine cell bodiesNMDA receptor complexWeak partial agonistMedial prefrontal cortexStress-induced activationCannula implantationDopamine neuronsControl ratsLocal injectionPartial agonistRatsCell bodiesPsychological stressorsStress-induced changes