2024
Support vector machine prediction of individual Autism Diagnostic Observation Schedule (ADOS) scores based on neural responses during live eye-to-eye contact
Zhang X, Noah J, Singh R, McPartland J, Hirsch J. Support vector machine prediction of individual Autism Diagnostic Observation Schedule (ADOS) scores based on neural responses during live eye-to-eye contact. Scientific Reports 2024, 14: 3232. PMID: 38332184, PMCID: PMC10853508, DOI: 10.1038/s41598-024-53942-z.Peer-Reviewed Original ResearchConceptsAutism Diagnostic Observation ScheduleAutism spectrum disorderAutism Diagnostic Observation Schedule scoresEye-to-eye contactSocial difficultiesNeural processesNeural responsesObservation ScheduleSymptoms of autism spectrum disorderBehavioural symptoms of autism spectrum disorderNeural activity patternsLive interaction paradigmTD groupSupport vector machineNeural mechanismsSymptom severityADOS scoresBehavioral symptomsSpectrum disorderASD diagnosisNeural dataActivity patternsAutismClassification methodMultivariate classification methods
2023
Investigating the Face Inversion Effect in Autism Across Behavioral and Neural Measures of Face Processing
Griffin J, Azu M, Cramer-Benjamin S, Franke C, Herman N, Iqbal R, Keifer C, Rosenthal L, McPartland J. Investigating the Face Inversion Effect in Autism Across Behavioral and Neural Measures of Face Processing. JAMA Psychiatry 2023, 80: 1026-1036. PMID: 37405787, PMCID: PMC10323765, DOI: 10.1001/jamapsychiatry.2023.2105.Peer-Reviewed Original ResearchFace processing systemFace inversion effectAutism spectrum disorderInversion effectFace processingNeurotypical sampleAutistic individualsEffect sizeHuman social cognitionPerformance differencesFace recognition taskPerformance-based measuresSocial cognitionNeural measuresNeurotypical individualsPsychological constructsNeural responsesSpectrum disorderElectrophysiological measuresRecognition taskBrain functioningBehavioral paradigmsRecognition demandsIdentity recognitionNeural systems
2022
Neural correlates of eye contact and social function in autism spectrum disorder
Hirsch J, Zhang X, Noah J, Dravida S, Naples A, Tiede M, Wolf J, McPartland J. Neural correlates of eye contact and social function in autism spectrum disorder. PLOS ONE 2022, 17: e0265798. PMID: 36350848, PMCID: PMC9645655, DOI: 10.1371/journal.pone.0265798.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderDorsal parietal regionsNeural correlatesEye contactLive eyesNeural responsesSpectrum disorderAutism Diagnostic Observation ScheduleUnderlying neural correlatesSocial Responsiveness ScaleGold standard measureCentral diagnostic criterionDiagnostic criteriaDiagnostic biomarkersSRS-2ADOS-2Responsiveness ScaleObservation ScheduleParietal regionsPupillometry dataNeural systemsEyesNatural interactionDisordersCorrelates
2020
Neurologic Characterization of Craniosynostosis: Can Direct Brain Recordings Predict Language Development?
Wu R, Nie J, Abraham P, Halligan T, Gabrick K, Peck CJ, Sawh-Martinez R, Steinbacher DM, Alperovich M, McPartland J, Persing JA. Neurologic Characterization of Craniosynostosis: Can Direct Brain Recordings Predict Language Development? Journal Of Craniofacial Surgery 2020, 32: 78-82. PMID: 32941205, DOI: 10.1097/scs.0000000000007004.Peer-Reviewed Original ResearchConceptsNeural responsesLanguage deficitsLanguage developmentERP assessmentMetopic patientsMismatch negativity waveLarger negative amplitudesLong-term cognitionLanguage achievementCognitive outcomesMMNBrain recordingsInfant developmentBayley ScalesNegative amplitudeBSID scoresEEG testingBSIDDeficitsElectroencephalogramNeurocognitionCognitionSpeechStimuliYears of age
2018
Normalization of Speech Processing After Whole-Vault Cranioplasty in Sagittal Synostosis
Chuang C, Rolison M, Yang JF, Brooks ED, Hashim PW, Travieso R, Terner J, Steinbacher DM, Landi N, Stavropoulos KKM, Mayes LC, Persing JA, McPartland JC. Normalization of Speech Processing After Whole-Vault Cranioplasty in Sagittal Synostosis. Journal Of Craniofacial Surgery 2018, 29: 1132-1136. PMID: 29621073, DOI: 10.1097/scs.0000000000004474.Peer-Reviewed Original ResearchConceptsEvent-related potentialsMMN amplitudeWhole-vault cranioplastyNeural responsesLanguage processingAtypical neural responsesEarly language processingLanguage-related abilitiesSpeech soundsNeurocognitive studiesDifference waveSpeech processingFrontal electrodesMMNNegative deflectionLarge negative deflectionNeurocognitive outcomesGroup interactionNonsyndromic sagittal craniosynostosisMeasures analysisInteraction trendsProcessingPhonemesPoststimulusElectrophysiological response during auditory gap detection: Biomarker for sensory and communication alterations in autism spectrum disorder?
