2014
Epidermal growth factor inhibits transforming growth factor-β-induced fibrogenic differentiation marker expression through ERK activation
Liu X, Hubchak SC, Browne JA, Schnaper HW. Epidermal growth factor inhibits transforming growth factor-β-induced fibrogenic differentiation marker expression through ERK activation. Cellular Signalling 2014, 26: 2276-2283. PMID: 24905473, PMCID: PMC4130781, DOI: 10.1016/j.cellsig.2014.05.018.Peer-Reviewed Original ResearchMeSH KeywordsActinsCell LineCollagen Type ICollagen Type I, alpha 1 ChainEnzyme ActivationEpidermal Growth FactorEpithelial-Mesenchymal TransitionErbB ReceptorsExtracellular Signal-Regulated MAP KinasesGene Expression RegulationHomeodomain ProteinsHumansMAP Kinase Kinase 1PhosphorylationPromoter Regions, GeneticRepressor ProteinsSmad2 ProteinSmad3 ProteinTransforming Growth Factor beta1
2008
TGF-β activates ERK5 in human renal epithelial cells
Browne JA, Pearson AL, Zahr RA, Niculescu-Duvaz I, Baines DL, Dockrell ME. TGF-β activates ERK5 in human renal epithelial cells. Biochemical And Biophysical Research Communications 2008, 373: 440-444. PMID: 18588859, DOI: 10.1016/j.bbrc.2008.06.058.Peer-Reviewed Original ResearchMeSH KeywordsCell Line, TumorEpithelial CellsHumansImidazolesKidneyMADS Domain ProteinsMEF2 Transcription FactorsMitogen-Activated Protein Kinase 7Myogenic Regulatory FactorsP38 Mitogen-Activated Protein KinasesProtein Kinase InhibitorsProtein Serine-Threonine KinasesPyridinesReceptor, Transforming Growth Factor-beta Type IReceptors, Transforming Growth Factor betaTransforming Growth Factor betaConceptsExtracellular signal-regulated kinase 5Epidermal growth factorMAP kinaseERK5 activationMyocyte enhancer factor 2Epithelial cell phenotypeP38 MAP kinase inhibitorRenal epithelial cellsMAP kinase inhibitorHuman renal epithelial cellsEmbryonic lethalityGrowth factorExtracellular signalsSB 202190Cell differentiationKinase 5Human PTECsPhospho-ERK5Cell phenotypeFactor 2KinaseEpithelial cellsKinase inhibitorsReceptor activityActivation