1997
Dysregulation of Mesoprefrontal Dopamine Neurons Induced by Acute and Repeated Phencyclidine Administration in the Nonhuman Primate: Implications for Schizophrenia
Jentsch J, Elsworth J, Taylor J, Redmond D, Roth R. Dysregulation of Mesoprefrontal Dopamine Neurons Induced by Acute and Repeated Phencyclidine Administration in the Nonhuman Primate: Implications for Schizophrenia. Advances In Pharmacology 1997, 42: 810-814. PMID: 9328021, DOI: 10.1016/s1054-3589(08)60870-4.Peer-Reviewed Original ResearchConceptsPCP administrationAcute PCP administrationNegative symptomsDA systemMesoprefrontal dopamine neuronsSubcortical DA systemsBrains of patientsSchizophrenia-like symptomatologyDevelopment of neuropathologyDistinct behavioral effectsDAergic dysfunctionDA metabolismDAergic functionDopamine neuronsCognitive dysfunctionNovel agentsDeficits of schizophreniaFrontal cortexPsychotomimetic propertiesNeurobiological effectsDopamine systemPositive symptomsPhencyclidine administrationBehavioral effectsAdministration
1996
Sensitization to the locomotor activating effects of cocaine following cocaethylene-preexposure
Horger B, Taylor J, Elsworth J, Jatlow P, Roth R. Sensitization to the locomotor activating effects of cocaine following cocaethylene-preexposure. Brain Research 1996, 733: 133-137. PMID: 8891259, DOI: 10.1016/0006-8993(96)00783-4.Peer-Reviewed Original Research
1995
Selective Increase in Dopamine Utilization in the Shell Subdivision of the Nucleus Accumbens by the Benzodiazepine Inverse Agonist FG 7142
Horger B, Elsworth J, Roth R. Selective Increase in Dopamine Utilization in the Shell Subdivision of the Nucleus Accumbens by the Benzodiazepine Inverse Agonist FG 7142. Journal Of Neurochemistry 1995, 65: 770-774. PMID: 7616234, DOI: 10.1046/j.1471-4159.1995.65020770.x.Peer-Reviewed Original ResearchConceptsBenzodiazepine inverse agonist FG 7142Dopamine utilizationFG 7142Nucleus accumbensShell subdivisionWhole nucleus accumbensVivo microdialysis studyRats 30 minMedial prefrontal cortexMicrodialysis studyDopamine metabolismDopamine releaseDihydroxyphenylacetic acidAccumbensBrain regionsPrefrontal cortexSelective increaseMajor metaboliteTissue concentrationsPrevious reportsAdministration
1988
Reversal of Experimental Parkinsonism in African Green Monkeys Following Fetal Dopamine Neuron Transplantation
Collier T, Redmond D, Roth R, Elsworth J, Sladek J. Reversal of Experimental Parkinsonism in African Green Monkeys Following Fetal Dopamine Neuron Transplantation. 1988, 211-218. DOI: 10.1007/978-1-4613-0759-4_27.Peer-Reviewed Original ResearchChronic L-DOPA administrationL-DOPA administrationAfrican green monkeysNeuron transplantationExperimental parkinsonismMotor symptomsNigrostriatal systemBrain dopamineMotor abnormalitiesPreferred treatmentParkinson's diseaseL-DOPAGreen monkeysDiseaseProgressive debilitationNeurotransmitter dopamineAdministrationDopamineParkinsonismTransplantationSymptomsAbnormalitiesBrainSupplementation
1978
Deprenyl administration in man: A selective monoamine oxidase B inhibitor without the ‘cheese effect’
Elsworth J, Glover V, Reynolds G, Sandler M, Lees A, Phuapradit P, Shaw K, Stern G, Kumar P. Deprenyl administration in man: A selective monoamine oxidase B inhibitor without the ‘cheese effect’. Psychopharmacology 1978, 57: 33-38. PMID: 96466, DOI: 10.1007/bf00426954.Peer-Reviewed Original ResearchConceptsMonoamine oxidase B inhibitorsSelective monoamine oxidase B inhibitorNormal dietCheese effectB inhibitorHuman intestinal mucosaNormal human intestinal mucosaPressor responseOral tyraminePressor reactionDeprenyl administrationAdverse reactionsMonoamine oxidase AIntestinal mucosaOxidase AHuman plateletsPlatelet enzymeDeprenylComplete inhibitionVolunteersDietTyramineInhibitorsMucosaAdministration