RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao.
Traver S, Bidot C, Spassky N, Baltauss T, De Tand M, Thomas J, Zalc B, Janoueix-Lerosey I, Gunzburg J. RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao. Biochemical Journal 2000, 350 Pt 1: 19-29. PMID: 10926822, PMCID: PMC1221220, DOI: 10.1042/0264-6021:3500019.Peer-Reviewed Original ResearchConceptsGTPase activityRap effectorRGS proteinsRas/RapTwo-hybrid systemHeterotrimeric G proteinsRaf-1 kinaseG protein-coupled receptorsSitu hybridization experimentsRap proteinsGTPase Rap2Galpha subunitsHeterotrimeric proteinDeletion analysisDomain sharesRGS14Hybridization experimentsRap2B-RafAlpha subunitG proteinsProteinSitu hybridization studiesCertain cellsHybridization studies