2015
Differentiation of Human Protein-Induced Pluripotent Stem Cells toward a Retinal Pigment Epithelial Cell Fate
Gong J, Fields MA, Moreira EF, Bowrey HE, Gooz M, Ablonczy Z, Del Priore LV. Differentiation of Human Protein-Induced Pluripotent Stem Cells toward a Retinal Pigment Epithelial Cell Fate. PLOS ONE 2015, 10: e0143272. PMID: 26606685, PMCID: PMC4659559, DOI: 10.1371/journal.pone.0143272.Peer-Reviewed Original ResearchChapter Twenty-Eight Retinoid Processing in Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Cultures
Fields MA, Bowrey HE, Gong J, Ablonczy Z, Del Priore LV. Chapter Twenty-Eight Retinoid Processing in Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Cultures. Progress In Nucleic Acid Research And Molecular Biology 2015, 134: 477-490. PMID: 26310172, PMCID: PMC8680204, DOI: 10.1016/bs.pmbts.2015.06.004.Peer-Reviewed Original ResearchConceptsRetinal pigment epitheliumRetinal degenerative diseasesAge-related macular degenerationDegenerative diseasesPluripotent stem cell (iPSC) technologyPromising clinical optionNative retinal pigment epitheliumRetinal degenerative disordersStem cell-derived retinal pigment epitheliumStem cell technologyVisual functionMacular degenerationPigment epitheliumRetinoid processingClinical optionDegenerative disordersClinical therapyCell therapyPluripotent stem cell-derived retinal pigment epitheliumVisual cycleRPE-specific proteinTherapyDiseaseStem cellsTrans retinolNitrite Modification of Extracellular Matrix Alters CD46 Expression and VEGF Release in Human Retinal Pigment EpitheliumNitrite-Modified ECM Alters CD46 and VEGF In Vitro
Fields MA, Cai H, Bowrey HE, Moreira EF, Gooz M, Kunchithapautham K, Gong J, Vought E, Del Priore LV. Nitrite Modification of Extracellular Matrix Alters CD46 Expression and VEGF Release in Human Retinal Pigment EpitheliumNitrite-Modified ECM Alters CD46 and VEGF In Vitro. Investigative Ophthalmology & Visual Science 2015, 56: 4231-4238. PMID: 26161984, PMCID: PMC4703405, DOI: 10.1167/iovs.15-16438.Peer-Reviewed Original Research
2008
Effects of extracellular matrix and neighboring cells on induction of human embryonic stem cells into retinal or retinal pigment epithelial progenitors
Gong J, Sagiv O, Cai H, Tsang SH, Del Priore LV. Effects of extracellular matrix and neighboring cells on induction of human embryonic stem cells into retinal or retinal pigment epithelial progenitors. Experimental Eye Research 2008, 86: 957-965. PMID: 18472095, PMCID: PMC4405535, DOI: 10.1016/j.exer.2008.03.014.Peer-Reviewed Original ResearchConceptsHuman embryonic stem cellsEmbryonic stem cellsNeural progenitorsNeural progenitor markersPA6 cellsStem cellsRPE markersProgenitor markersExtracellular matrixHuman Bruch's membrane explantsNeighboring cellsGene expression profilesNervous system developmentBruch's membrane explantsPA6 stromal cellsNew genesNeural retinaAdult neural retinaExpression profilesMicroarray analysisEpithelial progenitorsInduced expressionCell adhesionNeurite formationNeuronal phenotype