2016
Effects of andrographolide on intrahepatic cholestasis induced by alpha-naphthylisothiocyanate in rats
Khamphaya T, Chansela P, Piyachaturawat P, Suksamrarn A, Nathanson MH, Weerachayaphorn J. Effects of andrographolide on intrahepatic cholestasis induced by alpha-naphthylisothiocyanate in rats. European Journal Of Pharmacology 2016, 789: 254-264. PMID: 27475677, PMCID: PMC10804355, DOI: 10.1016/j.ejphar.2016.07.032.Peer-Reviewed Original ResearchConceptsCholestatic liver diseaseLiver diseaseIntrahepatic cholestasisLiver injuryProtective effectHepatic stellate cell activationAcute intrahepatic cholestasisAlpha-smooth muscle actinCholestatic liver injuryBile duct proliferationSerum alanine aminotransferaseNF-κB expressionSingle intraperitoneal injectionEffects of andrographolidePromising therapeutic optionEffective therapeutic approachPotent protective propertiesNuclear factor kappaStellate cell activationANIT injectionDuct proliferationTherapeutic optionsHepatoprotective effectPeriductular fibrosisAlternative therapies
2013
Alleviative effect of andrographolide on alpha‐naphthylisothiocyanate‐induced cholestatic liver injury in rats
Khamphaya T, Piyachaturawat P, Weerachayaphorn J. Alleviative effect of andrographolide on alpha‐naphthylisothiocyanate‐induced cholestatic liver injury in rats. The FASEB Journal 2013, 27: 1161.2-1161.2. DOI: 10.1096/fasebj.27.1_supplement.1161.2.Peer-Reviewed Original ResearchLiver injuryMonocyte chemoattractant protein-1Severe liver inflammationCholestatic liver damageCholestatic liver injuryBile duct proliferationChemoattractant protein-1Tumor necrosis factorPotential therapeutic actionNF-kB signalingGamma-glutamyl transpeptidaseLiver inflammationSerum aminotransferasesLiver failureLiver diseaseDuct proliferationLiver damageHepatoprotective effectMajor active compoundNecrosis factorHepatic accumulationNF-kBAndrographolide pretreatmentANITBile acids