2021
Expression of PON2 isoforms varies among brain regions in male and female African green monkeys
Jamwal S, Blackburn JK, Elsworth JD. Expression of PON2 isoforms varies among brain regions in male and female African green monkeys. Free Radical Biology And Medicine 2021, 178: 215-218. PMID: 34890766, PMCID: PMC8760629, DOI: 10.1016/j.freeradbiomed.2021.12.005.Peer-Reviewed Original ResearchConceptsAfrican green monkeysParkinson's diseaseBrain regionsParaoxonase 2Different brain regionsFemale monkeysGreen monkeysPON2 expressionOxidative stress-related neurodegenerative disordersFemale African green monkeysNeurodegenerative disordersMale African green monkeysOxidative stressPON2 protein expressionAnti-inflammatory propertiesExpression levelsSignificant differencesBrain tissue samplesDorsolateral prefrontal cortexNeuroprotective strategiesWestern blotting techniquesDopaminergic neuronsPON2 proteinPrimate brainProtective role
2001
Prenatal exposure to cocaine reduces the number and enhances reactivity of A10 dopaminergic neurons to environmental stress
Morrow B, Elsworth J, Roth R. Prenatal exposure to cocaine reduces the number and enhances reactivity of A10 dopaminergic neurons to environmental stress. Synapse 2001, 41: 337-344. PMID: 11494404, DOI: 10.1002/syn.1090.Peer-Reviewed Original ResearchConceptsA10 dopamine neuronsDopamine neuronsDopaminergic neuronsPrenatal exposurePrenatal saline controlsTyrosine hydroxylase immunoreactiveA10 dopaminergic neuronsCocaine-induced reductionRat dopaminergic neuronsCocaine-exposed ratsPoor cognitive performanceYoung adult offspringUnderlying biochemical changesDopaminergic functionA9 regionSaline controlsIntravenous modelPerinatal lossAdult offspringIntermittent footshockImmediate early genesCognitive deficitsNeuronal systemsBehavioral effectsCell groups
2000
Divergent effects of putative anxiolytics on stress‐induced Fos expression in the mesoprefrontal system of the rat
Morrow B, Elsworth J, Lee E, Roth R. Divergent effects of putative anxiolytics on stress‐induced Fos expression in the mesoprefrontal system of the rat. Synapse 2000, 36: 143-154. PMID: 10767061, DOI: 10.1002/(sici)1098-2396(200005)36:2<143::aid-syn7>3.0.co;2-h.Peer-Reviewed Original ResearchConceptsVentral tegmental areaFos-LITegmental areaMedial prefrontal cortexPutative anxiolyticsBenzodiazepine agonistsStress-induced Fos-like immunoreactivityPartial agonistStress-induced Fos expressionGlycine/NMDA receptorPrefrontal cortexMesoprefrontal dopamine neuronsPutative anxiolytic agentsTH-LI cellsSaline-treated ratsFos-like immunoreactivityAnxiolytic-like actionFos-LI nucleiWeak partial agonistStress-induced increaseFear-inducing behaviorFootshock paradigmAlpha2 agonistsStress-induced activationDopaminergic neurons
1999
Chapter 12 Fetal Grafts in Parkinson's Disease Primate Models
Sladek J, Collier T, Elsworth J, Roth R, Taylor J, Redmond D. Chapter 12 Fetal Grafts in Parkinson's Disease Primate Models. 1999, 321-364. DOI: 10.1016/b978-012705070-6/50013-5.Peer-Reviewed Original ResearchDisease patientsFetal tissue graftsParkinson's disease patientsProgressive neurological disorderEntire striatumParkinsonian symptomsFetal graftsClinical benefitDopaminergic neuronsSubstantia nigraClinical trialsNeurosurgical interventionPrimate modelParkinson's diseaseTissue graftDonor tissueNeurological disordersSource of cellsNeurodegenerative disordersFunctional changesProgressive lossHuman embryonic tissuesOptimal ageGraftSingle donor
1993
Fetal Dopamine Cell Survival after Transplantation Is Dramatically Improved at a Critical Donor Gestational Age in Nonhuman Primates
Sladek J, Elsworth J, Roth R, Evans L, Collier T, Cooper S, Taylor J, Redmond D. Fetal Dopamine Cell Survival after Transplantation Is Dramatically Improved at a Critical Donor Gestational Age in Nonhuman Primates. Experimental Neurology 1993, 122: 16-27. PMID: 8101820, DOI: 10.1006/exnr.1993.1103.Peer-Reviewed Original ResearchConceptsDopamine neuronsCaudate nucleusMesencephalic dopamine cell groupsTyrosine hydroxylase-positive neuronsTissue dopamine levelsUnfixed brain slicesDopamine cell groupsCell survivalDopamine cell survivalDopamine cell numberDays of gestationEarly gestation tissuesTime of implantationAfrican green monkeysVideo-based imagingGraft survivalMesencephalic tissueDonor graftsGestational ageNeural graftsNeurological disabilityDopaminergic neuronsGraft sizeDopamine contentSingle graft