Foss-Feig JH, Stavropoulos KKM, McPartland JC, Wallace MT, Stone WL, Key AP. Electrophysiological response during auditory gap detection: Biomarker for sensory and communication alterations in autism spectrum disorder? Developmental Neuropsychology 2018, 43: 109-122. PMID: 29436853, PMCID: PMC5972824, DOI: 10.1080/87565641.2017.1365869.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderAuditory gap detectionSpectrum disorderP2 event-related potential (ERP) componentsEvent-related potential componentGap detectionLanguage-related impairmentsAuditory processing deficitsElectrophysiological responsesProcessing deficitsAuditory stimuliNeural responsesAuditory inputASD biomarkersSilent gapsPotential componentsCommunication alterationsTemporal aspectsDeficitsAmplitude reductionDisordersStimuliSensory symptomsTreatment responseImpairment
2017
Event-related potentials index neural response to eye contact
Naples AJ, Wu J, Mayes LC, McPartland JC. Event-related potentials index neural response to eye contact. Biological Psychology 2017, 127: 18-24. PMID: 28396215, PMCID: PMC5593764, DOI: 10.1016/j.biopsycho.2017.04.006.Peer-Reviewed Original ResearchConceptsBrain responsesNeural markersGreater brain responseSocial cognitionERP componentsAutistic traitsIndividual differencesParticipants' gazeNeural responsesCo-registered EEGBrain activityEye contactNormative scoresMouth movementsMeaningful variabilitySocial functionReciprocal gazeSocial performanceGazeComponent differencesN170CognitionFaceP300Participants
2016
Autistic traits modulate conscious and nonconscious face perception
Stavropoulos KK, Viktorinova M, Naples A, Foss-Feig J, McPartland JC. Autistic traits modulate conscious and nonconscious face perception. Social Neuroscience 2016, 13: 40-51. PMID: 27750521, PMCID: PMC6194504, DOI: 10.1080/17470919.2016.1248788.Peer-Reviewed Original ResearchConceptsEvent-related potentialsAutism spectrum disorderAutistic traitsEmotional facesFace perceptionAutism QuotientAQ scoresShorter N170 latenciesBroader autism phenotypeHigher AQ scoresAutistic-like traitsEmotion perceptionN170 latencyNonconscious perceptionNeural underpinningsERP componentsAutism phenotypeConscious awarenessSocial perceptionSocial impairmentNeural responsesSpectrum disorderP300 amplitudeCore featuresSubclinical levels
2015
Common and distinct modulation of electrophysiological indices of feedback processing by autistic and psychopathic traits
Leno V, Naples A, Cox A, Rutherford H, McPartland JC. Common and distinct modulation of electrophysiological indices of feedback processing by autistic and psychopathic traits. Social Neuroscience 2015, 11: 455-466. PMID: 26471250, PMCID: PMC4939614, DOI: 10.1080/17470919.2015.1108223.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderPsychopathic traitsFeedback processingEvent-related potentialsCommon brain mechanismsNonsocial feedbackNeural correlatesAutistic traitsAntisocial domainsBrain mechanismsElectrophysiological indicesSocial feedbackTask performanceBehavioral tasksNeural responsesSpectrum disorderSocial dysfunctionSocial behaviorManipulation domainSimilar difficultiesCurrent studyProcessingDistinct modulationTraitsSpecific formDiminished social reward anticipation in the broad autism phenotype as revealed by event-related brain potentials
Cox A, Kohls G, Naples AJ, Mukerji CE, Coffman MC, Rutherford HJ, Mayes LC, McPartland JC. Diminished social reward anticipation in the broad autism phenotype as revealed by event-related brain potentials. Social Cognitive And Affective Neuroscience 2015, 10: 1357-1364. PMID: 25752905, PMCID: PMC4590535, DOI: 10.1093/scan/nsv024.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderAutistic traitsReward anticipationReward responsivenessEvent-related brain potentialsSocial reward responsivenessSocial reward anticipationSocial motivation theoryBroader autism phenotypeSocial communication problemsIncentive delay taskMotivated attentionReward sensitivityBrain potentialsAutism phenotypeReward processingTypical functioningP3 responseP3 componentNeural responsesMotivation theorySpectrum disorderSocial informationSocial interactionPrior findings
2014
Brain Electrophysiology Reveals Intact Processing of Speech Sounds in Deformational Plagiocephaly
