Severely impaired terminal erythroid differentiation as an independent prognostic marker in myelodysplastic syndromes
Ali AM, Huang Y, Pinheiro RF, Xue F, Hu J, Iverson N, Hoehn D, Coutinho D, Kayani J, Chernak B, Lane J, Hillyer C, Galili N, Jurcic J, Mohandas N, An X, Raza A. Severely impaired terminal erythroid differentiation as an independent prognostic marker in myelodysplastic syndromes. Blood Advances 2018, 2: 1393-1402. PMID: 29903708, PMCID: PMC6020814, DOI: 10.1182/bloodadvances.2018018440.Peer-Reviewed Original ResearchMeSH KeywordsBone MarrowCell DifferentiationErythrocytesErythropoiesisHumansMutationMyelodysplastic SyndromesPrognosisSerine-Arginine Splicing FactorsSurvival AnalysisConceptsIndependent prognostic markerMyelodysplastic syndromeOverall survivalPrognostic markerMultivariable Cox proportional hazards regression analysisCox proportional hazards regression analysisPowerful independent prognostic markerInternational Prognostic Scoring SystemProportional hazards regression analysisMyeloid/erythroid ratioTerminal erythroid differentiationIPSS-R categoryPrognostic scoring systemHazards regression analysisWorse overall survivalPoor overall survivalBone marrow samplesSurface expressionMost patientsProportion of cellsErythroid ratioMarrow samplesErythroid differentiationSRSF2 mutationsMDS samples