2022
Dissecting the epigenomic differences between smoking and nicotine dependence in a veteran cohort
Nagamatsu S, Pietrzak R, Xu K, Krystal J, Gelernter J, Montalvo‐Ortiz J. Dissecting the epigenomic differences between smoking and nicotine dependence in a veteran cohort. Addiction Biology 2022, 28: e13259. PMID: 36577721, DOI: 10.1111/adb.13259.Peer-Reviewed Original ResearchConceptsSmoking statusNicotine dependenceVeteran cohortNon-current smokersSerious public health issueNovel treatment strategiesPublic health issueUS military veteransEpigenome-wide association studiesCurrent smokersTreatment strategiesFagerström TestNicotine addictionSmokingHealth issuesRole of epigeneticsMilitary veteransMethylationEPIC BeadChip arraySmokersContinuous variablesF2RL3 geneCohortBiomarkersBeadChip arrayPrevious findings
2017
Histone deacetylase inhibitors reverse age-related increases in side effects of haloperidol in mice
Montalvo-Ortiz JL, Fisher DW, Rodríguez G, Fang D, Csernansky JG, Dong H. Histone deacetylase inhibitors reverse age-related increases in side effects of haloperidol in mice. Psychopharmacology 2017, 234: 2385-2398. PMID: 28421257, PMCID: PMC5538925, DOI: 10.1007/s00213-017-4629-2.Peer-Reviewed Original ResearchConceptsMotor side effectsAged miceSide effectsValproic acidAge-related increaseHDAC inhibitorsAntipsychotic-induced side effectsDrd2 promoterAdjunct treatment strategyHistone deacetylase inhibitor valproic acidProtein levelsDopamine D2 receptorsInhibitor valproic acidHistone deacetylase inhibitorsDrug-dependent decreaseBackgroundOlder patientsMotor deficitsC57BL/6 miceAntagonist haloperidolTreatment strategiesYoung miceD2 receptorsPharmacodynamic mechanismsHaloperidolDeacetylase inhibitors