2016
The role of genes involved in stress, neural plasticity, and brain circuitry in depressive phenotypes: Convergent findings in a mouse model of neglect
Montalvo-Ortiz JL, Bordner KA, Carlyle BC, Gelernter J, Simen AA, Kaufman J. The role of genes involved in stress, neural plasticity, and brain circuitry in depressive phenotypes: Convergent findings in a mouse model of neglect. Behavioural Brain Research 2016, 315: 71-74. PMID: 27506655, PMCID: PMC5396458, DOI: 10.1016/j.bbr.2016.08.010.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDepressionDisease Models, AnimalGene Expression RegulationInhibitor of Differentiation ProteinsMaleMaternal DeprivationMaze LearningMiceMice, Inbred C57BLMice, Inbred DBAMicroarray AnalysisNerve Tissue ProteinsNeuronal PlasticityPrefrontal CortexReceptors, N-Methyl-D-AspartateRNA, MessengerStress, PsychologicalSwimmingConceptsTubulin Polymerization Promoting ProteinRole of genesGene expression dataEpigenetic changesGene expressionPhenotype dataExpression dataPrefrontal cortex tissueGenesSecondary analysisMedial prefrontal cortex (mPFC) tissueGlutamate NMDA receptorsAdult male miceId-3Early life stressPhenotypeSwimming testMale miceNMDA receptorsDepression riskMaternal separationMouse modelDepressive phenotypeBrain circuitryBehavioral differences
2008
Chronic underactivity of medial frontal cortical β2-containing nicotinic receptors increases clozapine-induced working memory impairment in female rats
Levin ED, Perkins A, Brotherton T, Qazi M, Berez C, Montalvo-Ortiz J, Davis K, Williams P, Christopher NC. Chronic underactivity of medial frontal cortical β2-containing nicotinic receptors increases clozapine-induced working memory impairment in female rats. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2008, 33: 296-302. PMID: 19146909, PMCID: PMC2684503, DOI: 10.1016/j.pnpbp.2008.12.003.Peer-Reviewed Original ResearchMeSH KeywordsAconitineAlpha7 Nicotinic Acetylcholine ReceptorAnimalsAntipsychotic AgentsCerebral CortexChronic DiseaseClozapineDihydro-beta-ErythroidineFemaleMaze LearningMemory DisordersMemory, Short-TermMicroinjectionsNicotinic AntagonistsPrefrontal CortexRatsRats, Sprague-DawleyReceptors, NicotinicConceptsMedial frontal cortexMemory impairmentNicotinic receptor activityFrontal cortexCognitive functionHippocampal infusionsRadial arm mazeNicotinic receptor involvementNicotinic receptor lossProcognitive treatmentsBrain systemsCognitive effectsMemory functionAntipsychotic drug interactionsMLA infusionsMemoryNicotinic receptorsCognitive impairmentBrain functionFemale ratsAntipsychotic drugsReceptor lossAntispychotic drugsCurrent studyAlzheimer's disease