2018
Incremental value of DNA analysis in pancreatic cysts stratified by clinical risk factors
Farrell J, Al-Haddad M, Jackson SA, Gonda T. Incremental value of DNA analysis in pancreatic cysts stratified by clinical risk factors. Gastrointestinal Endoscopy 2018, 89: 832-841.e2. PMID: 30447214, DOI: 10.1016/j.gie.2018.10.049.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaCyst FluidDNAEndoscopic Ultrasound-Guided Fine Needle AspirationFollow-Up StudiesGenes, Tumor SuppressorHumansKaplan-Meier EstimateLoss of HeterozygosityMutationPancreatic CystPancreatic NeoplasmsProportional Hazards ModelsProto-Oncogene Proteins p21(ras)Retrospective StudiesRisk AssessmentRisk FactorsSequence Analysis, DNASurvival AnalysisConceptsHigh-risk stigmataWorrisome featuresMalignancy riskPatient outcomesDNA abnormalitiesPredictive valueCyst fluid molecular analysisLong-term malignancy riskClinical risk factorsIncremental predictive valueCytologic malignancyClinical characteristicsFinal pathologyFree survivalSuch patientsPatient populationPancreatic cystsRisk factorsMalignant outcomeCyst fluidKras mutationsPatientsSurvival analysisAbnormalitiesTumor suppressor gene
2007
Risk of Malignancy in Resected Cystic Tumors of the Pancreas ≤3 cm in Size: Is it Safe to Observe Asymptomatic Patients? A Multi-institutional Report
Lee C, Scheiman J, Anderson M, Hines O, Reber H, Farrell J, Kochman M, Foley P, Drebin J, Oh Y, Ginsberg G, Ahmad N, Merchant N, Isbell J, Parikh A, Stokes J, Bauer T, Adams R, Simeone D. Risk of Malignancy in Resected Cystic Tumors of the Pancreas ≤3 cm in Size: Is it Safe to Observe Asymptomatic Patients? A Multi-institutional Report. Journal Of Gastrointestinal Surgery 2007, 12: 234-242. PMID: 18040749, DOI: 10.1007/s11605-007-0381-y.Peer-Reviewed Original ResearchConceptsCystic pancreatic tumorsPancreatic resectionFemale patientsCystic neoplasmsRadiographic featuresPancreatic tumorsRecent international consensus guidelinesHigh-volume pancreatic centersPancreatic resection databaseGroup of patientsInternational consensus guidelinesPresence of malignancyPrevalence of malignancyMagnetic resonance imagingAsymptomatic patientsMale patientsPancreatic centersConsensus guidelinesPathological dataMalignant pathologyEndoscopic ultrasoundHigh incidencePatientsMalignancyGreater incidence
2001
Detection and tumor staging of malignancy in cystic, intraductal, and solid tumors of the pancreas by EUS
Brandwein S, Farrell J, Centeno B, Brugge W. Detection and tumor staging of malignancy in cystic, intraductal, and solid tumors of the pancreas by EUS. Gastrointestinal Endoscopy 2001, 53: 722-727. PMID: 11375578, DOI: 10.1067/mge.2001.114783.Peer-Reviewed Original ResearchConceptsFine-needle aspirationIntraductal lesionsDirect fine needle aspirationEUS-guided fine-needle aspirationEvidence of malignancyResults of surgeryStaging of malignancyAccuracy of stagingAccuracy of EUSAbility of EUSSurgical explorationDuctal lesionsIntraductal tumorsPancreatic malignancyTumor stagingNeedle aspirationPancreatic massSolid lesionsEUS imagingMalignancySolid tumorsStaging malignanciesLesionsPancreasStaging