2020
Three-Dimensional Imaging of the Vertebral Lymphatic Vasculature and Drainage using iDISCO+ and Light Sheet Fluorescence Microscopy.
Jacob L, Brito J, Thomas JL. Three-Dimensional Imaging of the Vertebral Lymphatic Vasculature and Drainage using iDISCO+ and Light Sheet Fluorescence Microscopy. Journal Of Visualized Experiments 2020 PMID: 32510513, DOI: 10.3791/61099.Peer-Reviewed Original ResearchConceptsLight sheet fluorescence microscopySheet fluorescence microscopyLymphatic vasculatureFluorescence microscopyCentral nervous systemLymphatic vesselsBiologyLymphatic systemLymphatic networkJoint biologyWhole-mount preparationsUnprecedented opportunityImmune surveillanceNervous systemImmune cellsTissueMount preparationsVertebral columnCNS tissueCellsMagnaMacromolecules
2019
Lymphatic system in central nervous system
Thomas JL, Jacob L, Boisserand L. Lymphatic system in central nervous system. Médecine/sciences 2019, 35: 55-61. PMID: 30672459, DOI: 10.1051/medsci/2018309.Peer-Reviewed Original ResearchConceptsCentral nervous systemCerebrospinal fluidImmune surveyNervous systemLymphatic vesselsLymphatic systemBrain interstitial fluidHuman CNS diseasesNew therapeutic targetsPeripheral lymphatic systemInterstitial fluid drainageCerebral drainageMeningeal lymphatic vasculatureInterstitial fluidCNS diseaseFluid drainageTherapeutic targetPerivascular spacesTissue drainageConsiderable metabolic activityVasculatureDrainageVesselsMetabolic activityLymphatic vasculature