2017
The Xenopus tadpole: An in vivo model to screen drugs favoring remyelination
Mannioui A, Vauzanges Q, Fini JB, Henriet E, Sekizar S, Azoyan L, Thomas JL, Du Pasquier D, Giovannangeli C, Demeneix B, Lubetzki C, Zalc B. The Xenopus tadpole: An in vivo model to screen drugs favoring remyelination. Multiple Sclerosis Journal 2017, 24: 1421-1432. PMID: 28752787, DOI: 10.1177/1352458517721355.Peer-Reviewed Original ResearchConceptsSphingosine-1-phosphate receptor 5Receptor 5Sphingosine-1-phosphate receptor 1Efficacy of siponimodNumber of oligodendrocytesSpontaneous remyelinationMultiple sclerosisOptic nervePromyelinating effectE. coli nitroreductaseRemyelinationDual agonistsVivo modelReceptor 1SiponimodConditional ablationOligodendrocytesXenopus tadpolesVivo screeningCRISPR/Cas9 gene editingVivoCas9 gene editingDemyelinationSclerosisGreen fluorescent protein reporter
2007
Semaphorin 3A and 3F: key players in myelin repair in multiple sclerosis?
Williams A, Piaton G, Aigrot MS, Belhadi A, Théaudin M, Petermann F, Thomas JL, Zalc B, Lubetzki C. Semaphorin 3A and 3F: key players in myelin repair in multiple sclerosis? Brain 2007, 130: 2554-2565. PMID: 17855378, DOI: 10.1093/brain/awm202.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnimalsApoptosisCerebral CortexDisease Models, AnimalFemaleHumansIntracellular Signaling Peptides and ProteinsMaleMembrane ProteinsMiddle AgedMotor CortexMultiple SclerosisMyelin SheathNerve RegenerationNerve Tissue ProteinsNeurogliaNeuronsRatsRats, WistarRNA, MessengerSemaphorin-3ASignal TransductionUp-RegulationConceptsMultiple sclerosisSemaphorin 3AAbility of plaqueActive demyelinating lesionsNeuronal cell bodiesFailure of repairCentral nervous systemOligodendrocyte precursor cellsOligodendrocyte precursor cell migrationPrecursor cell migrationChronic plaquesDemyelinating lesionsDemyelinated plaquesMyelin repairDemyelinated axonsMS tissueNervous systemCell bodiesExperimental modelPlaquesLesionsPrecursor cellsSclerosisOligodendroglial migrationCell migration