2020
VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours
Song E, Mao T, Dong H, Boisserand LSB, Antila S, Bosenberg M, Alitalo K, Thomas JL, Iwasaki A. VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours. Nature 2020, 577: 689-694. PMID: 31942068, PMCID: PMC7100608, DOI: 10.1038/s41586-019-1912-x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain NeoplasmsCD8-Positive T-LymphocytesCell Cycle CheckpointsCell Line, TumorCell MovementCentral Nervous SystemCross-PrimingFemaleGlioblastomaHEK293 CellsHumansImmunologic MemoryImmunologic SurveillanceLymph NodesLymphangiogenesisLymphatic VesselsMaleMelanomaMeningesMiceMice, Inbred C57BLProgrammed Cell Death 1 ReceptorVascular Endothelial Growth Factor CConceptsCD8 T cellsCentral nervous systemT cellsImmune responseBrain tumorsImmune surveillanceLymphatic drainageNervous systemAntigen-specific immune responsesDeep cervical lymph nodesCapacity of VEGFCervical lymph nodesCheckpoint blockade therapyMeningeal lymphatic systemVascular endothelial growth factor CNew therapeutic approachesUncontrolled tumor growthMeningeal lymphatic vasculatureBlockade therapyLymph nodesTherapeutic approachesMouse modelTumor growthMemory responsesTumors
2019
Endophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis
Genet G, Boyé K, Mathivet T, Ola R, Zhang F, Dubrac A, Li J, Genet N, Henrique Geraldo L, Benedetti L, Künzel S, Pibouin-Fragner L, Thomas JL, Eichmann A. Endophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis. Nature Communications 2019, 10: 2350. PMID: 31138815, PMCID: PMC6538628, DOI: 10.1038/s41467-019-10359-x.Peer-Reviewed Original ResearchMeSH KeywordsAcyltransferasesAnimalsCell MovementCell PolarityCell ProliferationCell SurvivalEndocytosisEndothelial CellsIntercellular Signaling Peptides and ProteinsMAP Kinase Signaling SystemMiceMice, KnockoutNeovascularization, PhysiologicNerve Tissue ProteinsP21-Activated KinasesReceptors, ImmunologicRetinal VesselsVascular Endothelial Growth Factor Receptor-2ConceptsEndophilin A2Endothelial cell migrationSprouting angiogenesisCell migrationFront-rear polarityBAR domain proteinsFront-rear polarizationClathrin-independent internalizationSpecific endocytic pathwaysVEGFR2 endocytosisEndocytic pathwayAngiogenesis defectsEffector PAKTip cellsSlit-RoboActivation of VEGFR2Downstream activationVEGFR2 internalizationCell behaviorPathological angiogenesisCritical mediatorEndocytosisPathological conditions
2011
Paracrine Pax6 activity regulates oligodendrocyte precursor cell migration in the chick embryonic neural tube
Di Lullo E, Haton C, Le Poupon C, Volovitch M, Joliot A, Thomas JL, Prochiantz A. Paracrine Pax6 activity regulates oligodendrocyte precursor cell migration in the chick embryonic neural tube. Development 2011, 138: 4991-5001. PMID: 22028031, DOI: 10.1242/dev.066282.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedCell DifferentiationCell MovementChick EmbryoExtracellular SpaceEye ProteinsHomeodomain ProteinsNerve Tissue ProteinsNeural TubeOligodendrogliaPaired Box Transcription FactorsParacrine CommunicationPAX6 Transcription FactorProtein TransportRepressor ProteinsStem CellsSubstrate SpecificityTissue DistributionConceptsPrecursor cell migrationPax6 proteinPax6 activityChick embryonic neural tubeNeural tubeCell migrationChick neural tubeOligodendrocyte precursor cell migrationEmbryonic neural tubeHomeoprotein transcription factorOPC migrationGene transfer experimentsEmbryonic polarityTranscription factorsIntercellular transferExtracellular expressionPhysiological importancePax6Visual cortex plasticityProteinFundamental rolePossible roleParacrine effectsExpressionPax6 antibodies
2008
Genetic tracing of subpopulation neurons in the prethalamus of mice (Mus musculus)
Delaunay D, Heydon K, Miguez A, Schwab M, Nave K, Thomas J, Spassky N, Martinez S, Zalc B. Genetic tracing of subpopulation neurons in the prethalamus of mice (Mus musculus). The Journal Of Comparative Neurology 2008, 512: 74-83. PMID: 18973275, DOI: 10.1002/cne.21904.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell MovementCell ShapeGenes, ReporterMiceMice, TransgenicNeuronsStem CellsThalamusConceptsVentral lateral geniculateCre/lox reporter systemGFP reporter miceGABAergic cellsGABAergic neuronsGlutamatergic neuronsLateral geniculateZona incertaHypothalamic nucleiSubthalamic nucleusReporter miceZona limitans intrathalamicaVentricular cellsIntergeniculate leafletNeuronsProgenitor cellsPosterior partGenetic tracingDiencephalonPool of progenitorsGenetic labelingPLP transcriptsMiceBasal plateCellsA novel role for anosmin‐1 in the adhesion and migration of oligodendrocyte precursors
