2010
Nitric Oxide Plays a Key Role in Myelination in the Developing Brain
Olivier P, Loron G, Fontaine R, Pansiot J, Dalous J, Thi H, Charriaut-Marlangue C, Thomas J, Mercier J, Gressens P, Baud O. Nitric Oxide Plays a Key Role in Myelination in the Developing Brain. Journal Of Neuropathology & Experimental Neurology 2010, 69: 828-837. PMID: 20613635, DOI: 10.1097/nen.0b013e3181ea5203.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, InhalationAge FactorsAnimalsAnimals, NewbornAntigensBehavioral SymptomsBrainCell ProliferationCentral Nervous SystemDose-Response Relationship, DrugEnzyme InhibitorsExploratory BehaviorFemaleFree Radical ScavengersGene Expression Regulation, DevelopmentalIn Situ Nick-End LabelingKi-67 AntigenMaleMiceMice, Inbred C57BLMyelin Basic ProteinMyelin Proteolipid ProteinNerve Fibers, MyelinatedNerve Tissue ProteinsNeuronsNeuropsychological TestsNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide Synthase Type IIO AntigensOligodendrogliaProteoglycansRatsRats, Sprague-DawleySpace PerceptionSpatial BehaviorStatistics, NonparametricConceptsEndogenous NONitric oxide synthase inhibitor N-nitro-L-arginine methyl esterN-nitro-L-arginine methyl esterL-NAME-treated animalsNitric oxidePerinatal brain damageSubsequent behavioral deficitsCentral nervous system myelinationNeonatal exposureC57BL/6 miceNeonatal periodBrain damagePromising therapyBehavioral deficitsMouse pupsImmature oligodendrocytesPotential new avenuesWhite matterLow dosesProliferative effectMyelination defectsMyelinationTransient increaseINODeleterious effects
2001
Sonic hedgehog-dependent emergence of oligodendrocytes in the telencephalon: evidence for a source of oligodendrocytes in the olfactory bulb that is independent of PDGFRalpha signaling.
Spassky N, Heydon K, Mangatal A, Jankovski A, Olivier C, Queraud-Lesaux F, Goujet-Zalc C, Thomas J, Zalc B. Sonic hedgehog-dependent emergence of oligodendrocytes in the telencephalon: evidence for a source of oligodendrocytes in the olfactory bulb that is independent of PDGFRalpha signaling. Development 2001, 128: 4993-5004. PMID: 11748136, DOI: 10.1242/dev.128.24.4993.Peer-Reviewed Original ResearchConceptsSpinal cordPlatelet-derived growth factor receptorOlfactory bulbOligodendrocyte progenitorsInduction of oligodendrocytesSource of oligodendrocytesAnterior entopeduncular areaMedial ganglionic eminenceExpression of PLPGrowth factor receptorRostral palliumTelencephalic oligodendrocytesGanglionic eminenceVentricular focusOligodendroglial lineageCordRostral telencephalonOligodendrocytesOligodendrocyte lineageFactor receptorVentricular progenitorsTelencephalonMouse telencephalonSonic hedgehogMolecular mechanismsThe Early Steps of Oligodendrogenesis: Insights from the Study of the plp Lineage in the Brain of Chicks and Rodents
Spassky N, Olivier C, Cobos I, LeBras B, Goujet-Zalc C, Martínez S, Zalc B, Thomas J. The Early Steps of Oligodendrogenesis: Insights from the Study of the plp Lineage in the Brain of Chicks and Rodents. Developmental Neuroscience 2001, 23: 318-326. PMID: 11756747, DOI: 10.1159/000048715.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomarkersBrainCell DifferentiationCell LineageChick EmbryoHedgehog ProteinsHomeodomain ProteinsMiceMyelin Proteolipid ProteinNeuronsOligodendrogliaStem CellsTrans-ActivatorsConceptsOligodendroglial genesBrain of chicksCentral nervous systemMyelin-forming cellsSpinal cordPrimitive progenitor cellsNervous systemRodent brainOligodendroglial markersOligodendrocyte lineageEmbryonic brainProgenitor cellsBrainOligodendrogenesisCell lineagesProgenitor stageCellsChicksCordExpressionEarly stepsOligodendrocytes
1999
Single or multiple oligodendroglial lineages: A controversy
Spassky N, Olivier C, Perez‐Villegas E, Goujet‐Zalc C, Martinez S, Thomas J, Zalc B. Single or multiple oligodendroglial lineages: A controversy. Glia 1999, 29: 143-148. PMID: 10625332, DOI: 10.1002/(sici)1098-1136(20000115)29:2<143::aid-glia7>3.0.co;2-d.Peer-Reviewed Original ResearchEarly Specification of Oligodendrocytes in the Chick Embryonic Brain
Villegas E, Olivier C, Spassky N, Poncet C, Cochard P, Zalc B, Thomas J, Martínez S. Early Specification of Oligodendrocytes in the Chick Embryonic Brain. Developmental Biology 1999, 216: 98-113. PMID: 10588866, DOI: 10.1006/dbio.1999.9438.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCell DifferentiationCells, CulturedChick EmbryoGene Expression Regulation, DevelopmentalImmunohistochemistryIn Situ HybridizationMyelin Proteolipid ProteinOligodendrogliaReceptor, Platelet-Derived Growth Factor alphaReverse Transcriptase Polymerase Chain ReactionRNA, Messenger
1997
In situ expression of PLP/DM‐20, MBP, and CNP during embryonic and postnatal development of the jimpy mutant and of transgenic mice overexpressing PLP
Peyron F, Timsit S, Thomas J, Kagawa T, Ikenaka K, Zalc B. In situ expression of PLP/DM‐20, MBP, and CNP during embryonic and postnatal development of the jimpy mutant and of transgenic mice overexpressing PLP. Journal Of Neuroscience Research 1997, 50: 190-201. PMID: 9373029, DOI: 10.1002/(sici)1097-4547(19971015)50:2<190::aid-jnr8>3.0.co;2-a.Peer-Reviewed Original ResearchConceptsPLP/DMCyclic nucleotide phosphodiesteraseDM-20PLP geneMyelin basic proteinDM-20 mRNAPattern of expressionEmbryonic developmentLevel of expressionJimpy mutantPeripheral nervous systemTransgenic micePrecursors of oligodendrocytesSpatiotemporal expressionDistinct poolsNeural tubeCentral nervous system