2024
Acute Effects of Growth Hormone on the Cellular Immunologic Landscape in Pediatric Patients
Gujral J, Kidd B, Becker C, Golden E, Lee H, Kim-Schulze S, Yau M, Dudley J, Rapaport R. Acute Effects of Growth Hormone on the Cellular Immunologic Landscape in Pediatric Patients. Cureus 2024, 16: e57383. PMID: 38566781, PMCID: PMC10984134, DOI: 10.7759/cureus.57383.Peer-Reviewed Original ResearchTime-of-flight mass cytometryComplete blood countGrowth hormoneImmune systemDendritic cellsPediatric patientsAcute effectsAcute effects of growth hormoneMonocyte countProspective study of pediatric patientsStudy of pediatric patientsMass cytometryEffects of growth hormoneGH stimulation testsComplete blood count analysisAbsolute lymphocyte countWhite blood cell countAbsolute neutrophil countAbsolute monocyte countAbsolute eosinophil countTertiary care centerBlood cell countTotal white blood cell countGH statusGH response
2022
Growth hormone and omic systems immunology: the prominent role of interferon signaling
Lili L, Gujral J, Golden E, Yau M, Becker C, Kidd B, Dudley J, Rapaport R. Growth hormone and omic systems immunology: the prominent role of interferon signaling. Current Trends In Endocrinology 2022, 13 DOI: 10.31300/ctendo.13.2022.59-76.Peer-Reviewed Original ResearchNavigating barriers to affording and obtaining insulin and diabetes supplies
Wilcox A, Lipska K, Weinzimer S, Gujral J, Arakaki A, Kerandi L, Nally L. Navigating barriers to affording and obtaining insulin and diabetes supplies. Journal Of Diabetes 2022, 15: 71-75. PMID: 36562281, PMCID: PMC9870729, DOI: 10.1111/1753-0407.13344.Peer-Reviewed Original ResearchAn update on the diagnosis and treatment of adrenoleukodystrophy
Gujral J, Sethuram S. An update on the diagnosis and treatment of adrenoleukodystrophy. Current Opinion In Endocrinology Diabetes And Obesity 2022, 30: 44-51. PMID: 36373727, DOI: 10.1097/med.0000000000000782.Peer-Reviewed Original ResearchConceptsHematopoietic stem cell transplantTreatment optionsOnly successful treatment optionManagement of patientsStem cell transplantRecommended Uniform Screening PanelSuccessful treatment optionPotential treatment optionUniform Screening PanelTreatment of adrenoleukodystrophyAdrenal insufficiencyCell transplantCerebral adrenoleukodystrophyConsensus guidelinesNeurological changesNovel therapiesEarly diagnosisAnimal modelsAmerican AcademyAdrenoleukodystrophyTherapeutic agentsScreening panelDiagnosisTherapyDiseasePediatric diabetes update
Gujral J, Rapaport R. Pediatric diabetes update. Journal Of Diabetes 2022, 14: 568-570. PMID: 36114692, PMCID: PMC9512771, DOI: 10.1111/1753-0407.13317.Peer-Reviewed Original ResearchCommentary on CDC data showing an increased risk for pediatric diabetes with COVID‐19 infection
Gujral J, Tamborlane W, Nally L. Commentary on CDC data showing an increased risk for pediatric diabetes with COVID‐19 infection. Journal Of Diabetes 2022, 14: 630-632. PMID: 36073304, PMCID: PMC9512767, DOI: 10.1111/1753-0407.13311.Peer-Reviewed Original ResearchConceptsCOVID-19 infectionIncidence of diabetesBody mass indexType of diabetesMortality Weekly ReportCommercial health insurancePrevention's MorbidityMass indexPediatric diabetesViral variantsSocial determinantsDisease controlDiabetesRecent CentersHealth insuranceCDC dataSignificant increaseInfectionWeekly reportsMorbidityIncidence
2021
Neonatal hyperinsulinism in transient and classical forms of tyrosinemia
Sethuram S, Sperling MA, Gujral J, Romero CJ. Neonatal hyperinsulinism in transient and classical forms of tyrosinemia. Orphanet Journal Of Rare Diseases 2021, 16: 190. PMID: 33910593, PMCID: PMC8082838, DOI: 10.1186/s13023-020-01642-y.Peer-Reviewed Original ResearchConceptsHyperinsulinemic hypoglycemiaMonths of lifeSpectrum of disordersRare metabolic disorderTransient tyrosinemiaDiazoxide therapyNeonatal periodPersistent hypoglycemiaInsulin secretionMaturational defectNeonatal hyperinsulinismRare caseMetabolic disordersHepatotoxic effectsPatientsBenign conditionsHereditary tyrosinemiaGenetic abnormalitiesBiochemical evaluationNovel presentationTyrosine metabolismEmbryonal originTyrosinemiaEnzyme defectFumarylacetoacetate hydrolaseExercise and Diabetes
