2017
Puberty is an important developmental period for the establishment of adipose tissue mass and metabolic homeostasis
Holtrup B, Church CD, Berry R, Colman L, Jeffery E, Bober J, Rodeheffer MS. Puberty is an important developmental period for the establishment of adipose tissue mass and metabolic homeostasis. Adipocyte 2017, 6: 224-233. PMID: 28792785, PMCID: PMC5638358, DOI: 10.1080/21623945.2017.1349042.Peer-Reviewed Original ResearchConceptsChildhood obesityMetabolic dysfunctionMetabolic homeostasisObesogenic stimuliExposure of miceHigh-fat dietAdipose tissue functionAdipose tissue massPostnatal day 18White adipose tissueType II diabetesCritical developmental periodAdipose massFat dietLeptin expressionAdipocyte sizeFat massDiabetic phenotypeObesityTissue massAdipose tissueBody weightDay 18II diabetesAdipose function
2009
Comparative Transduction Efficiency of AAV Vector Serotypes 1–6 in the Substantia Nigra and Striatum of the Primate Brain
Markakis EA, Vives KP, Bober J, Leichtle S, Leranth C, Beecham J, Elsworth JD, Roth RH, Samulski RJ, Redmond DE. Comparative Transduction Efficiency of AAV Vector Serotypes 1–6 in the Substantia Nigra and Striatum of the Primate Brain. Molecular Therapy 2009, 18: 588-593. PMID: 20010918, PMCID: PMC2839442, DOI: 10.1038/mt.2009.286.Peer-Reviewed Original ResearchConceptsSubstantia nigraPrimate brainCaudate nucleusSerotype 1Central nervous systemProtein-positive cellsAAV serotype 2Long-term transductionNigrostriatal systemClinical trialsPositive cellsNervous systemUnbiased stereologyVector injectionComparable titersNeural cellsBrainTransduction efficiencySerotype 2Vector transduction efficiencyTherapeutic transgenesViral vectorsNigraEnhanced green fluorescent protein (EGFP) reporter geneAAV vectors