Hormone-sensitive lipase knockout mice have increased hepatic insulin sensitivity and are protected from short-term diet-induced insulin resistance in skeletal muscle and heart
Park SY, Kim HJ, Wang S, Higashimori T, Dong J, Kim YJ, Cline G, Li H, Prentki M, Shulman GI, Mitchell GA, Kim JK. Hormone-sensitive lipase knockout mice have increased hepatic insulin sensitivity and are protected from short-term diet-induced insulin resistance in skeletal muscle and heart. AJP Endocrinology And Metabolism 2005, 289: e30-e39. PMID: 15701680, DOI: 10.1152/ajpendo.00251.2004.Peer-Reviewed Original ResearchConceptsHSL-KO miceHormone-sensitive lipaseDiet-induced insulin resistanceHSL-deficient miceHigh-fat feedingInsulin resistanceSkeletal muscleGlucose metabolismInsulin actionTissue-specific insulin actionWhole-body fat massGlucose uptakeDiabetic heart failureDiet-induced obesityNormal chow dietBody fat massGroups of miceHyperinsulinemic-euglycemic clampType 2 diabetesFatty acyl-CoA levelsHepatic insulin actionHepatic insulin sensitivityWild-type miceLiver glucose metabolismCardiac glucose uptake