2018
The I1 dynein-associated tether and tether head complex is a conserved regulator of ciliary motility
Fu G, Wang Q, Phan N, Urbanska P, Joachimiak E, Lin J, Wloga D, Nicastro D. The I1 dynein-associated tether and tether head complex is a conserved regulator of ciliary motility. Molecular Biology Of The Cell 2018, 29: mbc.e18-02-0142. PMID: 29514928, PMCID: PMC5921572, DOI: 10.1091/mbc.e18-02-0142.Peer-Reviewed Original ResearchConceptsI1 dyneinCiliary motilityAxonemal dynein motorsDynein motor domainMotor domainCiliary doublet microtubulesCK1 kinasesProper phosphorylationNormal ciliary motilityBiochemical approachesCryoelectron tomographyDynein motorsRegulatory mechanismsMotility regulatorMotile ciliaDoublet microtubulesRegulatorDyneinStable anchoringMotilityCiliary beatingComplexesHead complexMechanical feedbackImportant role
2012
The CSC connects three major axonemal complexes involved in dynein regulation
Heuser T, Dymek EE, Lin J, Smith EF, Nicastro D. The CSC connects three major axonemal complexes involved in dynein regulation. Molecular Biology Of The Cell 2012, 23: 3143-3155. PMID: 22740634, PMCID: PMC3418309, DOI: 10.1091/mbc.e12-05-0357.Peer-Reviewed Original ResearchConceptsNexin-dynein regulatory complexDynein regulationRadial spokesAxonemal complexCryo-electron tomographyWild-type motilityRegulatory complexFlagellar motilityDynein motorsChlamydomonas flagellaMotile ciliaStable assemblyFlagellaDifferent functionsRegulationRS1ComplexesMotilityStructural heterogeneityRS2Human healthImportant roleOrganellesHomologuesCSC