Gujral J, Zgorski M, Tamborlane W. Exercise and Diabetes. Contemporary Endocrinology 2021, 151-154. DOI: 10.1007/978-3-030-64133-7_14.Peer-Reviewed Original Research
2020
Undervirilized male infant with in utero exposure to maternal use of high dose antifungal therapy
Gujral J, Costin G, Khurana D, Yau M, Wallach E, Romero CJ, Wilkes M, Sethuram S, Rapaport R. Undervirilized male infant with in utero exposure to maternal use of high dose antifungal therapy. International Journal Of Pediatric Endocrinology 2020, 2020: 16. PMID: 32944019, PMCID: PMC7488073, DOI: 10.1186/s13633-020-00087-1.Peer-Reviewed Original ResearchDays of lifeHuman chorionic gonadotropinMale infantCortisol responseHigh-dose antifungal therapyPerineo-scrotal hypospadiasSubnormal cortisol responseEndocrine disruptorsAntepartum useWeeks' gestationUtero exposureFirst trimesterMineralocorticoid deficiencyAdrenal corticosteroidsVaginal dischargeMale newbornsAntifungal therapyMaternal useMcg/Androgen receptorCommon pathologyAndrogen synthesisChorionic gonadotropinTesticular responseInfants
2019
Update: Pediatric Diabetes
Gujral J, Sethuram S, Rapaport R. Update: Pediatric Diabetes. Journal Of Diabetes 2019, 12: 262-264. PMID: 31837125, DOI: 10.1111/1753-0407.13012.Peer-Reviewed Original ResearchSUN-253 Effects of Growth Hormone Stimulation on the Immunologic Cellular Landscape in Pediatric Patients
Gujral J, Kidd B, Lee H, Golden E, Yau M, Dudley J, Rapaport R. SUN-253 Effects of Growth Hormone Stimulation on the Immunologic Cellular Landscape in Pediatric Patients. Journal Of The Endocrine Society 2019, 3: sun-253. PMCID: PMC6552874, DOI: 10.1210/js.2019-sun-253.Peer-Reviewed Original ResearchComplete blood countChronic GH administrationImmune systemGHS groupsPediatric patientsGH administrationGH statusAcute effectsTime pointsCyTOF analysisB cellsInterleukin-2 receptor levelsGrowth factor-1 axisTotal white blood cell countWhite blood cell countPeripheral blood mononuclear cellsGrowth hormone stimulation testPercent B cellsT cell percentageAbsolute lymphocyte countAbsolute neutrophil countPlasmacytoid dendritic cellsGH-deficient childrenPeak GH levelsAbsolute eosinophil countSUN-613 Papillary Thyroid Carcinoma in a Pediatric Patient with Beta Thalassemia
Choleva L, Rapaport R, Romero C, Yau M, Sethuram S, Gujral J, Wallach E, Wilkes M. SUN-613 Papillary Thyroid Carcinoma in a Pediatric Patient with Beta Thalassemia. Journal Of The Endocrine Society 2019, 3: sun-613. PMCID: PMC6553241, DOI: 10.1210/js.2019-sun-613.Peer-Reviewed Original ResearchPapillary thyroid carcinomaThyroid carcinomaBeta thalassemiaPediatric patientsRight lobeThyroid cancerChronic red blood cell transfusionsThyroid glandRed blood cell transfusionEnlarged right lobePalpable lymph nodesBlood cell transfusionFrequent blood transfusionsPapillary thyroid cancerMonth old femaleFine-needle aspirationCervical chainCell transfusionTotal thyroidectomyPostoperative courseBlood transfusionLymph nodesFerritin levelsHypoechoic massSecondary amenorrheaPrimary Cortisol Deficiency and Growth Hormone Deficiency in a Neonate With Hypoglycemia: Coincidence or Consequence?
Gujral J, Yau M, Yang AC, Kastury R, Romero CJ, Wallach E, Wilkes M, Costin G, Rapaport R. Primary Cortisol Deficiency and Growth Hormone Deficiency in a Neonate With Hypoglycemia: Coincidence or Consequence? Journal Of The Endocrine Society 2019, 3: 838-846. PMID: 30963141, PMCID: PMC6447946, DOI: 10.1210/js.2018-00386.Peer-Reviewed Original ResearchGrowth hormone deficiencyGH deficiencyGH secretionGH levelsSerum cortisolHormone deficiencyIGF-1Receptor defectElevated transaminase levelsRandom GH levelsTransient GH deficiencyEpisodes of hypoglycemiaMelanocortin 2 receptor geneHours of lifeFull-term boyUndetectable serum cortisolPg/mLMolecular genetic testingGlucocorticoid replacementHydrocortisone replacementTransaminase levelsCortisol deficiencyGH therapyNeonatal hypoglycemiaACTH levels