2017
Development and plasticity of meningeal lymphatic vessels
Antila S, Karaman S, Nurmi H, Airavaara M, Voutilainen MH, Mathivet T, Chilov D, Li Z, Koppinen T, Park JH, Fang S, Aspelund A, Saarma M, Eichmann A, Thomas JL, Alitalo K. Development and plasticity of meningeal lymphatic vessels. Journal Of Experimental Medicine 2017, 214: 3645-3667. PMID: 29141865, PMCID: PMC5716035, DOI: 10.1084/jem.20170391.Peer-Reviewed Original ResearchAnimalsAnimals, NewbornBiological TransportCerebrospinal FluidDependovirusGene DeletionHumansIndolesInjections, IntraventricularLymph NodesLymphangiogenesisLymphatic VesselsMaleMeningesMice, Inbred C57BLMicrospheresMyocytes, Smooth MuscleProtein Kinase InhibitorsPyrrolesSignal TransductionSpinal CordSunitinibVascular Endothelial Growth Factor CVascular Endothelial Growth Factor DVascular Endothelial Growth Factor Receptor-3
2015
Targeting NCK-Mediated Endothelial Cell Front-Rear Polarity Inhibits Neovascularization
Dubrac A, Genet G, Ola R, Zhang F, Pibouin-Fragner L, Han J, Zhang J, Thomas JL, Chedotal A, Schwartz MA, Eichmann A. Targeting NCK-Mediated Endothelial Cell Front-Rear Polarity Inhibits Neovascularization. Circulation 2015, 133: 409-421. PMID: 26659946, PMCID: PMC4729599, DOI: 10.1161/circulationaha.115.017537.Peer-Reviewed Original ResearchConceptsFront-rear polaritySprouting angiogenesisSignal integration mechanismImportant drug targetsNck adaptorsCytoskeletal dynamicsEndothelial cell migrationEmbryonic developmentAngiogenesis defectsPAK2 activationVessel sproutsNumber of diseasesBlood vessel growthDrug targetsCell migrationPostnatal retinaAngiogenic growthNckNck1AdaptorVessel growthKey processesEndothelial cellsPathological ocular neovascularizationInhibits neovascularization