2023
Connexin 43-mediated neurovascular interactions regulate neurogenesis in the adult brain subventricular zone
Genet N, Genet G, Chavkin N, Paila U, Fang J, Vasavada H, Goldberg J, Acharya B, Bhatt N, Baker K, McDonnell S, Huba M, Sankaranarayanan D, Ma G, Eichmann A, Thomas J, Ffrench-Constant C, Hirschi K. Connexin 43-mediated neurovascular interactions regulate neurogenesis in the adult brain subventricular zone. Cell Reports 2023, 42: 112371. PMID: 37043357, PMCID: PMC10564973, DOI: 10.1016/j.celrep.2023.112371.Peer-Reviewed Original ResearchConceptsSubventricular zoneEndothelial cellsNSC proliferationNSC quiescenceAdult brain subventricular zoneBlood-brain barrierBrain subventricular zoneStem cell therapyNeural stem cell nicheNeurovascular interactionsNeuroblast generationAdult brainSingle-cell RNA sequencingNeurodegenerative disordersChannel-independent mannerCell therapySVZ-NSCsConnexin 43Expression of genesERK activationNSC regulationNSC behaviorRNA sequencingCx43Proliferation
2020
Whole-Genome and RNA Sequencing Reveal Variation and Transcriptomic Coordination in the Developing Human Prefrontal Cortex
Werling DM, Pochareddy S, Choi J, An JY, Sheppard B, Peng M, Li Z, Dastmalchi C, Santpere G, Sousa AMM, Tebbenkamp ATN, Kaur N, Gulden FO, Breen MS, Liang L, Gilson MC, Zhao X, Dong S, Klei L, Cicek AE, Buxbaum JD, Adle-Biassette H, Thomas JL, Aldinger KA, O’Day D, Glass IA, Zaitlen NA, Talkowski ME, Roeder K, State MW, Devlin B, Sanders SJ, Sestan N. Whole-Genome and RNA Sequencing Reveal Variation and Transcriptomic Coordination in the Developing Human Prefrontal Cortex. Cell Reports 2020, 31: 107489. PMID: 32268104, PMCID: PMC7295160, DOI: 10.1016/j.celrep.2020.03.053.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceBrainComputational BiologyDatabases, GeneticExome SequencingGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyGenomicsHumansPhenotypePolymorphism, Single NucleotidePrefrontal CortexQuantitative Trait LociSequence Analysis, RNATranscriptomeWhole Genome SequencingConceptsExpression levelsGene expression levelsTranscriptomic coordinationDisorder lociNeuropsychiatric traitsSpecific genesRisk lociGene expressionGenomic variantsDevelopmental stagesCell typesGenesLociTissue RNACommon variantsPostnatal stagesUnique resourceSpecific variantsExpressionEQTLsVariantsGenomeHuman prefrontal cortexRNATraits
2019
Lymphatic system in central nervous system
Thomas JL, Jacob L, Boisserand L. Lymphatic system in central nervous system. Médecine/sciences 2019, 35: 55-61. PMID: 30672459, DOI: 10.1051/medsci/2018309.Peer-Reviewed Original ResearchConceptsCentral nervous systemCerebrospinal fluidImmune surveyNervous systemLymphatic vesselsLymphatic systemBrain interstitial fluidHuman CNS diseasesNew therapeutic targetsPeripheral lymphatic systemInterstitial fluid drainageCerebral drainageMeningeal lymphatic vasculatureInterstitial fluidCNS diseaseFluid drainageTherapeutic targetPerivascular spacesTissue drainageConsiderable metabolic activityVasculatureDrainageVesselsMetabolic activityLymphatic vasculature
2018
Orchestrating cortical brain development
Thomas JL. Orchestrating cortical brain development. Science 2018, 361: 754-755. PMID: 30139860, DOI: 10.1126/science.aau7155.Peer-Reviewed Original ResearchConceptsCentral nervous systemBrain developmentEndothelial cellsCentral nervous system morphologyCortical brain developmentNeuronal cell componentsProper brain developmentNervous system morphologyOwn vascular networkGlial cellsNervous systemBlood vesselsNeural tissueVasculatureVascular networkCellsCell componentsNeurons
2016
Isolation and Culture of Adult Zebrafish Brain-derived Neurospheres.
