2023
Profiling neuronal methylome and hydroxymethylome of opioid use disorder in the human orbitofrontal cortex
Rompala G, Nagamatsu S, Martínez-Magaña J, Nuñez-Ríos D, Wang J, Girgenti M, Krystal J, Gelernter J, Hurd Y, Montalvo-Ortiz J. Profiling neuronal methylome and hydroxymethylome of opioid use disorder in the human orbitofrontal cortex. Nature Communications 2023, 14: 4544. PMID: 37507366, PMCID: PMC10382503, DOI: 10.1038/s41467-023-40285-y.Peer-Reviewed Original ResearchConceptsOpioid use disorderMulti-omics findingsGene expression patternsCo-methylation analysisGene expression profilesMulti-omics profilingGene networksDNA methylationNeuronal methylomesDNA hydroxymethylationMethylomic analysisExpression patternsExpression profilesEpigenetic disturbancesUse disordersPsychiatric traitsOrbitofrontal cortexOpioid-related drugsPostmortem orbitofrontal cortexEnvironmental factorsDrug interaction analysisOUD treatmentHuman orbitofrontal cortexOpioid signalingInteraction analysis
2014
Effects of corticotrophin-releasing factor receptor 1 antagonists on amyloid-β and behavior in Tg2576 mice
Dong H, Wang S, Zeng Z, Li F, Montalvo-Ortiz J, Tucker C, Akhtar S, Shi J, Meltzer HY, Rice KC, Csernansky JG. Effects of corticotrophin-releasing factor receptor 1 antagonists on amyloid-β and behavior in Tg2576 mice. Psychopharmacology 2014, 231: 4711-4722. PMID: 24862368, PMCID: PMC4233002, DOI: 10.1007/s00213-014-3629-8.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseAmyloid beta-Protein PrecursorAnimalsCorticotropin-Releasing HormoneCyclic AMPCyclic AMP-Dependent Protein KinasesDisease Models, AnimalHippocampusMaleMemoryMiceMice, TransgenicNeuronsPlaque, AmyloidPyrimidinesPyrrolesReceptors, Corticotropin-Releasing HormoneSignal TransductionConceptsAβ1-42 levelsCorticotrophin-releasing factorReceptor 1 antagonistPlaque depositionCRF1 antagonistsMouse modelDays of ageAlzheimer's diseaseMouse pupsIsolation stressCRF receptor 1 antagonistFactor receptor 1 antagonistAdministration of antalarminExogenous CRF administrationCultured primary hippocampal neuronsDaily intraperitoneal injectionsIncubation of neuronsCohort of micePlasma corticosterone levelsPrimary hippocampal neuronsMonths of ageCRF administrationAβ levelsIntraperitoneal injectionHippocampal neurons
2012
Corticotrophin Releasing Factor Accelerates Neuropathology and Cognitive Decline in a Mouse Model of Alzheimer's Disease
Dong H, Murphy KM, Meng L, Montalvo-Ortiz J, Zeng Z, Kolber BJ, Zhang S, Muglia LJ, Csernansky JG. Corticotrophin Releasing Factor Accelerates Neuropathology and Cognitive Decline in a Mouse Model of Alzheimer's Disease. Journal Of Alzheimer's Disease 2012, 28: 579-592. PMID: 22045495, PMCID: PMC3494090, DOI: 10.3233/jad-2011-111328.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAlzheimer DiseaseAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnalysis of VarianceAnimalsAnxietyBody WeightCalcium-Calmodulin-Dependent Protein Kinase Type 2Cognition DisordersConditioning, PsychologicalCorticosteroneCorticotropin-Releasing HormoneDark AdaptationDendritic SpinesDisease Models, AnimalDoxycyclineEnzyme-Linked Immunosorbent AssayExploratory BehaviorFearGene Expression RegulationHumansMiceMice, TransgenicNeuronsPlaque, AmyloidProsencephalonReceptors, Corticotropin-Releasing HormoneSilver StainingTubulinConceptsCorticotrophin-releasing factorTransgenic mouse modelTriple transgenic mouse modelTT miceMouse modelMonths of ageAlzheimer's diseaseExpression of CRFChronic stressHuman amyloid-β protein precursorNovel transgenic mouse modelDendritic spine densityAmyloid-β protein precursorAnxiety-like behaviorAβPP genePyramidal neuronsSpine densityAmyloid depositionAmyloid metabolismCRF expressionFrontal cortexBehavioral deficitsDendritic branchingCognitive declineMice