2023
Histone deacetylase inhibitors mitigate antipsychotic risperidone-induced motor side effects in aged mice and in a mouse model of Alzheimer’s disease
Rodriguez G, Fisher D, McClarty B, Montalvo-Ortiz J, Cui Q, Chan C, Dong H. Histone deacetylase inhibitors mitigate antipsychotic risperidone-induced motor side effects in aged mice and in a mouse model of Alzheimer’s disease. Frontiers In Psychiatry 2023, 13: 1020831. PMID: 36684015, PMCID: PMC9852991, DOI: 10.3389/fpsyt.2022.1020831.Peer-Reviewed Original ResearchMotor side effectsSevere neuropsychiatric symptomsAged miceSide effectsHDAC inhibitorsNeuropsychiatric symptomsDementia patientsHistone deacetylase inhibitor valproic acidAtypical antipsychotic risperidoneTypical antipsychotic haloperidolAntipsychotic drug targetsGreater side effectsInhibitor valproic acidHistone deacetylase inhibitorsAge-related sensitivityEpigenetic alterationsAtypical antipsychoticsD2R expressionAntipsychotic haloperidolLabel useAntipsychotic risperidoneAntipsychotic drugsMouse modelValproic acidClinical practice
2013
HDAC Inhibitors Restore the Capacity of Aged Mice to Respond to Haloperidol through Modulation of Histone Acetylation
Montalvo-Ortiz JL, Keegan J, Gallardo C, Gerst N, Tetsuka K, Tucker C, Matsumoto M, Fang D, Csernansky JG, Dong H. HDAC Inhibitors Restore the Capacity of Aged Mice to Respond to Haloperidol through Modulation of Histone Acetylation. Neuropsychopharmacology 2013, 39: 1469-1478. PMID: 24366052, PMCID: PMC3988551, DOI: 10.1038/npp.2013.346.Peer-Reviewed Original ResearchConceptsC-fos expressionAged miceValproic acidNucleus accumbensPrefrontal cortexYoung miceMS-275HDAC inhibitorsC-Fos expression patternHDAC inhibitor valproic acidAntipsychotic drug actionEffects of haloperidolAge-related decreaseInhibitor valproic acidHistone deacetylase inhibitorsElderly patientsHAL administrationHistone acetylationAntipsychotic drugsAvoidance responseBehavioral disturbancesElderly individualsClinical experienceHaloperidolEpigenetic changes
2008
Chronic underactivity of medial frontal cortical β2-containing nicotinic receptors increases clozapine-induced working memory impairment in female rats
Levin ED, Perkins A, Brotherton T, Qazi M, Berez C, Montalvo-Ortiz J, Davis K, Williams P, Christopher NC. Chronic underactivity of medial frontal cortical β2-containing nicotinic receptors increases clozapine-induced working memory impairment in female rats. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2008, 33: 296-302. PMID: 19146909, PMCID: PMC2684503, DOI: 10.1016/j.pnpbp.2008.12.003.Peer-Reviewed Original ResearchMeSH KeywordsAconitineAlpha7 Nicotinic Acetylcholine ReceptorAnimalsAntipsychotic AgentsCerebral CortexChronic DiseaseClozapineDihydro-beta-ErythroidineFemaleMaze LearningMemory DisordersMemory, Short-TermMicroinjectionsNicotinic AntagonistsPrefrontal CortexRatsRats, Sprague-DawleyReceptors, NicotinicConceptsMedial frontal cortexMemory impairmentNicotinic receptor activityFrontal cortexCognitive functionHippocampal infusionsRadial arm mazeNicotinic receptor involvementNicotinic receptor lossProcognitive treatmentsBrain systemsCognitive effectsMemory functionAntipsychotic drug interactionsMLA infusionsMemoryNicotinic receptorsCognitive impairmentBrain functionFemale ratsAntipsychotic drugsReceptor lossAntispychotic drugsCurrent studyAlzheimer's disease