Lopez-Ramirez MA, Calvo CF, Ristori E, Thomas JL, Nicoli S. Isolation and Culture of Adult Zebrafish Brain-derived Neurospheres. Journal Of Visualized Experiments 2016, 53617. PMID: 26967835, PMCID: PMC4828210, DOI: 10.3791/53617.Peer-Reviewed Original ResearchConceptsAdult zebrafish brainStem/progenitor cellsZebrafish brainMolecular mechanismsRelevant model organismZebrafish adult brainProgenitor cellsSingle-cell dissociationSpecific signaling pathwaysAdult stem/progenitor cellsStem/progenitor cell proliferationNeural stem/progenitor cell proliferationProgenitor cell proliferationNeural stem/progenitor cellsModel organismsGene expressionCell dissociationSignaling pathwaysMultipotent neural stem/progenitor cellsNeurosphere assayAdult neurogenesisCell proliferationZebrafishBrain regenerationAdult brain
2013
Ascl1/Mash1 Promotes Brain Oligodendrogenesis during Myelination and Remyelination
Nakatani H, Martin E, Hassani H, Clavairoly A, Maire CL, Viadieu A, Kerninon C, Delmasure A, Frah M, Weber M, Nakafuku M, Zalc B, Thomas JL, Guillemot F, Nait-Oumesmar B, Parras C. Ascl1/Mash1 Promotes Brain Oligodendrogenesis during Myelination and Remyelination. Journal Of Neuroscience 2013, 33: 9752-9768. PMID: 23739972, PMCID: PMC3892435, DOI: 10.1523/jneurosci.0805-13.2013.Peer-Reviewed Original ResearchConceptsOligodendrocyte precursor cellsNeonatal periodCortical oligodendrocyte precursor cellsOligodendrocyte developmentCortical subventricular zoneSubventricular zone progenitorsMultiple sclerosis lesionsMyelin-forming cellsPostnatal cortexRemyelination processFocal demyelinationCorpus callosumSubventricular zoneOPC differentiationPostnatal brainMouse modelAscl1 functionOligodendrogenesisOPC developmentSclerosis lesionsASCL1 expressionCortical progenitorsRemyelinationProneural transcription factorsOligodendrocytes
2012
Molecular Parallels between Neural and Vascular Development
Eichmann A, Thomas JL. Molecular Parallels between Neural and Vascular Development. Cold Spring Harbor Perspectives In Medicine 2012, 3: a006551. PMID: 23024177, PMCID: PMC3530036, DOI: 10.1101/cshperspect.a006551.Peer-Reviewed Original ResearchConceptsCentral nervous systemAdult neurogenic nichesMolecular parallelsNeural stem cellsCardiac outputMolecular mechanismsBlood vesselsNeurovascular interactionsVascular developmentHuman diseasesStem cellsCNS blood vesselsHuman central nervous systemBlood-brain barrierVascular endothelial growth factorNeurogenic nicheCell populationsEndothelial growth factorGrowth factorEndothelial cellsBlood glucoseNervous systemImportant roleCellsUnique population
2010
Nitric Oxide Plays a Key Role in Myelination in the Developing Brain
Olivier P, Loron G, Fontaine R, Pansiot J, Dalous J, Thi H, Charriaut-Marlangue C, Thomas J, Mercier J, Gressens P, Baud O. Nitric Oxide Plays a Key Role in Myelination in the Developing Brain. Journal Of Neuropathology & Experimental Neurology 2010, 69: 828-837. PMID: 20613635, DOI: 10.1097/nen.0b013e3181ea5203.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, InhalationAge FactorsAnimalsAnimals, NewbornAntigensBehavioral SymptomsBrainCell ProliferationCentral Nervous SystemDose-Response Relationship, DrugEnzyme InhibitorsExploratory BehaviorFemaleFree Radical ScavengersGene Expression Regulation, DevelopmentalIn Situ Nick-End LabelingKi-67 AntigenMaleMiceMice, Inbred C57BLMyelin Basic ProteinMyelin Proteolipid ProteinNerve Fibers, MyelinatedNerve Tissue ProteinsNeuronsNeuropsychological TestsNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide Synthase Type IIO AntigensOligodendrogliaProteoglycansRatsRats, Sprague-DawleySpace PerceptionSpatial BehaviorStatistics, NonparametricConceptsEndogenous NONitric oxide synthase inhibitor N-nitro-L-arginine methyl esterN-nitro-L-arginine methyl esterL-NAME-treated animalsNitric oxidePerinatal brain damageSubsequent behavioral deficitsCentral nervous system myelinationNeonatal exposureC57BL/6 miceNeonatal periodBrain damagePromising therapyBehavioral deficitsMouse pupsImmature oligodendrocytesPotential new avenuesWhite matterLow dosesProliferative effectMyelination defectsMyelinationTransient increaseINODeleterious effects
2006
VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain
Le Bras B, Barallobre MJ, Homman-Ludiye J, Ny A, Wyns S, Tammela T, Haiko P, Karkkainen MJ, Yuan L, Muriel MP, Chatzopoulou E, Bréant C, Zalc B, Carmeliet P, Alitalo K, Eichmann A, Thomas JL. VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain. Nature Neuroscience 2006, 9: 340-348. PMID: 16462734, DOI: 10.1038/nn1646.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCell DifferentiationCells, CulturedEvolution, MolecularIntermediate Filament ProteinsLarvaLateral VentriclesMiceMice, KnockoutMice, TransgenicNerve Growth FactorsNerve Tissue ProteinsNestinNeuronsOligodendrogliaOptic NerveRatsRats, WistarStem CellsVascular Endothelial Growth Factor CVascular Endothelial Growth Factor Receptor-3Xenopus laevisConceptsNeural progenitor cellsReceptor VEGFR-3Mouse embryosNeural progenitorsVEGFR-3Progenitor cellsVertebrate embryonic brainBlood vessel defectsOligodendrocyte precursor cellsXenopus laevisAction of VEGFEmbryonic brainVascular endothelial growth factor CVEGF-C knockdownNeural cellsPrecursor cellsVessel defectsFactor CEmbryosGrowth factorProgenitorsCellsProliferation of OPCsVascular systemLymphatic vessels
2005
Oligodendrocyte development in the embryonic brain: the contribution of the plp lineage
Le Bras B, Chatzopoulou E, Heydon K, Martínez S, Ikenaka K, Prestoz L, Spassky N, Zalc B, Thomas JL. Oligodendrocyte development in the embryonic brain: the contribution of the plp lineage. The International Journal Of Developmental Biology 2005, 49: 209-220. PMID: 15906234, DOI: 10.1387/ijdb.041963bl.Peer-Reviewed Original Research
2001
The Early Steps of Oligodendrogenesis: Insights from the Study of the plp Lineage in the Brain of Chicks and Rodents
Spassky N, Olivier C, Cobos I, LeBras B, Goujet-Zalc C, Martínez S, Zalc B, Thomas J. The Early Steps of Oligodendrogenesis: Insights from the Study of the plp Lineage in the Brain of Chicks and Rodents. Developmental Neuroscience 2001, 23: 318-326. PMID: 11756747, DOI: 10.1159/000048715.Peer-Reviewed Original ResearchConceptsOligodendroglial genesBrain of chicksCentral nervous systemMyelin-forming cellsSpinal cordPrimitive progenitor cellsNervous systemRodent brainOligodendroglial markersOligodendrocyte lineageEmbryonic brainProgenitor cellsBrainOligodendrogenesisCell lineagesProgenitor stageCellsChicksCordExpressionEarly stepsOligodendrocytes
2000
Spatiotemporal development of oligodendrocytes in the embryonic brain
Thomas J, Spassky N, Villegas E, Olivier C, Cobos I, Goujet‐Zalc C, Martínez S, Zalc B. Spatiotemporal development of oligodendrocytes in the embryonic brain. Journal Of Neuroscience Research 2000, 59: 471-476. PMID: 10679785, DOI: 10.1002/(sici)1097-4547(20000215)59:4<471::aid-jnr1>3.0.co;2-3.Peer-Reviewed Original ResearchConceptsCentral nervous systemOligodendrocyte precursor cellsPrecursor cellsNeural tubeSite of originSubventricular zoneNervous systemVentricular layerOligodendrocyte precursorsFirst neuronsOligodendrocyte progenitorsOligodendrocytesEmbryonic brainRostrocaudal axisLast cell typeQuail-chick chimerasProgenitor cellsRecent dataBrainCell typesMosaic populationProgenitor stageCellsNeurons
1999
Single or multiple oligodendroglial lineages: A controversy
Spassky N, Olivier C, Perez‐Villegas E, Goujet‐Zalc C, Martinez S, Thomas J, Zalc B. Single or multiple oligodendroglial lineages: A controversy. Glia 1999, 29: 143-148. PMID: 10625332, DOI: 10.1002/(sici)1098-1136(20000115)29:2<143::aid-glia7>3.0.co;2-d.Peer-Reviewed Original ResearchEarly Specification of Oligodendrocytes in the Chick Embryonic Brain
Villegas E, Olivier C, Spassky N, Poncet C, Cochard P, Zalc B, Thomas J, Martínez S. Early Specification of Oligodendrocytes in the Chick Embryonic Brain. Developmental Biology 1999, 216: 98-113. PMID: 10588866, DOI: 10.1006/dbio.1999.9438.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCell DifferentiationCells, CulturedChick EmbryoGene Expression Regulation, DevelopmentalImmunohistochemistryIn Situ HybridizationMyelin Proteolipid ProteinOligodendrogliaReceptor, Platelet-Derived Growth Factor alphaReverse Transcriptase Polymerase Chain ReactionRNA, Messenger
1996
Myelin/oligodendrocyte glycoprotein (MOG) expression is associated with myelin deposition
Solly S, Thomas J, Monge M, Demerens C, Lubetzki C, Gardinier M, Matthieu J, Zalc B. Myelin/oligodendrocyte glycoprotein (MOG) expression is associated with myelin deposition. Glia 1996, 18: 39-48. PMID: 8891690, DOI: 10.1002/(sici)1098-1136(199609)18:1<39::aid-glia4>3.0.co;2-z.Peer-Reviewed Original Research