Serum amyloid A1 levels and amyloid deposition following a high-fat diet challenge in transgenic mice overexpressing hepatic serum amyloid A1
Jang W, Jeong J, Kim S, Kang M, Sung Y, Choi M, Park S, Kim M, Kim S, Ryoo Z. Serum amyloid A1 levels and amyloid deposition following a high-fat diet challenge in transgenic mice overexpressing hepatic serum amyloid A1. Applied Physiology Nutrition And Metabolism 2016, 41: 640-648. PMID: 27218680, DOI: 10.1139/apnm-2015-0369.Peer-Reviewed Original ResearchConceptsHigh-fat dietSAA1 levelsAmyloid depositionTg miceMetabolic disturbancesTransgenic miceHepatic serum amyloid A1Elevated levelsImpaired glucose toleranceLow-grade inflammationLocal cytokine expressionChronic inflammatory conditionsHigh-fat diet challengeSerum amyloid A1Acute phase response proteinsMajor precursor proteinCrohn's diseaseGlucose toleranceCytokine expressionInflammatory conditionsMetabolic parametersSerum amyloidMetabolic disordersAmyloid depositsDiet challenge