2024
Agent-based modeling of stress anisotropy driven nematic ordering in growing biofilms
Li C, Nijjer J, Feng L, Zhang Q, Yan J, Zhang S. Agent-based modeling of stress anisotropy driven nematic ordering in growing biofilms. Soft Matter 2024, 20: 3401-3410. PMID: 38563244, PMCID: PMC11041162, DOI: 10.1039/d3sm01535a.Peer-Reviewed Original ResearchConceptsStress anisotropyShear stressShear stress relaxationHigh shear stressLow shear stressHydrostatic stressStress relaxationBiomedical applicationsTime delayComplex multicellular patternsMicroscopy imagesSpatial organization of cellsThree-dimensionalCell orderingNematic orderOrganization of cellsMulticellular patternsSpatiotemporal correlationAgarose gelBacterial biofilmsStressBiofilmStress landscapeGrowth conditionsAnisotropy
2020
Nonuniform growth and surface friction determine bacterial biofilm morphology on soft substrates
Fei C, Mao S, Yan J, Alert R, Stone H, Bassler B, Wingreen N, Košmrlj A. Nonuniform growth and surface friction determine bacterial biofilm morphology on soft substrates. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 7622-7632. PMID: 32193350, PMCID: PMC7148565, DOI: 10.1073/pnas.1919607117.Peer-Reviewed Original ResearchMeSH KeywordsAgarAnisotropyBiofilmsBiomechanical PhenomenaFrictionStress, MechanicalSurface PropertiesVibrio choleraeConceptsBiofilm matrix productionBiofilm morphologyBacterial biofilmsAvailability of nutrientsDistinct spatiotemporal patternsImportant physiological consequencesAgar substrateMatrix productionMechanistic insightsPhysiological consequencesBiofilmsSoft substratesSimilar morphologyDiffusion of nutrientsPattern formation processNutrientsBasic mechanismsAgar concentrationEukaryotesMorphological patternsMorphogenesisFundamental determinantsOrganismsGrowthVibrio
2018
Bacterial Biofilm Material Properties Enable Removal and Transfer by Capillary Peeling
Yan J, Moreau A, Khodaparast S, Perazzo A, Feng J, Fei C, Mao S, Mukherjee S, Košmrlj A, Wingreen NS, Bassler BL, Stone HA. Bacterial Biofilm Material Properties Enable Removal and Transfer by Capillary Peeling. Advanced Materials 2018, 30: e1804153. PMID: 30368924, PMCID: PMC8865467, DOI: 10.1002/adma.201804153.Peer-Reviewed Original ResearchConceptsBiofilm removal strategiesMaterial propertiesBiofouling problemsInterfacial propertiesSurface foulingRheological characterizationIndustrial operationsMechanical protectionSurface analysisBiofilm-forming bacterial speciesMultiple surfacesBiofilm-dwelling cellsVibrio cholerae biofilmsSurface-attached communitiesSurfaceRemoval strategiesPropertiesFouling