A Role for Mitochondrial Phosphoenolpyruvate Carboxykinase (PEPCK-M) in the Regulation of Hepatic Gluconeogenesis*
Stark R, Guebre-Egziabher F, Zhao X, Feriod C, Dong J, Alves TC, Ioja S, Pongratz RL, Bhanot S, Roden M, Cline GW, Shulman GI, Kibbey RG. A Role for Mitochondrial Phosphoenolpyruvate Carboxykinase (PEPCK-M) in the Regulation of Hepatic Gluconeogenesis*. Journal Of Biological Chemistry 2014, 289: 7257-7263. PMID: 24497630, PMCID: PMC3953244, DOI: 10.1074/jbc.c113.544759.Peer-Reviewed Original ResearchMeSH KeywordsAnimal FeedAnimalsBlood GlucoseFood DeprivationGene Expression Regulation, EnzymologicGene SilencingGluconeogenesisGlycerolGlycogenGuanosine TriphosphateHepatocytesHomeostasisInsulinIntracellular Signaling Peptides and ProteinsIsoenzymesLactic AcidLiverMaleMitochondriaOligonucleotides, AntisenseOxygenOxygen ConsumptionPhosphoenolpyruvate Carboxykinase (GTP)RatsRats, Sprague-DawleyConceptsGTP-dependent pathwayMitochondrial isoformMitochondrial phosphoenolpyruvate carboxykinaseSynthesis of phosphoenolpyruvateCytosolic isoformSubstrate preferenceMitochondrial substrates