2016
Potential of Induced Pluripotent Stem Cells (iPSCs) for Treating Age-Related Macular Degeneration (AMD)
Fields M, Cai H, Gong J, Del Priore L. Potential of Induced Pluripotent Stem Cells (iPSCs) for Treating Age-Related Macular Degeneration (AMD). Cells 2016, 5: 44. PMID: 27941641, PMCID: PMC5187528, DOI: 10.3390/cells5040044.Peer-Reviewed Original ResearchInduced pluripotent stem cellsEmbryonic stem cellsAge-related macular degenerationPluripotent stem cellsCell replacement therapyDisease modelingIPSC disease modelingStem cellsReplacement therapyMacular degenerationRegenerative medicineRetinal pigment epithelium cellsStem cell biologyPigment epithelium cellsRetinal degenerative disordersUnlimited sourceDrug development platformClinical trialsDevelopment platformStargardt diseaseAnimal modelsRetinal degenerationAutologous sourceDegenerative disordersTherapeutic use
2008
Effects of extracellular matrix and neighboring cells on induction of human embryonic stem cells into retinal or retinal pigment epithelial progenitors
Gong J, Sagiv O, Cai H, Tsang SH, Del Priore LV. Effects of extracellular matrix and neighboring cells on induction of human embryonic stem cells into retinal or retinal pigment epithelial progenitors. Experimental Eye Research 2008, 86: 957-965. PMID: 18472095, PMCID: PMC4405535, DOI: 10.1016/j.exer.2008.03.014.Peer-Reviewed Original ResearchConceptsHuman embryonic stem cellsEmbryonic stem cellsNeural progenitorsNeural progenitor markersPA6 cellsStem cellsRPE markersProgenitor markersExtracellular matrixHuman Bruch's membrane explantsNeighboring cellsGene expression profilesNervous system developmentBruch's membrane explantsPA6 stromal cellsNew genesNeural retinaAdult neural retinaExpression profilesMicroarray analysisEpithelial progenitorsInduced expressionCell adhesionNeurite formationNeuronal phenotype