1992
Unilateral Transplantation of Human Fetal Mesencephalic Tissue into the Caudate Nucleus of Patients with Parkinson's Disease
Spencer D, Robbins R, Naftolin F, Marek K, Vollmer T, Leranth C, Roth R, Price L, Gjedde A, Bunney B, Sass K, Elsworth J, Kier E, Makuch R, Hoffer P, Redmond D. Unilateral Transplantation of Human Fetal Mesencephalic Tissue into the Caudate Nucleus of Patients with Parkinson's Disease. New England Journal Of Medicine 1992, 327: 1541-1548. PMID: 1435880, DOI: 10.1056/nejm199211263272201.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAdultAntiparkinson AgentsCaudate NucleusCryopreservationCyclosporineDopamineFemaleFetal Tissue TransplantationHomovanillic AcidHumansMagnetic Resonance ImagingMaleMesencephalonMiddle AgedMotor ActivityParkinson DiseasePutamenStereotaxic TechniquesTomography, Emission-ComputedConceptsCase patientsParkinson's diseaseMesencephalic tissueCaudate nucleusHuman fetal ventral mesencephalic tissueFetal ventral mesencephalic tissueHuman fetal mesencephalic tissueContinued disease progressionFetal dopaminergic neuronsFetal mesencephalic tissueVentral mesencephalic tissueSevere Parkinson's diseaseOptimal drug therapySigns of parkinsonismMidbrain dopamine neuronsPositron emission tomographyMonths of evaluationAntiparkinsonian medicationUnilateral transplantationDrug holidayMore medicationsStriatonigral degenerationNeurologic functionDopaminergic neuronsDrug therapy
1988
Chapter 64 Fetal dopamine neural grafts: extended reversal of methylphenyltetrahydropyridine-induced parkinsonism in monkeys
Sladek J, Redmond D, Collier T, Blount J, Elsworth J, Taylor J, Roth R. Chapter 64 Fetal dopamine neural grafts: extended reversal of methylphenyltetrahydropyridine-induced parkinsonism in monkeys. Progress In Brain Research 1988, 78: 497-506. PMID: 3266802, DOI: 10.1016/s0079-6123(08)60323-4.Peer-Reviewed Original ResearchConceptsDopamine neuronsTherapeutic interventionsHuman parkinsonismHost brainFunctional recoveryDopaminergic neuronsSubstantia nigraCell graftsDopamine levelsFetal brainGraft siteTrophic factorsHuman neuronsAnatomical substrateParkinsonismCerebellar tissueControl transplantsNeuronsGraftBrain activityPhenotype characteristicBrainInterventionTransplantationTransplant
1987
Differential responsiveness to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in sub-regions of the primate substantia nigra and striatum
Elsworth J, Deutch A, Redmond D, Sladek J, Roth R. Differential responsiveness to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in sub-regions of the primate substantia nigra and striatum. Life Sciences 1987, 40: 193-202. PMID: 3491946, DOI: 10.1016/0024-3205(87)90359-6.Peer-Reviewed Original ResearchConceptsSubstantia nigraParkinsonian disabilityDA neuronsSymptomatic animalsMedial regionAsymptomatic animalsHVA/DA ratioLateral regionsDA concentrationPrimate substantia nigraDA histofluorescenceNigrostriatal pathwayTetrahydropyridine (MPTP) toxicityDopaminergic neuronsContralateral halfDA ratioDopaminergic cellsLipofuscin fluorescenceCell bodiesStriatumIndividual neuronsNeuronsDifferential responsivenessMarked lossDopamine
1986
Preferential vulnerability of A8 dopamine neurons in the primate to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Deutch A, Elsworth J, Goldstein M, Fuxe K, Redmond D, Sladek J, Roth R. Preferential vulnerability of A8 dopamine neurons in the primate to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Neuroscience Letters 1986, 68: 51-56. PMID: 3487756, DOI: 10.1016/0304-3940(86)90228-4.Peer-Reviewed Original ResearchConceptsA8 regionDA neuronsSubstantia nigraDopamine cell groupsDopaminergic neuronsDopamine neuronsImmunohistochemical examinationPreferential vulnerabilityHomovanillic acidBiochemical assessmentCell groupsMarked depletionNeuronsSame animalsSignificant decreaseMarked lossMPTPStriatumNigraVervet monkeysMidbrainTetrahydropyridine