Hashim PW, Travieso R, Persing JA, Coffman M, Mukerji C, Naples A, Tillman RM, Terner J, Landi N, Patel A, Steinbacher D, Mayes L, McPartland J. Brain Electrophysiology Reveals Intact Processing of Speech Sounds in Deformational Plagiocephaly. Plastic & Reconstructive Surgery 2014, 133: 835e-841e. PMID: 24867743, DOI: 10.1097/prs.0000000000000219.Peer-Reviewed Original ResearchConceptsEvent-related potentialsEvent-related potential componentSpeech soundsAuditory event-related potential (ERP) componentsLong-term cognitive functioningPotential componentsPrior researchIntact processingNeural correlatesCognitive functioningAuditory perceptionTypical childrenAuditory processingNeural responsesBrain recordingsLong-term impairmentSubsequent functioningBrain electrophysiologyNormative expectationsDevelopmental scaleCortical activityCortical responsesBrain functionDeformational plagiocephalyCranial disorders
2012
Neural Mechanisms of Improvements in Social Motivation After Pivotal Response Treatment: Two Case Studies
Voos AC, Pelphrey KA, Tirrell J, Bolling DZ, Wyk B, Kaiser MD, McPartland JC, Volkmar FR, Ventola P. Neural Mechanisms of Improvements in Social Motivation After Pivotal Response Treatment: Two Case Studies. Journal Of Autism And Developmental Disorders 2012, 43: 1-10. PMID: 23104615, PMCID: PMC4999079, DOI: 10.1007/s10803-012-1683-9.Peer-Reviewed Original ResearchConceptsPivotal Response TreatmentAutism spectrum disorderSocial stimuliResponse treatmentFunctional magnetic resonance imagingYoung childrenNeural correlatesSocial motivationSocial skillsSocial perceptionNeural mechanismsNeural responsesBehavioral measuresSpectrum disorderSocial communicationBehavioral treatmentEye trackingNeural systemsAdaptive behaviorBrain regionsBaseline measuresStriking gainsStimuliChildrenPositive effect
2011
Atypical neural specialization for social percepts in autism spectrum disorder
McPartland JC, Wu J, Bailey CA, Mayes LC, Schultz RT, Klin A. Atypical neural specialization for social percepts in autism spectrum disorder. Social Neuroscience 2011, 6: 436-451. PMID: 21777159, PMCID: PMC3204335, DOI: 10.1080/17470919.2011.586880.Peer-Reviewed Original ResearchConceptsNeural specializationNonsocial informationBehavioral performanceSocial informationSocial brain systemsSocial motivation hypothesisAtypical social developmentSpecificity of deficitsAberrant neural responsesEvent-related potentialsAutism spectrum disorderSocial perceptsFace processingCognitive abilitiesMotivation hypothesisBrain systemsElectrophysiological markersBrain responsesNeural responsesProcessing difficultiesSpectrum disorderStandardized measuresHuman faceAutismSpecific dysfunctionEnhanced neural responses to rule violation in children with autism: A comparison to social exclusion
Bolling DZ, Pitskel NB, Deen B, Crowley MJ, McPartland JC, Kaiser MD, Vander Wyk BC, Wu J, Mayes LC, Pelphrey KA. Enhanced neural responses to rule violation in children with autism: A comparison to social exclusion. Developmental Cognitive Neuroscience 2011, 1: 280-294. PMID: 21743819, PMCID: PMC3129780, DOI: 10.1016/j.dcn.2011.02.002.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderFunctional magnetic resonance imagingRight insulaVentral anterior cingulate cortexSocial exclusionAtypical neural networksRule violationsBall-tossing gameDorsal prefrontal cortexRepetitive behavior patternsAnterior cingulate cortexASD groupNeural correlatesBrain responsesSocial impairmentNeural responsesCharacteristic deficitsSpectrum disorderNeurobiological differencesPrefrontal cortexCingulate cortexFunctional connectivityComparable gamesInsulaGroup differences
2010
Neural responses to faces reflect social personality traits
Cheung CH, Rutherford HJ, Mayes LC, McPartland JC. Neural responses to faces reflect social personality traits. Social Neuroscience 2010, 5: 351-359. PMID: 20544557, PMCID: PMC3075017, DOI: 10.1080/17470911003597377.Peer-Reviewed Original ResearchConceptsNeural responsesFace-sensitive componentMarkers of expertiseSocial personality traitsFace perceptionN170 responseFace stimuliNeural correlatesInversion effectNormative sampleSocial informationVisual perceptsPersonality traitsHigh introversionPersonality characteristicsHigh extraversionBrain electrophysiologySocial attitudesSocial disabilityExtraversionIntroversionSocial interestStimuliFaceN170