2020
Nonuniform growth and surface friction determine bacterial biofilm morphology on soft substrates
Fei C, Mao S, Yan J, Alert R, Stone H, Bassler B, Wingreen N, Košmrlj A. Nonuniform growth and surface friction determine bacterial biofilm morphology on soft substrates. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 7622-7632. PMID: 32193350, PMCID: PMC7148565, DOI: 10.1073/pnas.1919607117.Peer-Reviewed Original ResearchConceptsBiofilm matrix productionBiofilm morphologyBacterial biofilmsAvailability of nutrientsDistinct spatiotemporal patternsImportant physiological consequencesAgar substrateMatrix productionMechanistic insightsPhysiological consequencesBiofilmsSoft substratesSimilar morphologyDiffusion of nutrientsPattern formation processNutrientsBasic mechanismsAgar concentrationEukaryotesMorphological patternsMorphogenesisFundamental determinantsOrganismsGrowthVibrio
2019
Mechanical instability and interfacial energy drive biofilm morphogenesis
Yan J, Fei C, Mao S, Moreau A, Wingreen NS, Košmrlj A, Stone HA, Bassler BL. Mechanical instability and interfacial energy drive biofilm morphogenesis. ELife 2019, 8: e43920. PMID: 30848725, PMCID: PMC6453567, DOI: 10.7554/elife.43920.Peer-Reviewed Original ResearchConceptsSurface-attached bacterial communityBiofilm morphogenesisMorphogenesis programHigher organismsBiofilm expansionDiversity of morphologiesBacterial communitiesBiofilm surface morphologyRegulatory componentsBiofilm formationBacterial biofilmsModel systemEssential constituentBiofilmsMorphogenesisMutagenesisQuantitative image analysisOrganismsDiversityVibrio