2024
Mechanism of Action of KL-50, a Candidate Imidazotetrazine for the Treatment of Drug-Resistant Brain Cancers
Huseman E, Lo A, Fedorova O, Elia J, Gueble S, Lin K, Sundaram R, Oh J, Liu J, Menges F, Rees M, Ronan M, Roth J, Batista V, Crawford J, Pyle A, Bindra R, Herzon S. Mechanism of Action of KL-50, a Candidate Imidazotetrazine for the Treatment of Drug-Resistant Brain Cancers. Journal Of The American Chemical Society 2024, 146: 18241-18252. PMID: 38815248, PMCID: PMC11409917, DOI: 10.1021/jacs.3c06483.Peer-Reviewed Original ResearchDNA repair capacityDifferential DNA repair capacityDNA interstrand cross-linksRepair capacityInterstrand cross-linksDisplacement of fluorideDNA repairCross-linkingAberrant DNA repairLesionsHealthy tissueBrain cancerRing openingHealthy cellsMGMTSelective chemotherapyGenotoxic agentsTumorChemical DNA modificationsCancerMultistep processRepair
2023
Non-viral vaccination through cationic guanidium polymer-pDNA polyplex mediated gene transfer.
Luther DC, Goswami R, Lee YW, Jeon T, Huang R, Elia JL, Nagaraj H, Bijlsma JJE, Piest M, Langereis MA, Rotello VM. Non-viral vaccination through cationic guanidium polymer-pDNA polyplex mediated gene transfer. Nanoscale 2023, 15: 10351-10359. PMID: 37288531, DOI: 10.1039/d2nr06428f.Peer-Reviewed Original ResearchEngineered Polymer-siRNA Polyplexes Provide Effective Treatment of Lung Inflammation.
Jeon T, Luther DC, Goswami R, Bell C, Nagaraj H, Cicek YA, Huang R, Mas-Rosario JA, Elia JL, Im J, Lee YW, Liu Y, Scaletti F, Farkas ME, Mager J, Rotello VM. Engineered Polymer-siRNA Polyplexes Provide Effective Treatment of Lung Inflammation. ACS Nano 2023, 17: 4315-4326. PMID: 36802503, DOI: 10.1021/acsnano.2c08690.Peer-Reviewed Original Research
2022
Cytosolic Protein Delivery Using Modular Biotin-Streptavidin Assembly of Nanocomposites.
Luther DC, Lee YW, Nagaraj H, Clark V, Jeon T, Goswami R, Gopalakrishnan S, Fedeli S, Jerome W, Elia JL, Rotello VM. Cytosolic Protein Delivery Using Modular Biotin-Streptavidin Assembly of Nanocomposites. ACS Nano 2022 PMID: 35435664, DOI: 10.1021/acsnano.1c06768.Peer-Reviewed Original Research
2021
Nanomaterial-based bioorthogonal nanozymes for biological applications.
Fedeli S, Im J, Gopalakrishnan S, Elia JL, Gupta A, Kim D, Rotello VM. Nanomaterial-based bioorthogonal nanozymes for biological applications. Chemical Society Reviews 2021, 50: 13467-13480. PMID: 34787131, PMCID: PMC8862209, DOI: 10.1039/d0cs00659a.Peer-Reviewed Original Research
2020
Direct Cytosolic Delivery of Proteins through Coengineering of Proteins and Polymeric Delivery Vehicles.
Lee YW, Luther DC, Goswami R, Jeon T, Clark V, Elia J, Gopalakrishnan S, Rotello VM. Direct Cytosolic Delivery of Proteins through Coengineering of Proteins and Polymeric Delivery Vehicles. Journal Of The American Chemical Society 2020, 142: 4349-4355. PMID: 32049533, PMCID: PMC7392052, DOI: 10.1021/jacs.9b12759.Peer-Reviewed Original Research