2011
EBI2 Guides Serial Movements of Activated B Cells and Ligand Activity Is Detectable in Lymphoid and Nonlymphoid Tissues
Kelly LM, Pereira JP, Yi T, Xu Y, Cyster JG. EBI2 Guides Serial Movements of Activated B Cells and Ligand Activity Is Detectable in Lymphoid and Nonlymphoid Tissues. The Journal Of Immunology 2011, 187: 3026-3032. PMID: 21844396, PMCID: PMC3169736, DOI: 10.4049/jimmunol.1101262.Peer-Reviewed Original ResearchConceptsActivated B cellsB cellsAb responsesNonlymphoid tissuesCCR7-dependent mannerSecondary lymphoid organsDependent Ab responsesB cell migrationLigand activityCCR7 downregulationLymphoid organsFollicular regionsEBI2Outer follicleT zoneCD40 engagementCell linesLipid ligandsLymphoidCell migrationGene 2CellsTissueSerial movementsEarly wave
2010
Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses
Pereira JP, Kelly LM, Cyster JG. Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses. International Immunology 2010, 22: 413-419. PMID: 20508253, PMCID: PMC2877811, DOI: 10.1093/intimm/dxq047.Peer-Reviewed Original ResearchConceptsHumoral immune responseB cellsGerminal centersPlasma cellsImmune responseHigh-affinity plasma cellsHelper T cellsMemory B cellsDistinct stromal cellsB cell positioningB cell migrationSeparate subcompartmentDependent antibodyLymphoid tissueT cellsStromal cellsCell egressT zoneOrphan receptorChemokinesEarly phaseReceptorsCellsRecent studiesTissue
2009
T-bet–dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow
Jenne CN, Enders A, Rivera R, Watson SR, Bankovich AJ, Pereira JP, Xu Y, Roots CM, Beilke JN, Banerjee A, Reiner SL, Miller SA, Weinmann AS, Goodnow CC, Lanier LL, Cyster JG, Chun J. T-bet–dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow. Journal Of Experimental Medicine 2009, 206: 2469-2481. PMID: 19808259, PMCID: PMC2768857, DOI: 10.1084/jem.20090525.Peer-Reviewed Original ResearchEBI2 mediates B cell segregation between the outer and centre follicle
Pereira JP, Kelly LM, Xu Y, Cyster JG. EBI2 mediates B cell segregation between the outer and centre follicle. Nature 2009, 460: 1122-1126. PMID: 19597478, PMCID: PMC2809436, DOI: 10.1038/nature08226.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB-LymphocytesChemokine CXCL13Gene Expression RegulationGerminal CenterLymphocyte ActivationMiceMice, Inbred C57BLReceptors, G-Protein-CoupledConceptsB cellsAntibody responseEpstein-Barr virus infectionOrphan G protein-coupled receptorOuter follicleB cell segregationNormal B cell proliferationDefective antibody responsesB cell positioningGerminal center B cellsActivated B cellsB cell proliferationG protein-coupled receptorsLymphoid folliclesFollicle centersT cellsVirus infectionInterfollicular regionsMice LackingEBI2FolliclesMolecular cuesReceptorsCellsCorrect positioning