Bribián A, Esteban P, Clemente D, Soussi‐Yanicostas N, Thomas J, Zalc B, de Castro F. A novel role for anosmin‐1 in the adhesion and migration of oligodendrocyte precursors. Developmental Neurobiology 2008, 68: 1503-1516. PMID: 18814310, DOI: 10.1002/dneu.20678.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAntibodiesCell AdhesionCell MovementCells, CulturedChemotactic FactorsCollagenCricetinaeCricetulusEmbryo, MammalianExtracellular Matrix ProteinsFibroblast Growth Factor 2GangliosidesGene Expression Regulation, DevelopmentalMiceNerve Tissue ProteinsOligodendrogliaReceptor, Fibroblast Growth Factor, Type 1RetinaRNA, MessengerStem CellsConceptsOptic nerveOligodendrocyte precursorsEntire optic nerveEmbryonic optic nerveRetinal ganglion cellsAnosmin-1Ganglion cellsPreoptic areaCell adhesion moleculeOPC migrationGrowth factorAdhesion moleculesFGF-2Novel roleGuidance cuesFGFR1Soluble formImpairsCellsECM moleculesNovel effectNerveBlockadeEmbryonic stagesAxons
2005
Oligodendrocyte development in the embryonic brain: the contribution of the plp lineage
Le Bras B, Chatzopoulou E, Heydon K, Martínez S, Ikenaka K, Prestoz L, Spassky N, Zalc B, Thomas JL. Oligodendrocyte development in the embryonic brain: the contribution of the plp lineage. The International Journal Of Developmental Biology 2005, 49: 209-220. PMID: 15906234, DOI: 10.1387/ijdb.041963bl.Peer-Reviewed Original Research
2004
The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system
Lu X, le Noble F, Yuan L, Jiang Q, de Lafarge B, Sugiyama D, Bréant C, Claes F, De Smet F, Thomas JL, Autiero M, Carmeliet P, Tessier-Lavigne M, Eichmann A. The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature 2004, 432: 179-186. PMID: 15510105, DOI: 10.1038/nature03080.Peer-Reviewed Original ResearchConceptsNetrin receptor UNC5BEndothelial tip cell filopodiaTip cell filopodiaReceptor UNC5BEndothelial tip cellsVascular systemNetrin-1aTip cellsEndothelial cellsProper wiringAxon guidanceCell filopodiaNetrin receptorsGuidance eventsFilopodial retractionMorphogenesisUNC5BVessel branchingAberrant extensionAnatomical similaritiesNetrin-1CellsZebrafishGenesGuidance function
2002
Directional Guidance of Oligodendroglial Migration by Class 3 Semaphorins and Netrin-1
Spassky N, de Castro F, Le Bras B, Heydon K, Quéraud-LeSaux F, Bloch-Gallego E, Chédotal A, Zalc B, Thomas J. Directional Guidance of Oligodendroglial Migration by Class 3 Semaphorins and Netrin-1. Journal Of Neuroscience 2002, 22: 5992-6004. PMID: 12122061, PMCID: PMC6757938, DOI: 10.1523/jneurosci.22-14-05992.2002.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Adhesion MoleculesCell DivisionCell LineCell LineageCell MovementChemotaxisCulture TechniquesDCC ReceptorGlycoproteinsHumansMembrane ProteinsMiceNerve Growth FactorsNerve Tissue ProteinsNetrin ReceptorsNetrin-1Neuropilin-1OligodendrogliaOptic NerveReceptors, Cell SurfaceSemaphorin-3AStem CellsTumor Suppressor ProteinsConceptsOligodendrocyte precursor cellsEmbryonic optic nerveMigration of OPCsOptic nerveNetrin-1Sema 3ANetrin-1 receptorWhite matter tractsSema 3FMyelin-forming cellsColorectal cancerClass 3 semaphorinsLocalization of cellsNerveChemotactic effectNeuropilin-1Multiple fociFunctional migrationPrecursor cellsNetrin familyOligodendroglial migrationSemaphorinsNeural tubeDual effectGuidance cues
2001
Monofocal origin of telencephalic oligodendrocytes in the anterior entopeduncular area of the chick embryo
Olivier C, Cobos I, Villegas E, Spassky N, Zalc B, Martinez S, Thomas J. Monofocal origin of telencephalic oligodendrocytes in the anterior entopeduncular area of the chick embryo. Development 2001, 128: 1757-1769. PMID: 11311157, DOI: 10.1242/dev.128.10.1757.Peer-Reviewed Original ResearchConceptsAnterior entopeduncular areaTelencephalic oligodendrocytesOligodendrocyte progenitor cellsCentral nervous systemMyelin-forming cellsRostrocaudal distributionCaudorostral axisVentricular originNervous systemOligodendroglial cellsChick brainOligodendrocytesOligodendrocyte precursorsOligodendrocyte progenitorsVentricular neuroepitheliumCaudal forebrainEntire telencephalonMigratory propertiesQuail-chick chimerasProgenitor cellsBrainChick embryosCellsOligodendrogenesis