2014
Low-Frequency NNRTI-Resistant HIV-1 Variants and Relationship to Mutational Load in Antiretroviral-Naïve Subjects
Gupta S, Lataillade M, Kyriakides TC, Chiarella J, St. John EP, Webb S, Moreno EA, Simen BB, Kozal MJ. Low-Frequency NNRTI-Resistant HIV-1 Variants and Relationship to Mutational Load in Antiretroviral-Naïve Subjects. Viruses 2014, 6: 3428-3437. PMID: 25256391, PMCID: PMC4189030, DOI: 10.3390/v6093428.Peer-Reviewed Original ResearchConceptsNNRTI resistance mutationsMajor NNRTI-resistance mutationsResistance mutationsAntiretroviral-naïve subjectsARV-naïve HIVMajor NNRTI mutationsNNRTI-resistant variantsTreatment-naïve HIVHIV-1 variantsNon-nucleoside reverseMutational loadNaïve HIVNNRTI mutationsNNRTI resistanceVariant frequencyTrue burdenTherapeutic failureTreatment outcomesTreatment responseAa positionsHIVViral variantsFurther evaluationResistant variantsDeep sequencing
2007
Natural Polymorphism of the HIV-1 Integrase Gene and Mutations associated with Integrase Inhibitor Resistance
Lataillade M, Chiarella J, Kozal MJ. Natural Polymorphism of the HIV-1 Integrase Gene and Mutations associated with Integrase Inhibitor Resistance. Antiviral Therapy 2007, 12: 563-570. PMID: 17668566, DOI: 10.1177/135965350701200411.Peer-Reviewed Original ResearchConceptsHIV-1 clade BHIV-1 integrase geneINI-naive patientsStrand transfer inhibitorsHIV-1 integrationGene polymorphismsINI resistanceExcellent virological responseClinical HIV-1Late-stage clinical developmentLos Alamos databaseIntegrase inhibitor resistanceNatural polymorphismsHigh-level resistanceI203MVirological responseClade BClinical trialsHIV-1Aa positionsE138KLate-stage developmentClinical developmentA128TDrug resistance