Intraflagellar Transport Is Required for the Vectorial Movement of TRPV Channels in the Ciliary Membrane
Qin H, Burnette DT, Bae YK, Forscher P, Barr MM, Rosenbaum JL. Intraflagellar Transport Is Required for the Vectorial Movement of TRPV Channels in the Ciliary Membrane. Current Biology 2005, 15: 1695-1699. PMID: 16169494, DOI: 10.1016/j.cub.2005.08.047.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiological TransportCaenorhabditis elegansCaenorhabditis elegans ProteinsCell MembraneCiliaGreen Fluorescent ProteinsIon ChannelsMembrane ProteinsMicroscopy, FluorescenceNerve Tissue ProteinsNeurons, AfferentTransient Receptor Potential ChannelsTRPP Cation ChannelsTRPV Cation ChannelsConceptsCiliary membraneCaenorhabditis elegans sensory neuronsTime-lapse fluorescence microscopyIntraflagellar transport (IFT) machineryCiliary basal bodiesTransient receptor potential vanilloidMutant backgroundPKD-2Transport machineryIntraflagellar transportOSM-9Membrane proteinsProtein movementVectorial movementAxonemal componentsTRPV channelsBasal bodiesAxonemal microtubulesVectorial transportSensory transductionFluorescence microscopySensory cellsMembraneMotilityCilia